UPPSALA UNIVERSITY : Department of Cell and Molecular Biology
Structural Biology Groups
Uppsala universitet

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RiboCORE
Center for Photon Science
ICM
Structure and Function of Macromolecular Complexes

Professor Maria Selmer

Publications

2017

Newton MS*, Guo X*, Söderholm A*, Näsvall J, Lundström P, Andersson DI, Selmer M, Patrick WM (2017), “Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes”, PNAS published ahead of print April 17, 2017, doi:10.1073/pnas.1618552114
*These authors contributed equally
PubMed  paper 


2016

Ieong K-W., Uzun Ü., Selmer M. & Ehrenberg M. (2016), “Two proofreading steps amplify the accuracy of genetic code translation”, PNAS published ahead of print November 11, 2016, doi:10.1073/pnas.1610917113
PubMed  paper 


2015

Chen Y., Näsvall J., Wu S, Andersson D.I. & Selmer M. (2015), “Structure of AadA from Salmonella enterica: a monomeric aminoglycoside (3'')(9) adenyltransferase”, Acta Cryst. D 71:2267-77. doi: 10.1107/S1399004715016429. Epub 2015 Oct 31
PubMed  paper 

Söderholm A.*, Guo X.*, Newton M.S.*, Evans G.B:, Näsvall J., Patrick W.M. & Selmer M. (2015), “Two-step ligand binding in a (βα)8 barrel enzyme – substrate-bound structures shed new light on the catalytic cycle of HisA”, J. Biol. Chem. doi: 10.1074/jbc.M115.678086
*These authors contributed equally
PubMed  paper 


2014

Sun S., Selmer M., Andersson D.I. (2014), “Resistance to β-lactam antibiotics conferred by point mutations in penicillin-binding proteins PBP3, PBP4 and PBP6 in Salmonella enterica.”, PLoS One 9(5):e97202. doi: 10.1371/journal.pone.0097202. eCollection 2014.
PubMed  paper 


2013

Punekar A.S. & Selmer M. (2013), “Purification, crystallization and preliminary X-ray diffraction analysis of the 23S rRNA methyltransferase RlmJ from Escherichia coli”Acta Cryst. F 69, 1001-1003 First published online: August 19, 2013
PubMede  paper 

Punekar A.S., Liljeruhm J., Shepherd T.R., Forster A.C. & Selmer M. (2013), “Structural and functional insights into the molecular mechanism of rRNA m6A methyltransferase RlmJ”, Nucleic Acids Research. doi: 10.1093/nar/gkt719 First published online: August 13, 2013
Pubmed  paper 

Hultqvist G, Haq SR, Punekar AS, Chi CN, Engström A, Bach A, Strømgaard K, Selmer M, Gianni S, Jemth P. (2013), “Energetic Pathway Sampling in a Protein Interaction Domain.”, Structure doi:pii: S0969-2126(13)00192-5. 10.1016/j.str.2013.05.010. Epub ahead of print
PubMed  paper 


2012

Hultqvist G., Punekar A.S., Morrone A., Chi C.N., Engström Å., Selmer M., Gianni S. & Jemth P. (2012), “Tolerance of Protein Folding to a Circular Permutation in a PDZ Domain”, PLOS One. 7(11): 50055. doi:10.1371/journal.pone.0050055
PubMed  paper 

Punekar A.S., Shepherd T.R., Liljeruhm J., Forster A.C. & Selmer M. (2012), “Crystal structure of RlmM, the 2′O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA”, Nucleic Acids Research. 40(20):10507-20. doi: 10.1093/nar/gks727. Epub 2012 Aug 25.
PubMed  paper 

Koripella R.K., Chen Y., Peisker K., Koh C.S., Selmer M. & Sanyal S. (2012), “Mechanism of elongation factor-G mediated fusidic acid resistance and fitness compensation in Staphylococcus aureus”, J. Biol. Chem. 287(36):30257-67.
PubMed  pdf 

Selmer M., Gao Y.G., Weixlbaumer A. & Ramakrishnan V. (2012), “Ribosome engineering to promote new crystal forms”, Acta Cryst. D 68:578-583
PubMed  paper 

Guo, X., Peisker, K., Bäckbro, K., Chen, Y., Kiran Koripella, R., Mandava, C.S., Sanyal, S. & Selmer, M. (2012), “Structure and function of FusB: an elongation factor G-binding fusidic acid resistance protein active in ribosomal translocation and recycling”, Open Biol., 2: 120016
PubMed  paper 


2010

Chen, Y., Kiran Koripella, R., Sanyal, S. and Selmer, M. (2010), “Staphylococcus aureus elongation factor G – structure and analysis of a target for fusidic acid”, FEBS J., 277(18):3789-803
PubMed 

Haq S.R., Jürgens M.C., Chi C.N., Koh C.S., Elfström L., Selmer M., Gianni S., Jemth P. (2010), "The plastic energy landscape of protein folding: a triangular folding mechanism with an equilibrium intermediate for a small protein domain", J. Biol. Chem., 285(23):18051-9
PubMed  paper 


2009

Gao Y.G., Selmer M., Dunham C.M., Weixlbaumer A., Kelley A.C. and Ramakrishnan V. (2009), "The structure of the ribosome with elongation factor G trapped in the posttranslocational state", Science, 326(5953):694-9
PubMed 


2008

Selmer, M. and Liljas A. (2008), "Exit biology: battle for the nascent chain."Structure 16:498-500 (preview)
PubMed

2007

Dunham, C.M.*, Selmer, M.*, Phelps, S., Kelley, A.C., Suzuki, T., Joseph, S. and Ramakrishnan, V. (2007), “Structures of tRNAs with an expanded anticodon loop in the decoding center of the 30S Ribosomal Subunit”, RNA, 13(6):817-23, Epub April 6 2007
*These authors contributed equally
PubMed

Weixlbaumer A., Petry, S. #, Dunham, C.M. #, Selmer, M. #, Kelley, A.C. and Ramakrishnan V. (2007), “Crystal structure of the ribosome recycling factor bound to the ribosome”, Nature Struct. Mol. Biol., 14(8): 733-737, Epub July 29 2007; doi:10.1038/nsmb1282
#These authors contributed equally
PubMed 


2006

Selmer, M.*, Dunham, C.M.*, Murphy, F.V. IV, Weixlbaumer, A., Petry, S., Kelley, A.C., Weir, J.R. and Ramakrishnan, V. (2006), “Structure of the 70S ribosome complexed with mRNA and tRNA”, Science, Published online September 7 2006; 10.1126/science.1131127
*These authors contributed equally
PubMed

2005

Petry, S., Brodersen, D.E., Murphy, F.V. IV, Dunham, C.M., Selmer, M., Tarry, M.J., Kelley, A.C. and Ramakrishnan, V. (2005), “Crystal structures of the ribosome in complex with release factors RF1 and RF2 bound to a cognate stop codon”, Cell 123:1255–1266
PubMed

2004

Laurberg, M., Kristensen, O., Selmer, M., Su, X.-D. and Liljas, A. 2004. How do translation factors catalyze protein synthesis. In R. Holland Cheng & Lena Hammar, Eds "Conformational proteomics of Macromolecular Architecture" World Publishing Co. Pte. Ltd. Singapore. Chapter 14, pp307-329.

2003

Nikulin, A., Eliseikina, E., Tishchenko, S., Nevskaya, N., Davydova, N., Platonova, O., Piendl, W., Selmer, M., Liljas, A., Drygin, D., Zimmermann, R., Garber, M. and Nikonov, S. (2003), “Structure of the L1 protuberance in the ribosome”, Nature Struct. Biol. 10(2):104-108
PubMed

2002

Selmer, M., Wilting, R., Holmlund, D. and Su, X-D. (2002), “Preparation of a crystallizable mRNA binding domain of Moorella thermoacetica elongation factor SelB”, Acta Cryst D 58:1871-1873
PubMed

Selmer, M. and Su, X-D. (2002), “Crystal structure of an mRNA binding fragment of Moorella thermoacetica elongation factor SelB”, EMBO J. 41:4145-4153
PubMed

Hirokawa, G., Kiel, M.C., Muto, A., Selmer, M., Liljas, A., Igarashi, K. and Kaji, A. (2002), “Release of tRNA and mRNA from the post-termination complex by Elongation Factor G and Ribosome Recycling Factor, a functional tRNA mimic, EMBO J. 21:2272-2281
PubMed

Selmer, M. (2002) “Protein-RNA interplay in translation. Structural studies of RRF, SelB and L1.” doctoral thesis, Lund University
Summary

Kristensen, O., Laurberg, M., Liljas, A. and Selmer, M. (2002), ”Is tRNA mimicry or tRNA binding mandatory for translation factors?” Curr. Prot. Pept. Sci. 3:133-141 (review)
PubMed


2001

Fedorov, R., Meshcheryakov,V., Gongadze, G., Fomenkova, N., Nevskaya, N., Selmer, M., Laurberg, M., Kristensen, O., Al Karadaghi, S., Liljas, A., Garber, M. and Nikonov, S. (2001) “Structure of ribosomal protein TL5 complexed with RNA provides new insights into the CTC family of stress proteins” Acta Cryst. D 57:968-976
PubMed

1999

Selmer, M., Al-Karadaghi, S., Hirokawa, G., Kaji, A. and Liljas, A. (1999) “Crystallization and preliminary X-ray analysis of Thermatoga maritima Ribosome Recycling factor” Acta Cryst. D 55:2049-2050
PubMed

Selmer, M., Al-Karadaghi, S., Hirokawa, G., Kaji, A. and Liljas, A. (1999) “Crystal structure of Thermotoga maritima Ribosome recycling factor: a tRNA mimic” Science 286:2349-2352
PubMed