SHERRY LYNN MOWBRAY

Address: Swedish University of Agricultural Sciences

Department of Molecular Biology

Box 590, Biomedical Center

S-751 24 Uppsala, Sweden

Telephone: 46-18-471 49 90 e-mail: MOWBRAY@xray.bmc.uu.se

Born: December 18, 1954 (pn: 541218-1124)

Nationality: U. S. citizen

Education:

B.Sc., Honours (Biochemistry), Queen's University at Kingston, Ontario, Canada, 1976

Ph.D., Chemistry (Biophysics), Massachusetts Institute of Technology, Cambridge, MA, 1983

Professional Experience:

Research assistant (1976-1978): Structural studies of a polysaccharide from Mycobacterium smegmatis with Dr. D. J. Walton of the Department of Biochemistry, Queen's University, Kingston, Ontario, Canada

- Experience including organic synthesis; protein and polysaccharide purification; gas-liquid chromatography; NMR.

Graduate student (1979-1983): X-ray crystallographic studies of periplasmic binding proteins involved in chemotaxis with Dr. G. A. Petsko of the Department of Massachusetts Institute of Technology, Cambridge, MA.

- Experience including bacterial fermentation; protein purification, assay and analysis; protein crystallization; X-ray structure solution by multiple isomorphous replacement and molecular replacement.

Post-doctoral fellow (1983-1987): Biochemical and crystallographic studies of the membrane-bound aspartate receptor involved in bacterial chemotaxis with Dr. D. E. Koshland, Jr. of Department of Biochemistry and Dr. S.-H. Kim of the Department of Chemistry, University of California, Berkeley, CA.

Experience including membrane protein purification and crystallization; amino acid, N-terminal and peptide analysis using HPLC; bacterial behavioral studies; cloning; DNA sequencing; site-directed mutagenesis; fluorescence and CD spectroscopy.

Assistant Professor (1987-1990): Biochemical and crystallographic studies of receptors and membrane proteins. Departments of Biochemistry and Pharmacology, Howard Hughes Medical Institute, The University of Texas Southwestern Medical Center, Dallas, TX

- Head of a research group of five people engaged in protein purification, crystallization, structure solution and refinement, cloning and site-directed mutagenesis. Also responsible for operation of the Hughes Institute's fermentation facility. Teach sections in various courses (Medical Biochemistry, Graduate Biochemistry, Advanced Protein Chemistry, Advanced Cell and Molecular Biology).

Researcher/Docent (1990-1999): Biochemical and crystallographic studies of proteins. Department of Molecular Biology, Swedish University of Agricultural Sciences, Biomedical Center, Uppsala

- Head of research group, graduate/undergraduate teaching

- docent, 1992

University Lecturer (10 May, 1999-8 Sept, 1999):

biochemistry, specialization in protein structure/function

Professor (9 September, 1999-present):

professor of biochemistry, Swedish University of Agricultural Sciences. Course organizer for 10 p course in Protein Technology, as well as leading research group.

Awards and Fellowships:

National Merit Scholarship Honorary Award, 1972

Bausch and Lomb Honorary Science Award, 1972

Rhode Island State Scholarship, 1972

Research Award from Sigma Xi, 1981

Genentech Fellowship, 1982-83

Jane Coffin Childs Memorial Fellowship, 1983-1986

American Cancer Society Senior Fellowship 1986-1987

Other activities

editorial board of the journal Receptor (appointed 1989)

member of the steering committee for the Biotechnology program, Swedish University of Agricultural Sciences, 1999-2004

referee for various scientific journals, including Journal of Molecular Biology, Journal of Biological Chemistry, EMBO Journal, Journal of the American Chemical Society, Acta Crystallographica, Proceeding of the National Academy of Sciences (USA), Trends in Biochemical Sciences, FEBS Letters, Protein Science, and Structure, etc.

outside referee for various British and US funding agencies

member of the Biotechnology review section of the Swedish Research Council, 2001-2003

member of the Chalmers Biotechnology graduate program referee board

member of the Advisory Council for the Swedish Foundation for Strategic Research

member of the Faculty of 1000, Plant biochemistry & physiology sections, 2004-present

Invited talks at international meetings, representative sample:

Gordon Conference on Bacterial Cell Surfaces, Keene, New Hampshire, July, 1985.

Cold Spring Harbor Symposium on Evolution on Biological Molecules, Cold Spring Harbor, New York, June, 1987.

Conference on Bacterial Locomotion and Sensory Transduction, Austin, Texas, January, 1991.

The Maltose System: Molecular Genetics and Cell Biology, Konstanz, Germany, September, 1991.

Gordon Conference on Bacterial Cell Surfaces, July 1992.

Chairperson of session, Gordon Conference on Diffraction Methods in Molecular Biology, June 1992.

Bacterial Locomotion and Signal Transduction, Austin, TX, 12-16 January, 1995, speaker and chair of session.

Molecular Recognition and Signaling, 19-21 December, 1995, Bath, England

Structural Biology in Sweden, 29 November, 1996, Uppsala, Sweden

Bacterial Locomotion and Signal Transduction, 9-13 January, 1997, Mexico (2 hour workshop on protein crystallization, presented with Mats Sandgren)

Symposium on Structure and Function of Cell Surface Proteins, University of Konstanz, Germany, 9-10 May, 1997 "Structure of periplasmic binding proteins as high affinity sites of bacterial ABC transporters"

Bacterial Locomotion and Signal Transduction, 16-20 January, 1999, Mexico (also 2 hour workshop on protein crystallization)

Como Crystallographic Workshop, May, 1999 "How reproducible are structures?"

SBNet meeting at Tällberg, Sweden, June, 1999, "Errors and reproducibility in protein x-ray structure determination"

International Union of Crystallography Conference, Glascow, 8 August, 1999 "Errors and reproducibility in protein x-ray structure determination"

Chairperson of “Omics” session, SBNet meeting at Tällberg, Sweden, June, 2000.

Talk at Gordon Conference on Diffraction Methods in Molecular Biology, "Everybody makes mistakes: some thoughts on why, and what to do about it.” July 4, 2000

Plenary lecture, Bacterial Neural Networks, Obernai, France, June 2002 "Transmembrane signaling in chemotaxis"

Lecture, AsCA'03/Crystal-23 meeting, Broome, Australia, August 2003 " Enzymes of ribose metabolism: structure and mechanism”

December, 2003 'Structure elucidation of an enzyme and its active site' Mr. Ubhaysekera was invited by the Sri Lanka Association for the Advancement of Science (SLAAS), to give a talk in the Auditorium of the Association in Colombo, Sri Lanka.

Selected talks outside SLU (beginning Dec. 1994)

Stockholm University, 1 December, 1994 - Receptors in bacterial chemotaxis.

UTSW, Dallas, Texas 23 January, 1995 - The role of periplasmic binding proteins in chemotaxis and transport.

Karolinska Institute, Huddinge, 22 February, 1996 - Conformational changes determine the role of periplasmic binding proteins in chemotaxis and transport.

Umeå University, 12 October, 1996. Conformational changes determine the role of periplasmic binding proteins in chemotaxis and transport.

Karolinska Institute, 20 January, 1997 Conformational changes of periplasmic binding proteins in chemotaxis and transport.

University of Mainz, 4 August, 2000. Structure and function of epoxide hydrolases.

University of California, Berkeley, 21 April, 2004, Structure and function of proteins of ribose metabolism.

Stanford University, 23 April, 2004, Structure and function of proteins of ribose metabolism.

Instruction in graduate training courses outside SLU

EMBO Practical Course on Protein Crystallography, Uppsala, 27 May - 7 June, 1991

FEBS/EACMB Advanced Course “Techniques in Protein Crystallography”, Aarhus, 9-18 June, 1992

Protein Engineering Course , Uppsala University, 11-14 January, 1993

Protein Engineering Course, University of Göteborg, 20 January, 1994

Practical Protein Crystallization course, Uppsala, 21 September, 1999

Pedagogical courses:

SLU departmental, 1997

Forskarutbildningskonferensen 30 September, 1999

Forskarutbildningskonferensen 26 October, 2000

Handledningskursen, 16-17 November, 2000

Forskarutbildningskonferensen 31 October, 2001

Forskarutbildningskonferensen, October, 2002

PhD thesis committees:

Jamie McKnight, University of Texas, Southwestern, 1990. Chairman.

Laura Lark, University of Texas Southwestern, 1991.

Anders Holmgren, Swedish Agricultural University, 1992. Chairman.

Thomas Taylor, Swedish Agricultural University, 1996, reserve.

Arnold Andersson, Swedish Agricultural University, 1996.

Kristina Bäckbro, Uppsala University, 31 May 1997

Christer Wikner, Karolinska Institutet, 30 May 1997

Tomas Hansson, Uppsala University, 16 May 1998. Chairman.

Christophe Thibideau, Uppsala University, 8 February, 1999. Chairman.

Louse Krafft, Karolinska Institute, MSc., 2001

Jeff Abramson, Uppsala University, PhD. April, 2001

Devapriya Choudhury, Swedish University of Agricultural Sciences, PhD, May, 2001

Louse Krafft, Karolinska Institute, PhD., Dec 2001

Jimmy Lindberg, examiner for half-time evaluation, 8 February, 2002

Priit Väjamäe, Uppsala University, PhD, 20 December, 2002

Daniel Nöteberg, Uppsala University, PhD, 7 March, 2003

Isabella Feierberg, Uppsala University, PhD, April, 2003

Alona Pavlova, Swedish University of Agricultural Sciences, PhD, 12 June, 2003

Lovisa Afzelius, Uppsala University, PhD, December, 2003

Anton Poliakov, Uppsala University, PhD, April, 2004

Gunilla Carlsson, Uppsala University, PhD, 22 September, 2004

Lars Hildén, Swedish University of Agricultural Sciences, PhD, 7 October, 2004, Chairman

Emanuel Smeds, Uppsala University, PhD, 21 January, 2005

Dan Backman, Uppsala University, PhD, 3 June, 2005

Azmiri Sultana, Karolinska Institut, half-time control, 13 Jun, 2005

Linda Arnfors, Karolinska Institut, licenciat, 13 October, 2005

PhD thesis examiner

examiner, JP Morth, Aarhus Universitry, Aarhus Denmark, 8 February, 2005

Master’s thesis examiner

examiner, Helena Häggblad, Protein homology modeling in ICM-assessment of model quality and reliability, Molecular Biotechnology program, Uppsala University School of Engineering, supervisor Maria Flocco (Pharnacia), 20 June, 2000

examiner, Linda Johansson, Adding a tag to thioredoxin bearing selenomethionine, SLU Biotechnology program, supervisor Elias Arner, Karolinska Institutet ( Department of Medical Biochemistry and Biophysics, Karolinska Institutet), June 2001

examiner, Annette Roos, Structure-function studies of proteins from Mycobacterium tuberculosis, supervisor Ted Baker, University of Aukland, New Zeeland, spring 2002

examiner, Maria Bergsland, Assay of viral counts, supervisor Christine Dartsch, Astrazeneca, December, 2002

examiner, Karin Andersson, Wild-type presenilin-1 sensitises cells to apoptotic stimuli, supervisor Maria Ankarcrona, PhD. Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, Huddinge. 13 June, 2003

examiner, Kerstin Ahlgren, Site directed mutagenesis of L-CPT 1 and the effect on beta-oxidation in transient transfected liver cells, supervisors Björn Kull & Magnus Jansson, Department of Biology, Biovitrum, June, 2004.

examiner, Anna Wahren, Characterization of SIK2 kinase effects on insulin receptor signaling and glucose metabolism, supervisor Eva Rupp Thuresson, Dep. of Biology, Biovitrum, 16 March, 2005.

examiner,Maria Ekman, Unravelling post mortem changes in cattle muscle using proteomics, supervisor, Matforsk, Norway.

examiner, Johan Winquist, Characteristics of PrrA-C binding to its DNA targets in the photosynthetic bacterium Rhodobacter sphaeroides. Supervisor Dr M.K. Phillips-Jones, University of Leeds, UK.

Posters since 1990 and conferences attended by group members (not very complete):

The 1.6 Å refined X-ray structures of the periplasmic ribose and glucose/galactose receptors involved in transport and chemotaxis in E. coli. S.L. Mowbray. American Crystallographic Association, Toledo, 21-26 July, 1991.

Mutations of the E. coli aspartate/maltose receptor which affect aspartate binding. M. Junerup, N. Vangipurnam, Q. Vu, V. Feiz, P. Dunten and S. Mowbray. The Maltose System: Molecular Genetics and Cell Biology, 1-6 Sept. 1991, Konstanz, Germany.

Mutants of the ribose receptor that affect chemotaxis and transport. J. Björkman, A. Binnie, L.B. Cole and S.L. Mowbray. Understanding Protein Folding, Novum Research Center, Stockholm, 24-28 August, 1992.

Arginine NE and its interactions with the aromatic rings of phe, tyr and trp in proteins. M.M. Flocco and S.L. Mowbray. Understanding Protein Folding, Novum Research Center, Stockholm, 24-28 August, 1992.

In vivo and in vitro studies of mutant Tar receptor in Escherichia coli. M. Junerup, N. Vangipurnam, Q.Vu, V. Feiz, P. Dunten and S.L. Mowbray. Understanding Protein Folding, Novum Research Center, Stockholm, 24-28 August, 1992.

Arginine NE and its interactions with the aromatic rings of phe, tyr and trp in proteins. M.M. Flocco and S.L. Mowbray. American Crystallographic Association, Pittsburgh, 9-14 August, 1992.

Crystallization of the periplasmic dipeptide-binding protein from E. coli. P. Dunten and S.L. Mowbray. Bacterial Locomotion and Signal Transduction, Austin, 14-18 January, 1993.

In vivo and in vitro studies of mutant Tar receptor in Escherichia coli. M. Junerup, N. Vangipurnam, Q.Vu, V. Feiz, P. Dunten and S.L. Mowbray. Bacterial Locomotion and Signal Transduction, Austin, 14-18 January, 1993.

Expression and purification of the cytoplasmic domain of the Tar receptor from S. typhimurium. B.H. Shilton, P.W. Dunten and S.L. Mowbray. Bacterial Locomotion and Signal Transduction, Austin, 14-18 January, 1993.

Three dimensional structure of the close unliganded periplasmic glucose/galactose receptor from Salmonella typhimurium M. Flocco and S. Mowbray, European Workshop on Crystallography of Biological Macromolecules, Como, Italy, 24-28 May, 1993.

M. Flocco, Understanding Signal Transduction, Novum Research Park, Stockholm, 17-20 June, 1993, participant.

P. Dunten, CCP4 Study Weekend on Molecular Replacement, Daresbury, England, 6-8 Jan, 1994, participant.

P. Dunten, York Course on Protein Structure Refinement, York, England, 9-12 Jan, 1994, paricipant.

B. Shilton, EMBO Data Collection Course, Cambridge, England, 27 Feb - 5 Mar, 1994, participant.

Three dimensional structure of the close unliganded periplasmic glucose/galactose receptor from Salmonella typhimurium M. Flocco and S. Mowbray, Gordon Research Conference on Diffraction Methods in Molecular Biology, Andover, NH, 19-24 June, 1994.

Structure of the periplasmic receptor for dipeptides in E. coli. P. Dunten, Gordon Research Conference on Bacterial Cell Surfaces, Keene, NH, 10-15 July, 1994.

Three dimensional structure of the close unliganded periplasmic glucose/galactose receptor from Salmonella typhimurium M. Flocco and S. Mowbray Bacterial Locomotion and Signal Transduction, Austin, 12-16 January, 1995.

Characterization and crystallization of the cytoplasmic portion of the Tar chemoreceptor from S. typhimurium. Mats O.J. Sandgren, Brian H. Shilton, Pete W. Dunten and Sherry L. Mowbray Bacterial Locomotion and Signal Transduction, Austin, 12-16 January, 1995.

Crystallization of the cytoplasmic portion of the Tar chemoreceptor from S. typhimurium. Mats Sandgren, Brian H. Shilton and Sherry L. Mowbray European Crystallographic Meeting, Lund, Sweden, 6-11 August, 1995.

Ribokinase: preliminary X-ray crystallography studies. Jill A. Sigrell, Alexander D. Cameron and Sherry L. Mowbray European Crystallographic Meeting, Lund, Sweden, 6-11 August, 1995.

Probing protein-protein interactions: Structural studies on E. coli ribose-binding protein mutants that affect chemotaxis and transport. Sherry L. Mowbray, A. Joakim Björkman, R. Alan Binnie, Huide Zhang and Mark A. Hermodson. European Crystallographic Meeting, Lund, Sweden, 6-11 August, 1995.

Crystal structures and solution conformations of a dominant-negative mutant of Escherichia coli maltose-binding protein. Brian H. Shilton, Howard A. Shuman, and Sherry L. Mowbray International Union of Crystallography, Seattle, 10-17 August, 1996.

The use of SeMet as a derivative in the structure determination of Ribokinase from E. coli." Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L., presented at the summer school "Understanding Protein Motions", September 1996, Stockholm, Sweden.

Course on Data Collection, Cambridge, 11/96 Jill Sigrell

Course on Maximum Likelihood, Barnali Chauduri, around 10/96

Conformational changes of periplasmic binding proteins in chemotaxis and transport. Joakim Björkman, Maria Flocco, Brian Shilton, Pete Dunten and Sherry Mowbray. BLAST meeting, Mexico, 9-13 January, 1997.

Crystallisation of the cytoplasmic portion of tar chemoreceptor from S. typhimurium Mats O.J. Sandgren, Brian H. Shilton, Pete W. Dunten, Sherry L. MowbrayBLAST meeting, Mexico, 9-13 January, 1997.

Conformational changes of ribose-binding protein in chemotaxis and transport. Joakim Björkman and Sherry Mowbray. SBNet meeting, Tällberg, Sweden, 6-9 June, 1997.

Expression of the Platelet-derived Growth Factor alpha-Receptor. Mary-Rose Hoja, K. Miyazawa, Arne Östman, C. Heldin, T. A. Jones and S. L. Mowbray, SBNet meeting, Tällberg, Sweden, 6-9 June, 1997.

Crystallisation of the cytoplasmic portion of tar chemoreceptor from S. typhimurium. Mats O.J. Sandgren, Brian H. Shilton, Pete W. Dunten, Sherry L. MowbraySBNet meeting, Tällberg, Sweden, 6-9 June, 1997.

Structural studies on D-allose binding protein from Escherichia coli. B. Chauduri, Junsang Ko, C. Park, T. A. Jones and Sherry L. MowbraySBNet meeting, Tällberg, Sweden, 6-9 June, 1997.

A dedicated expression lab in Uppsala. Eva Davey, Petra Franzén and Sherry L. Mowbray. SBNet meeting, Tällberg, Sweden, 6-9 June, 1997.

E. coli ribokinase - a new fold gives new ideas about kinase function. Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L., presented at European Crystallography Meeting17, August 1997, Lisbon, Portugal.

A binding protein-dependent ABC transport system for maltose in Alicyclobacillus acidocaldarius. Anja Herrmann, Mats Sandgren, Sherry Mowbray, Erwin Schneider.

Ribose makes ribokinase fly. Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L. presented at the Structural Biology Network (SBNet) Second Annual Conference in Tällberg, Sweden, May 1998.

Mats Sandgren, Anya Hermann, Sherry Mowbray, and Erwin Schneider, meeting title?, March, 1998.

Cellulose Binding in Family 7 Cellulases: P. Chrysosporium Cbh 58 And T. reesei CBH 1 And EG 1. Jerry Stahlberg, Ines Munoz and Sherry L. Mowbray. 7th International Conference on Biotechnology in thePulp and Paper Industry" Vancouver, June 16-19, 1998

Cellulose Binding in Family 7 Cellulases: P. Chrysosporium Cbh 58 And T. reesei CBH 1 And EG 1. I.G. Munoz, J. Ståhlberg, C. Divne, G. Kleywegt, H. Henriksson, G. Johansson, S.L. Mowbray and T.A. Jones. Conference on “The role of cell wall degrading enzymes of Trychoderma harzianum in bioocontrol”. 31 July- 3 August, 1998. Tynset, Norway.

A progress report on the conformational changes and mechanism of E. coli ribokinase. EvaLena Andersson and Sherry Mowbray, Meeting of Structural Biology Network (SBNet) of the SwedishFoundation for Strategic Research, 11-14 June, 1999

Purification and crystallisation of PDGF alfa & beta and DEP-1 protein tyrosine phosphatase Ulrika Magnusson, Camilla Persson, Arne Östman, Alwyn Jones and Sherry Mowbray, Meeting of Structural Biology Network (SBNet) of the Swedish Foundation for Strategic Research, 11-14 June, 1999

X-ray structure of CBH 58 from Phanerochaete chrysosporium" Inés G. Muñoz, Jerry Ståhlberg, Gunnar Johansson, Göran Pettersson, Sherry L. Mowbray and T. Alwyn Jones, Meeting of Structural Biology Network (SBNet) of the Swedish Foundation for Strategic Research, 11-14 June, 1999

Structural studies of carbohydrate-degrading enzymes. Sherry Mowbray, Ines Munoz, Jerry Stahlberg. GLIBS network meeting, September, 1999

New insights into the enzymatic mechanism of epoxide detoxification by epoxide hydrolases revealed by three-dimensional structure analysis Michael Arand, Jinyu Zou, Martin Hallberg, Terese Bergfors, Heike Dürk, Heike Hemmer, Franz Oesch, Sherry L. Mowbray and T. Alwyn Jones. German Association of Pharmacologists and Toxicologists, spring 2000.

The structure of allose-binding protein from E. coli. Magnusson U, Jones TA, Mowbray SL., Fourth Annual Conference of the Swedish Structural Biology Network, Tällberg, Sweden, 9 - 12 June, 2000

New insights into the function of E. coli ribokinase. C. Evalena Andersson, Sherry L Mowbray and T. Alwyn Jones, Fourth Annual Conference of the Swedish Structural Biology Network, Tällberg, Sweden, 9 - 12 June, 2000

Structural studies of two carbohydrate-degrading enzymes. Wimal Ubhayasekera,Sherry Mowbray, Ines Munoz, Jerry Stahlberg, Alwyn Jones, Gunnar Johansson, Istvan Szabo, Sabah Mahdi, Fourth Annual Conference of the Swedish Structural Biology Network, Tällberg, Sweden, 9 - 12 June, 2000

Structural studies of carbohydrate-degrading enzymes. Wimal Ubhayasekera, Sherry Mowbray, Ines Munoz, Jerry Stahlberg. GLIBS network meeting, 14-17 October, 2000.

Arand, M., Zou, J., Hallberg, M., Bergfors, T., Dürk, H., Hemmer, H., Oesch, F., Mowbray, S. L. & Jones, T. A. (2000). 41st Spring Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, Mainz.

Arand, M., Zou, J., Hallberg, M., Bergfors, T., Dürk, H., Hemmer, H., Oesch, F., Mowbray, S. L. & Jones, T. A. (2000). 13th International Symposium on Microsomes and Drug Oxidation, Stresa, Italy.

Primary sequence determinants responsible for PDGF R site-selective dephosphorylation by the rPTP DEP-1. Camilla Persson¹, Marina Kovalenko¹, Ulla Engström¹, Sherry Mowbray² and Arne Östman, presented at Tyrosine phosphorylation and cell signaling', Cold Spring Harbour, NY, May 16-20 2001

Structural studies of Allose-binding Protein, Ulrika Magnusson, T. Alwyn Jones and Sherry L. Mowbray, presented at the Fifth international school on Crystallography, Como, Italy, May13-17, 2001

3D-Structures of Phanerochaete chrysosporium cellobiohydrolases (Pc_Cel7s)

Wimal Ubhayasekera, Inés G. Muñoz, Gunnar Johansson, T. Alwyn Jones, Jerry Ståhlberg, Sherry L. Mowbray, 6^th International School on Crystallography of Biological Macromolecules, Villa Erba, Como, Italy, 13-17 May 2001

3D-Structures of Phanerochaete chrysosporium cellobiohydrolases (Pc_Cel7s)

Wimal Ubhayasekera, Inés G. Muñoz, Gunnar Johansson, T.Alwyn Jones, Jerry Ståhlberg, Sherry L. Mowbray, 4^th Carbohydrate Bioengineering Meeting, Royal Institute of Technology, Stockholm, Sweden, 10^th – 13^th June 2001.

3D-Structures of family 7 glycoside hydrolases from Phanerochaete chrysosporium

Wimal Ubhayasekera, Inés G. Muñoz, Gunnar Johansson, T.Alwyn Jones, Jerry Ståhlberg, Sherry L. Mowbray, Gordon Research Conference on ‘Cellulases and Cellulosomes’, Proctor Academy, Andover, New Hampshire, USA, 29 July – 02 Aug 2001.

3D-Structures of family 7 glycoside hydrolases from Phanerochaete chrysosporium. Wimal Ubhayasekera, Inés G. Muñoz, Gunnar Johansson, T.Alwyn Jones, Jerry Ståhlberg, Sherry L. Mowbray, GLIBS (SSF) network meeting, Tammsvik, Sweden 14-6 October, 2001

Arand, M., Dürk, H., Hangen, N., Cronin, A., Oesch, F., Hallberg, M., Zou, J., Bergfors, T., Jones, T. A. & Mowbray, S. L. (2001). 6th International ISSX Meeting, Munich.

A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2) Grantcharova, N., Ubhayasekera, W., Mowbray, S.L., McCormick, J.R. and Flärdh, K. , Procaryotic Development, American Society of Microbiology, summer 2002.

Properties of catalytic, linker and chitin-binding domains of insect chitinase. Yasuyuki Arakane, Qingsong Zhu, Sherry L. Mowbray, Wimal Ubhayasekera, Masahiro Matsumiya, Subbaratnam Muthukrishnan and Karl J. Kramer, 9th International Chitin and Chitosan Conference, Montreal, Canada, 27-30 August, 2003

The structure of RpiB from Mycobacterium tuberculosis - a part of the RAPID project. Annette Roos, Terese Bergfors, Torsten Unge, Sherry Mowbray, Alwyn Jones, Seventh Annual Conference of the Swedish Structural Biology Network, Tällberg, Sweden, 13 - 17 June, 2003

Ulrika’s poster from Tällberg, other posters from 2001, 2002

December, 2003 'Structure elucidation of an enzyme and its active site' Mr. Ubhaysekera was invited by the Sri Lanka Association for the Advancement of Science (SLAAS), to give a talk in the Auditorium of the Association in Colombo, Sri Lanka.

Structural studies of Phanerochaete chrysosporium cellobiohydrolases' Wimal Ubhayasekera, Inés G. Muñoz, T. Alwyn Jones, Gunnar Johansson, Jerry Stålberg and Sherry L. Mowbray, Experimental Biology 2003, San Diego, USA, Program 121 Glycobiology, Presentation number B42 121.1

'Getting structural information from proteins; homology modeling approach' Wimal Ubhayasekera and Sherry L. Mowbray, ISDSB 2003, Tsukuba, Japan, P-89, page 186 ISDSB

Glycoside hydrolase family 19 Brassica juncea chitinase crystal structures. Wimal Ubhayasekera, Ce Mun Tang, Terese Bergfors, Gunnar Berglund, , Mee-Len Chye and Sherry L. Mowbray Eigth Annual Conference of the Swedish Structural Biology Network, Tällberg, Sweden, 11-14 June, 2004

Students and Postdoctoral Fellows:

L. Brent Cole, post-doctoral fellow, 1988-1990, Ph.D. University of Oklahoma (1986), structure of the periplasmic ribose binding protein and mutants, later at Biocryst Inc., University of Alabama, currently project manager with Abbott Labs, Diagnostics Division, Dallas, TX.

Mi Ha Yuen, graduate student, 1988-1990, transferred to University of Minnesota, Ph.D. 1994.

Pete W. Dunten, post-doctoral fellow, 1989-1995, Ph. D. University of California, Berkeley (1989), structure and biochemistry of the periplasmic dipeptide-binding protein and biochemistry of the aspartate chemoreceptor. Now working for Hoffman-Laroche, NJ.

A. Joakim Björkman, graduate student, 1991-1998, structural studies of mutants and open, ligand-free forms of the ribose-binding protein, M.Sc. Uppsala University (Sweden; 1989), Ph.D. SLU, 25 September, 1998.

A. Malin Björkman (née Junerup), graduate student, 1992-2000, M.Sc. University of Uppsala (Sweden, 1992) biochemical studies of mutants of the aspartate chemoreceptor. M.Sc. June, 2000

Maria M. Flocco, post-doctoral fellow, 1991-1995, Ph. D. City University of New York (1989), aromatic-arginine interactions in proteins, structure of closed forms of the glucose/galactose binding protein (liganded and unliganded), murine cyclin. Currently head of department at Pfizer, UK.

Brian H. Shilton, post-doctoral fellow, 1992-1994, Ph. D. Queen’s University at Kingston, Ontario (1992) purification and crystallization of a soluble signaling fragment of the aspartate chemoreceptor, studies with a mutant maltose receptor; later working at the Biological Research Institute, Crete, now has a faculty position at University of Western Ontario, Canada.

Jill A. Sigrell (student, with Jones), 1994-1998, Structure of E. coli ribokinase, PhD 13 November, 1998.

Mats O. J. Sandgren (student, with Jones), Structure of the aspartate chemoreceptor. PhD, 2003

Alex Cameron (post-doctoral fellow, with Jones), 1993-1998, Structural studies of E. coli ribokinase. Currently working with Pharmacia in Milan.

Barnali Chaudhuri (student, with Jones), 1994-1999, Structure of the allose-binding protein. , PhD 29 October, 1998.

Mary Rose Hoja (student, with Jones), 1996-1997, Structural studies of the platelet-derived growth hormone receptor. Transferred to KI, Stockholm.

Jan Saras, post-doctoral fellow, 1997-2001. Structural studies of Band 4.1 and related proteins.

Inés Muñoz, graduate student, 1998-2002, joint with Jerry Stålberg. Structural studies of cellobiohydrolases, endoglucanases and dextranases.

Ulrika Magnusson, June 1998 - January, 2004. Structural studies of the platelet-derived growth hormone receptor and phosphatases. Conformational changes in periplasmic binding proteins. PhD, UU, 2003.

C. Evalena Andersson, December 1998 - March 2004. Structural studies of enzymes of ribose metabolism. PhD, UU, 2004.

Wimal Ubhayasekera, GLIBS student, 1999-present. Structural studies of carbohydrate-degrading enzymes. PhD, SLU, 2005.

Camilla Persson, co-supervisor with Arne Östman of the Ludwig Institute, 1998- 2003, Studies of PDGF and related protein tyrosine phosphatases

Frida Berg, Uppsala Graduate School in Biomedical Research, rotation project, Fall 2000.

Patrick Johansson (50% with Jones), 2001-present, genomics with Tuula Teeri's group, then studies of proteins from Mycobacterium tuberculosis.

Daniel Ericsson, SLU, rotation project, 10 weeks, Spring 2002.

Lena Henriksson (joint with T. Unge), Studies of proteins from Mycobacterium tuberculosis, June 2002-present.

Annette Roos, Studies of proteins from Mycobacterium tuberculosis, June 2002-present.

Adrian Suarez, Studies of proteins from Mycobacterium tuberculosis, January 2003-present.

Wojciech Krajewski Studies of proteins from Mycobacterium tuberculosis, July 2003-present.

Daniel Ericsson, Studies of proteins from Mycobacterium tuberculosis, September 2003-present.

Jonas Vasur, assistant to Jerry Ståhlberg, September 2003-present.

Henrik Ingvarsson, assistant to Torsten Unge, fall 2004-present

Christofer Björkelid, assistant to Torsten Unge, January, 2005-present

Martin Högbom, assistant to T. Alwyn Jones, February 2004-November 2004.

Evalena Andersson, April 2004-present.

Sanjeewani Sooriyaarachchi, graduate student, October 2004-present

Agata Naworyta, graduate student, October 2004-present

Eva Kowalinski, project student, January-June 2005, Structure and function studies of RpiB from Mycobacterium tuberculosis.

Maria Nygårds, 5 p project student from the Uppsala University program Molecular Biotechnology and Bioinformatics, June-August, 2005, Purification and crystallization of epoxide hydrolases (supervisor Agata Novoryta)