SHERRY LYNN MOWBRAY   

Address:    Swedish University of Agricultural Sciences

                  Department of Molecular Biology

                  Box 590, Biomedical Center

                  S-751 24 Uppsala, Sweden

                  Telephone: 46-18-471 49 90                     e-mail: MOWBRAY@xray.bmc.uu.se

Born:         December 18, 1954            (pn: 541218-1124)   

Nationality:   U. S. citizen

 

Education/qualifications: 

     B.Sc., Honours (Biochemistry), Queen's University at Kingston, Ontario, Canada, 1976

Ph.D., Chemistry (Biophysics), Massachusetts Institute of Technology, Cambridge, MA,      1983

Docent (associate professor) in biochemistry, Swedish University of Agricultural Sciences, 1992

     Examiner (examinator), Swedish University of Agricultural Sciences, 2008

 

Professional Experience:

Research assistant (1976-1978):  Structural studies of a polysaccharide from Mycobacterium smegmatis with Dr. D. J. Walton of the Department of Biochemistry, Queen's University, Kingston, Ontario, Canada 

         - Experience including organic synthesis; protein and polysaccharide purification; gas-liquid chromatography; NMR.

Graduate student (1979-1983):  X-ray crystallographic studies of periplasmic binding proteins involved in chemotaxis with Dr. G. A. Petsko of the Department of Massachusetts Institute of Technology, Cambridge, MA.

         - Experience including bacterial fermentation; protein purification, assay and analysis; protein crystallization; X-ray structure solution by multiple isomorphous replacement and molecular replacement.

Post-doctoral fellow  (1983-1987): Biochemical and crystallographic studies of the membrane-bound aspartate receptor involved in bacterial chemotaxis with Dr. D. E.  Koshland, Jr. of Department of Biochemistry and Dr. S.-H. Kim of the Department of  Chemistry, University of California, Berkeley, CA.

Experience including membrane protein purification and crystallization; amino acid, N-terminal and peptide analysis using HPLC; bacterial behavioral studies; cloning; DNA sequencing; site-directed mutagenesis; fluorescence and CD spectroscopy.

Assistant Professor (1987-1990): Biochemical and crystallographic studies of receptors and membrane proteins. Junior Investigator, Howard Hughes Medical Institute, Departments of Biochemistry and Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX. 

- Head of a research group of five people engaged in protein purification,  crystallization, structure solution and refinement, cloning and site-directed  mutagenesis. Also responsible for operation of the Hughes Institute's fermentation facility. Teach sections in various courses (Medical Biochemistry, Graduate Biochemistry, Advanced Protein Chemistry, Advanced Cell and Molecular Biology).

   Researcher (1990-1999): Biochemical and crystallographic studies of proteins. Department of Molecular Biology, Swedish University of Agricultural Sciences, Biomedical Center, Uppsala

             - Head of research group, graduate/undergraduate teaching

     University Lecturer (10 May, 1999-8 Sept, 1999):

            biochemistry, specialization in protein structure/function

     Professor (9 September, 1999-present):

            professor of biochemistry, Swedish University of Agricultural Sciences. Course organizer for 10 p (15 hp) course in Protein Technology, as well as leading research group.

            Co-director of the RAPID project (Rational Approaches to Pathogen Inhibitor Discovery) aimed at drug design and biology of Mycobacterium tuberculosis


Awards and Fellowships:

     National Merit Scholarship Honorary Award, 1972

     Bausch and Lomb Honorary Science Award, 1972

     Rhode Island State Scholarship, 1972

     Research Award from Sigma Xi, 1981

     Genentech Fellowship, 1982-83

     Jane Coffin Childs Memorial Fellowship, 1983-1986

     American Cancer Society Senior Fellowship 1986-1987

 

Other activities 

editorial board of the journal Receptor (appointed 1989)

editorial board of Journal of Biomedicine and Biotechnology, molecular biology section (appointed 2008)

member of the Faculty of 1000, Plant biochemistry & physiology sections, 2004-present

member of the steering committee for the Biotechnology program, Swedish University of Agricultural Sciences, 1999-2004

referee for various scientific journals, including Journal of Molecular Biology, Journal of Biological Chemistry, EMBO Journal, Journal of the American Chemical Society, Acta Crystallographica, Proceeding of the National Academy of Sciences (USA), Trends in Biochemical Sciences, FEBS Letters, Protein Science, and Structure, etc.

outside referee for various British and US funding agencies (NIH, NSF)

member of the Biotechnology review section of the Swedish Research Council, 2001-2003

member of the Chalmers Biotechnology graduate program referee board

member of the Advisory Council for the Swedish Foundation for Strategic Research 2003-2010

docent evaluation committee of the Faculty Natural Resources and Agricultural Sciences, Swedish University of Agricultural Sciences, alternate 2008-2010, regular member April, 2010-present.

Associated member, SciLifeLab in Uppsala, February, 2011.

 

Invited talks at international meetings, representative sample:

Gordon Conference on Bacterial Cell Surfaces, Keene, New Hampshire, July, 1985.

Cold Spring Harbor Symposium on Evolution on Biological Molecules, Cold Spring Harbor, New York, June, 1987.

Conference on Bacterial Locomotion and Sensory Transduction, Austin, Texas, January, 1991.

The Maltose System: Molecular Genetics and Cell Biology, Konstanz, Germany, September, 1991.

Gordon Conference on Bacterial Cell Surfaces, July 1992.

Chairperson of session, Gordon Conference on Diffraction Methods in Molecular Biology, June 1992.

Bacterial Locomotion and Signal Transduction, Austin, TX, 12-16 January, 1995, speaker and chair of session.

Molecular Recognition and Signaling, 19-21 December, 1995, Bath, England

Structural Biology in Sweden, 29 November, 1996, Uppsala, Sweden

Bacterial Locomotion and Signal Transduction, 9-13 January, 1997, Mexico (2 hour workshop on protein crystallization, presented with Mats Sandgren)

Symposium on Structure and Function of Cell Surface Proteins, University of Konstanz, Germany, 9-10 May, 1997 "Structure of periplasmic binding proteins as high affinity sites of bacterial ABC transporters"

Bacterial Locomotion and Signal Transduction, 16-20 January, 1999, Mexico (also 2 hour workshop on protein crystallization)

5th European Workshop on Crystallography of Biological Macromolecules, May, 1999 "How reproducible are structures?"

SBNet meeting at TŠllberg, Sweden, June, 1999, "Errors and reproducibility in protein x-ray structure determination"

International Union of Crystallography Conference, Glasgow, 8 August, 1999 "Errors and reproducibility in protein x-ray structure determination"

Chairperson of ÒOmicsÓ session, SBNet meeting at TŠllberg, Sweden, June, 2000.

Talk at Gordon Conference on Diffraction Methods in Molecular Biology, "Everybody makes mistakes: some thoughts on why, and what to do about it.Ó July 4, 2000

Plenary lecture, Bacterial Neural Networks, Obernai, France, June 2002 "Transmembrane signaling in chemotaxis"

Lecture, AsCA'03/Crystal-23 meeting, Broome, Australia, August 2003 "Enzymes of ribose metabolism: structure and mechanismÓ

October, 2006. ÔCatalysis and evolution of epoxide hydrolasesÕ at the yearly meeting of the SFBM in Uppsala.


Selected talks outside SLU (beginning Dec. 1994)

Stockholm University, 1 December, 1994 - Receptors in bacterial chemotaxis.

UTSW, Dallas, Texas 23 January, 1995 - The role of periplasmic binding proteins in chemotaxis and transport.

Karolinska Institute, Huddinge, 22 February, 1996 - Conformational changes determine the role of periplasmic binding proteins in chemotaxis and transport.

UmeΠUniversity, 12 October, 1996. Conformational changes determine the role of periplasmic binding proteins in chemotaxis and transport.

Karolinska Institute, 20 January, 1997 Conformational changes of periplasmic binding proteins in chemotaxis and transport.

University of Mainz, 4 August, 2000. Structure and function of epoxide hydrolases.

University of California, Berkeley, 21 April, 2004, Structure and function of proteins of ribose metabolism.

Stanford University, 23 April, 2004, Structure and function of proteins of ribose metabolism.

 

Pedagogical courses:

SLU departmental, 1997

Forskarutbildningskonferensen 30 September, 1999

Forskarutbildningskonferensen 26 October, 2000

Handledningskursen, 16-17 November, 2000

Forskarutbildningskonferensen 31 October, 2001

Forskarutbildningskonferensen, October, 2002

Forskarutbildningskonferensen, October, 2003

Forskarutbildningskonferensen, October, 2004

Forskarutbildningskonferensen, October, 2005

Betygskurs, December, 2007 – March, 2008

 

Instruction in graduate training courses outside SLU

EMBO Practical Course on Protein Crystallography, Uppsala, 27 May - 7 June, 1991

FEBS/EACMB Advanced Course ÒTechniques in Protein CrystallographyÓ, Aarhus, 9-18 June, 1992

Protein Engineering Course , Uppsala University, 11-14 January, 1993

Protein Engineering Course, University of Gšteborg, 20 January, 1994

Practical Protein Crystallization course, Uppsala, 21 September, 1999

Bioorganic Catalysis, Department of Biochemistry and Organic Chemistry, 2005-2010

 

Graduate students (as main supervisor):

Mi Ha Yuen, 1988-1990, transferred to University of Minnesota, Ph.D. 1994.

A. Joakim Bjšrkman, 1991-1998, structural studies of mutants  and open, ligand-free forms of the ribose-binding protein, M.Sc. Uppsala University (Sweden; 1989), Ph.D. SLU, 25 September, 1998.

A. Malin Bjšrkman (nŽe Junerup), 1992-2000, M.Sc. University of Uppsala (Sweden, 1992) biochemical studies of mutants of the aspartate chemoreceptor. M.Sc. June, 2000

Jill A. Sigrell, 1994-1998, Structure of E. coli ribokinase, PhD 13 November, 1998.

Mats O. J. Sandgren, 1997-2000, Structure of the aspartate chemoreceptor.

Ulrika Magnusson, June 1998 - January, 2004. Structural studies of the platelet-derived growth hormone receptor and phosphatases. Conformational changes in periplasmic binding proteins. PhD, UU, 2003.

C. Evalena Andersson, December 1998 - March 2004. Structural studies of enzymes of ribose metabolism. PhD, UU, 2004.

Wimal Ubhayasekera, 1999-2005. Structural studies of carbohydrate-degrading enzymes. PhD, SLU, 2005. Later, a post-doctoral fellow in the lab. Currently working at MAX and University of Copenhagen.

Annette Roos, June 2002-2007, Studies of proteins from Mycobacterium tuberculosis, PhD UU, September, 2007. Later, a post-doctoral fellow at the Structural Genomics Consortion, Oxford, UK. Now a post-doctoral fellow in the laboratory.

Adrian Suarez Covarrubias, January 2003-April 2008, Studies of proteins from Mycobacterium tuberculosis.

Wojciech Krajewski, July 2003-November 2008. Studies of proteins from Mycobacterium tuberculosis.

Daniel Ericsson, September 2003-2009. Studies of proteins from Mycobacterium tuberculosis.

Agata Naworyta, October 2004-2010, epoxide hydrolases.

Sanjeewani Sooriyaarachchi, October 2004-2010, Antimicrobial and binding proteins.

 

Graduate students (officially as assistant supervisor):

Jinyu Zou (with Jones), Improved methods for building models in electron density maps and their application to carbohydrate-binding proteins. PhD UU. May, 1995.

Barnali (Neel) Chaudhuri (with Jones), 1994-1999, Structure of the allose-binding protein. PhD 29 October, 1998. Curently assistant professor, Department of Structural Biology, SUNY Buffalo.

Mary Rose Hoja (with Jones), 1996-1997, Structural studies of the platelet-derived growth hormone receptor. Transferred to KI, Stockholm.

Camilla Persson (with Arne …stman of the Ludwig Institute), 1998- 2003, Studies of PDGF and related protein tyrosine phosphatases

InŽs Mu–oz (with Jerry StŒhlberg), 1998-2002, Structural studies of cellobiohydrolases, endoglucanases and dextranases.

Patrik Johansson (with Jones), 2001-2006, genomics with Tuula Teeri's group, then studies of proteins from Mycobacterium tuberculosis. Currently working at EMBL, Germany.

Lena Henriksson (joint with T. Unge), June 2002-2007. Studies of proteins from Mycobacterium tuberculosis, PhD UU, November, 2007.

Jonas Vasur, assistant to Jerry StŒhlberg, September 2003-present. Studies of celluases.

Henrik Ingvarsson, assistant to Torsten Unge, 11 July 2004-present. Studies of proteins from Mycobacterium tuberculosis.

Christofer Bjšrkelid, assistant to Torsten Unge, January, 2005-present, Studies of proteins from Mycobacterium tuberculosis.

 

Postdoctoral Fellows:

L. Brent Cole, 1988-1990, Ph.D. University of Oklahoma (1986), structure of the periplasmic ribose binding protein and mutants, later at Biocryst Inc., University of Alabama, currently project manager with Abbott Labs, Diagnostics Division, Dallas, TX.

Pete W. Dunten, 1989-1995, Ph. D. University of California, Berkeley (1989), structure and biochemistry of the periplasmic dipeptide-binding protein and biochemistry of the aspartate chemoreceptor. Then working for Hoffman-Laroche, NJ. Now beamline scientist, Stanford Synchrotron Radiation Laboratory.

Maria M. Flocco, 1991-1995, Ph. D. City University of New York (1989), aromatic-arginine interactions in proteins, structure of closed forms of the glucose/galactose binding protein (liganded and unliganded), murine cyclin. Currently Director & Head Structural Biology, Pfizer, UK.

Brian H. Shilton, 1992-1994, Ph. D. QueenÕs University at Kingston, Ontario (1992) purification and crystallization of a soluble signaling fragment of the aspartate chemoreceptor, studies with a mutant maltose receptor; later working at the Biological Research Institute, Crete, now a professor at University of Western Ontario, Canada.

Alex Cameron (with Jones), 1993-1998, Structural studies of E. coli ribokinase. Currently working with Pharmacia in Milan.

Jan Saras, post-doctoral fellow, 1997-2001. Structural studies of Band 4.1 and related proteins.

Evalena Andersson, April 2004-2006. Studies of proteins from Mycobacterium tuberculosis. Currently a post-doctoral fellow, SLU.

Martin Hšgbom (with Jones), February 2004-November 2004. Currently a post-doctoral fellow, KI.

Wimal Ubhayasekera, 2005-2009.

Annette Roos, 2009-present, proteases of Mycobacterium tuberculosis.

Ana Laura Stern, 2009-present. Enzymes of the pentose phosphate pathway.

Agata Naworyta 2010-present, proteases of Mycobacterium tuberculosis.

Sanjeewani Sooriyaarachchi, 2010-present

 

Other supervision:

Frida Berg, Uppsala Graduate School in Biomedical Research, rotation project, Fall 2000.

Fiona McArthur, visiting from Canada, for expression, purification and analysis of the RfaE enzyme of bacterial cell-wall synthesis. Fall, 2001.

Daniel Ericsson, SLU, rotation project, 10 weeks, Spring 2002. Studies of proteins from Mycobacterium tuberculosis, September, 2003-present.

Eva Kowalinski, project student, January-June 2005, Structure and function studies of RpiB from Mycobacterium tuberculosis.

Maria NygŒrds, 5 p project student from the Uppsala University program Molecular Biotechnology and Bioinformatics, June-August, 2005, Purification and crystallization of epoxide hydrolases (supervisor Agata Naworyta).

Ana Laura Stern, PhD student visiting from University of Buenos Aires, Sep 2008 to Feb 2009, and again, August-December 2009.

 

PhD thesis committees:

Jamie McKnight, University of Texas, Southwestern, 1990. Chairman.

Laura Lark, University of Texas Southwestern, 1991.

Anders Holmgren, Swedish Agricultural University, 1992. Chairman.

Thomas Taylor, Swedish Agricultural University, 1996, reserve.

Arnold Andersson, Swedish Agricultural University, 1996.

Kristina BŠckbro, Uppsala University, 31 May 1997

Christer Wikner, Karolinska Institutet, 30 May 1997

Tomas Hansson, Uppsala University, 16 May 1998. Chairman.

Christophe Thibideau, Uppsala University, 8 February, 1999. Chairman.

Jeff Abramson, Uppsala University, April, 2001

Devapriya Choudhury, Swedish University of Agricultural Sciences, May, 2001

Louse Krafft, Karolinska Institute, Dec 2001

Priit VŠjamŠe, Uppsala University, 20 December, 2002

Daniel Nšteberg, Uppsala University, 7 March, 2003

Isabella Feierberg, Uppsala University, April, 2003

Alona Pavlova, Swedish University of Agricultural Sciences, 12 June, 2003

Lovisa Afzelius, Uppsala University, December, 2003

Anton Poliakov, Uppsala University, April, 2004

Gunilla Carlsson, Uppsala University, 22 September, 2004

Lars HildŽn, Swedish University of Agricultural Sciences, 7 October, 2004, Chairman

Emanuel Smeds, Uppsala University, 21 January, 2005

Dan Backman, Uppsala University, 3 June, 2005

sa M. Kallas, Royal Institute of Technology (KTH), 24 May, 2006

Anu Nutt, Uppsala University, 31 May, 2006

Aguda Adeleke Halilu, Uppsala University, 8 November, 2006

Azmiri Sultana, Karolinska Institute, 15 December, 2006

Elisabeth Wahlberg, Royal Institute of Technology (KTH), 15 December, 2006

Martin Almlšf, Uppsala University, 19 January, 2007

Marian Novotny, Uppsala University, 23 March, 2007

Christopher Adams, Uppsala University, 28 May, 2007

Stina Lundgren, Karolinska Institute, 1 February, 2008

Daniel gren, Karolinska Institute, 30 January, 2009

Sakesit Chumnarnsilpa, Uppsala University, 23 March, 2009

Helena Strombergsson, Uppsala University, 27 March, 2009

Gšran Dahl, Uppsala University, 17 April, 2009

Pavel Plevka, Uppsala University, 15 May, 2009

Marvin Seibert, Uppsala University, 20 April, 2010

Louise Egblad, Uppsala University, 26 May, 2011

 

Licenciat thesis committees

Louse Krafft, Karolinska Institute, 2001

Jimmy Lindberg, Uppsala University, 8 February, 2002

Azmiri Sultana, Karolinska Institute, 13 Jun, 2005

Linda Arnfors, Karolinska Institute, 13 October, 2005

Rebecka Hjelm, Uppsala University, 14 March, 2007

 

PhD thesis examiner

examiner, JP Morth, Aarhus Universitry, Aarhus Denmark, 8 February, 2005

examiner, Ravindra Singh Prajapati, Indian Institute of Science, February, 2007

examiner, Ingunn Alne-Hoell, Norwegian University of Life Sciences, June, 2009

examiner, Jason van Rooyen, University of Cape Town, June, 2010

 

MasterÕs thesis examiner

Helena HŠggblad, Protein homology modeling in ICM-assessment of model quality and reliability, Molecular Biotechnology program, Uppsala University School of Engineering, supervisor Maria Flocco (Pharnacia), 20 June, 2000

Linda Johansson, Adding a tag to thioredoxin bearing selenomethionine, SLU Biotechnology program, supervisor Elias Arner, Karolinska Institutet ( Department of Medical Biochemistry and Biophysics, Karolinska Institutet), June 2001

Annette Roos, Structure-function studies of proteins from Mycobacterium tuberculosis, supervisor Ted Baker, University of Aukland, New Zeeland, spring 2002

Maria Bergsland, Assay of viral counts, supervisor Christine Dartsch, Astrazeneca, December, 2002

Karin Andersson, Wild-type presenilin-1 sensitises cells to apoptotic stimuli, supervisor Maria Ankarcrona, PhD. Karolinska Institutet, Neurotec, Section of Experimental Geriatrics, Huddinge. 13 June, 2003

Kerstin Ahlgren, Site directed mutagenesis of L-CPT 1 and the effect on beta-oxidation in transient transfected liver cells, supervisors Bjšrn Kull & Magnus Jansson, Department of Biology, Biovitrum,  June, 2004.

Anna Wahren, Characterization of SIK2 kinase effects on insulin receptor signaling and glucose metabolism, supervisor Eva Rupp Thuresson, Dep. of Biology, Biovitrum, 16 March, 2005.

Maria Ekman, Unravelling post mortem changes in cattle muscle using proteomics, supervisor, Matforsk, Norway.

Johan Winquist, Characteristics of PrrA-C binding to its DNA targets in the photosynthetic bacterium Rhodobacter sphaeroides. Supervisor Dr M.K. Phillips-Jones, University of Leeds, UK.

Annlouise Mickelsen, Water excluded aqueous two phase systems, Supervisors: Ronnie Palmgren and Elisabeth Hallgren, GE Healthcare, June 2007.

Helen Persson, Analysis of casein in food by the use of biosensor-based technology, supervisor Charlotta Engdahl Axelsson, Dr. R & D Manager Microbiology section, Analycen AB, Lidkšping, 2007.

Jesper Svedberg, Bio-Booze Boosting, supervisor Jerry StŒhlberg, SLU, spring 2008.

 

Posters since 1990 and conferences attended by group members (not very complete):

The 1.6  refined X-ray structures of the periplasmic ribose and glucose/galactose receptors involved in transport and chemotaxis in E. coli. S.L. Mowbray. American Crystallographic Association, Toledo, 21-26 July, 1991.

Mutations of the E. coli aspartate/maltose receptor which affect aspartate binding. M. Junerup, N. Vangipurnam, Q. Vu, V. Feiz, P. Dunten and S. Mowbray. The Maltose System: Molecular Genetics and Cell Biology, 1-6 Sept. 1991, Konstanz, Germany.

Mutants of the ribose receptor that affect chemotaxis and transport. J. Bjšrkman, A. Binnie, L.B. Cole and S.L. Mowbray. Understanding Protein Folding, Novum Research Center, Stockholm, 24-28 August, 1992.

Arginine NE and its interactions with the aromatic rings of phe, tyr and trp in proteins. M.M. Flocco and S.L. Mowbray. Understanding Protein Folding, Novum Research Center, Stockholm, 24-28 August, 1992.

In vivo and in vitro studies of mutant Tar receptor in Escherichia coli. M. Junerup, N. Vangipurnam, Q.Vu, V. Feiz, P. Dunten and S.L. Mowbray. Understanding Protein Folding, Novum Research Center, Stockholm, 24-28 August, 1992.

Arginine NE and its interactions with the aromatic rings of phe, tyr and trp in proteins. M.M. Flocco and S.L. Mowbray. American Crystallographic Association, Pittsburgh, 9-14 August, 1992.

Crystallization of the periplasmic dipeptide-binding protein from E. coli. P. Dunten and S.L. Mowbray. Bacterial Locomotion and Signal Transduction, Austin, 14-18 January, 1993.

In vivo and in vitro studies of mutant Tar receptor in Escherichia coli. M. Junerup, N. Vangipurnam, Q.Vu, V. Feiz, P. Dunten and S.L. Mowbray. Bacterial Locomotion and Signal Transduction, Austin, 14-18 January, 1993.

Expression and purification of the cytoplasmic domain of the Tar receptor from S. typhimurium. B.H. Shilton, P.W. Dunten and S.L. Mowbray. Bacterial Locomotion and Signal Transduction, Austin, 14-18 January, 1993.

Three dimensional structure of the close unliganded periplasmic glucose/galactose receptor from Salmonella typhimurium  M. Flocco and S. Mowbray, European Workshop on Crystallography of Biological Macromolecules, Como, Italy, 24-28 May, 1993.

M. Flocco, Understanding Signal Transduction, Novum Research Park, Stockholm, 17-20 June, 1993, participant.

P. Dunten, CCP4 Study Weekend on Molecular Replacement, Daresbury, England, 6-8 Jan, 1994, participant.

P. Dunten, York Course on Protein Structure Refinement, York, England, 9-12 Jan, 1994, paricipant.

B. Shilton, EMBO Data Collection Course, Cambridge, England, 27 Feb - 5 Mar, 1994, participant.

Three dimensional structure of the close unliganded periplasmic glucose/galactose receptor from Salmonella typhimurium  M. Flocco and S. Mowbray, Gordon Research Conference on Diffraction Methods in Molecular Biology, Andover, NH, 19-24 June, 1994.

Structure of the periplasmic receptor for dipeptides in E. coli. P. Dunten,  Gordon Research Conference on Bacterial Cell Surfaces, Keene, NH, 10-15 July, 1994.

Three dimensional structure of the close unliganded periplasmic glucose/galactose receptor from Salmonella typhimurium  M. Flocco and S. Mowbray  Bacterial Locomotion and Signal Transduction, Austin, 12-16 January, 1995.

Characterization and crystallization of the cytoplasmic portion  of the Tar chemoreceptor from S. typhimurium. Mats O.J. Sandgren, Brian H. Shilton, Pete W. Dunten and Sherry L. Mowbray Bacterial Locomotion and Signal Transduction, Austin, 12-16 January, 1995.

Crystallization of the cytoplasmic portion  of the Tar chemoreceptor from S. typhimurium. Mats Sandgren, Brian H. Shilton and Sherry L. Mowbray  European Crystallographic Meeting, Lund, Sweden, 6-11 August, 1995.

Ribokinase: preliminary X-ray crystallography studies. Jill A. Sigrell, Alexander D. Cameron and Sherry L. Mowbray European Crystallographic Meeting, Lund, Sweden, 6-11 August, 1995.

Probing protein-protein interactions: Structural studies on E. coli ribose-binding protein mutants that affect chemotaxis and transport. Sherry L. Mowbray, A. Joakim Bjšrkman, R. Alan Binnie, Huide Zhang and Mark A. Hermodson. European Crystallographic Meeting, Lund, Sweden, 6-11 August, 1995.

Crystal structures and solution conformations of a dominant-negative mutant of Escherichia coli  maltose-binding protein. Brian H. Shilton, Howard A. Shuman, and Sherry L. Mowbray International Union of Crystallography, Seattle, 10-17 August, 1996.

The use of SeMet as a derivative in the structure determination of Ribokinase from E. coli."  Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L., presented at the summer school "Understanding Protein Motions", September 1996, Stockholm, Sweden.

Course on Data Collection, Cambridge, 11/96 Jill Sigrell

Course on Maximum Likelihood, Barnali Chauduri, around 10/96

Conformational changes of periplasmic binding proteins in chemotaxis and transport. Joakim Bjšrkman, Maria Flocco, Brian Shilton, Pete Dunten and Sherry Mowbray. BLAST meeting, Mexico, 9-13 January, 1997.

Crystallisation of the cytoplasmic portion of tar chemoreceptor from S. typhimurium Mats O.J. Sandgren, Brian H. Shilton, Pete W. Dunten, Sherry L. MowbrayBLAST meeting, Mexico, 9-13 January, 1997.

Conformational changes of ribose-binding protein in chemotaxis and transport. Joakim Bjšrkman and Sherry Mowbray. SBNet meeting, TŠllberg, Sweden, 6-9 June, 1997.

Expression of the Platelet-derived Growth Factor alpha-Receptor. Mary-Rose Hoja, K. Miyazawa, Arne …stman, C. Heldin, T. A. Jones and S. L. Mowbray, SBNet meeting, TŠllberg, Sweden, 6-9 June, 1997.

Crystallisation of the cytoplasmic portion of tar chemoreceptor from S. typhimurium. Mats O.J. Sandgren, Brian H. Shilton, Pete W. Dunten, Sherry L. MowbraySBNet meeting, TŠllberg, Sweden, 6-9 June, 1997.

Structural studies on D-allose binding protein from Escherichia coli. B. Chauduri, Junsang Ko, C. Park, T. A. Jones and Sherry L. MowbraySBNet meeting, TŠllberg, Sweden, 6-9 June, 1997.

A dedicated expression lab in Uppsala. Eva Davey, Petra FranzŽn and Sherry L. Mowbray. SBNet meeting, TŠllberg, Sweden, 6-9 June, 1997.

E. coli ribokinase - a new fold gives new ideas about kinase function. Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L., presented at European Crystallography Meeting17, August 1997, Lisbon, Portugal.

A binding protein-dependent ABC transport system for maltose in Alicyclobacillus acidocaldarius. Anja Herrmann, Mats Sandgren, Sherry Mowbray, Erwin Schneider.

Ribose makes ribokinase fly. Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L. presented at the Structural Biology Network (SBNet) Second Annual Conference in TŠllberg, Sweden, May 1998.

Mats Sandgren,  Anya Hermann, Sherry Mowbray, and Erwin Schneider, meeting title?, March, 1998.

Cellulose Binding in Family 7 Cellulases: P. Chrysosporium Cbh 58 And T. reesei CBH 1 And EG 1. Jerry Stahlberg, Ines Munoz and Sherry L. Mowbray. 7th International Conference on Biotechnology in thePulp and Paper Industry" Vancouver, June 16-19, 1998

Cellulose Binding in Family 7 Cellulases: P. Chrysosporium Cbh 58 And T. reesei CBH 1 And EG 1. I.G. Munoz, J. StŒhlberg,  C. Divne, G. Kleywegt, H. Henriksson, G. Johansson, S.L. Mowbray and T.A. Jones. Conference on ÒThe role of cell wall degrading enzymes of Trychoderma harzianum in bioocontrolÓ. 31 July- 3 August, 1998. Tynset, Norway.

A progress report on the conformational changes and mechanism of E. coli ribokinase. EvaLena Andersson and Sherry Mowbray, Meeting of Structural Biology Network (SBNet) of the SwedishFoundation for Strategic Research, 11-14 June, 1999

Purification and crystallisation of PDGF alfa & beta and DEP-1 protein tyrosine phosphatase Ulrika Magnusson, Camilla Persson, Arne …stman, Alwyn Jones and Sherry Mowbray, Meeting of Structural Biology Network (SBNet) of the Swedish Foundation for Strategic Research, 11-14 June, 1999

X-ray structure of CBH 58 from Phanerochaete chrysosporium" InŽs G. Mu–oz, Jerry StŒhlberg, Gunnar Johansson, Gšran Pettersson, Sherry L. Mowbray and T. Alwyn Jones, Meeting of Structural Biology Network (SBNet) of the Swedish Foundation for Strategic Research, 11-14 June, 1999

Structural studies of carbohydrate-degrading enzymes. Sherry Mowbray, Ines Munoz, Jerry Stahlberg. GLIBS network meeting, September, 1999

New insights into the enzymatic mechanism of epoxide detoxi­fication by epoxide hydrolases revealed by three-dimensio­nal structure analysis Michael Arand, Jinyu Zou, Martin Hallberg, Terese Bergfors, Heike DŸrk, Heike Hemmer, Franz Oesch, Sherry L. Mowbray and T. Alwyn Jones. German Association of Pharmacologists and Toxicologists, spring 2000.

The structure of allose-binding protein from E. coli. Magnusson U, Jones TA, Mowbray SL., Fourth Annual Conference of the Swedish Structural Biology Network, TŠllberg, Sweden, 9 - 12 June, 2000

New insights into the function of E. coli ribokinase. C. Evalena Andersson, Sherry L Mowbray and T. Alwyn Jones, Fourth Annual Conference of the Swedish Structural Biology Network, TŠllberg, Sweden, 9 - 12 June, 2000

Structural studies of two carbohydrate-degrading enzymes. Wimal Ubhayasekera,Sherry Mowbray, Ines Munoz, Jerry Stahlberg, Alwyn Jones, Gunnar Johansson, Istvan Szabo, Sabah Mahdi, Fourth Annual Conference of the Swedish Structural Biology Network, TŠllberg, Sweden, 9 - 12 June, 2000

Structural studies of carbohydrate-degrading enzymes. Wimal Ubhayasekera, Sherry Mowbray, Ines Munoz, Jerry Stahlberg. GLIBS network meeting, 14-17 October, 2000.

Arand, M., Zou, J., Hallberg, M., Bergfors, T., DŸrk, H., Hemmer, H., Oesch, F., Mowbray, S. L. & Jones, T. A. (2000). 41st Spring Meeting of the German Society for Experimental and Clinical Pharmacology and Toxicology, Mainz.

Arand, M., Zou, J., Hallberg, M., Bergfors, T., DŸrk, H., Hemmer, H., Oesch, F., Mowbray, S. L. & Jones, T. A. (2000). 13th International Symposium on Microsomes and Drug Oxidation, Stresa, Italy.

Primary sequence determinants responsible for PDGF R site-selective dephosphorylation by the rPTP DEP-1. Camilla Persson1, Marina Kovalenko1, Ulla Engstršm1, Sherry Mowbray2 and Arne …stman, presented at Tyrosine phosphorylation and cell signaling', Cold Spring Harbour, NY,  May 16-20 2001

Structural studies of  Allose-binding Protein, Ulrika Magnusson, T. Alwyn Jones and Sherry L. Mowbray, presented at the Fifth international school on Crystallography, Como, Italy, May13-17, 2001

3D-Structures of Phanerochaete chrysosporium cellobiohydrolases (Pc_Cel7s)

         Wimal Ubhayasekera, InŽs G. Mu–oz, Gunnar Johansson, T. Alwyn Jones, Jerry StŒhlberg, Sherry L. Mowbray, 6th International School on Crystallography of Biological Macromolecules, Villa Erba, Como, Italy, 13-17 May 2001

3D-Structures of Phanerochaete chrysosporium cellobiohydrolases (Pc_Cel7s)

         Wimal Ubhayasekera, InŽs G. Mu–oz, Gunnar Johansson, T.Alwyn Jones, Jerry StŒhlberg, Sherry L. Mowbray, 4th Carbohydrate Bioengineering Meeting, Royal Institute of Technology, Stockholm, Sweden, 10th – 13th June 2001.

3D-Structures of family 7 glycoside hydrolases from Phanerochaete chrysosporium

Wimal Ubhayasekera, InŽs G. Mu–oz, Gunnar Johansson, T.Alwyn Jones, Jerry StŒhlberg, Sherry L. Mowbray, Gordon Research Conference on ÔCellulases and CellulosomesÕ, Proctor Academy, Andover, New Hampshire, USA, 29 July – 02 Aug 2001.

3D-Structures of family 7 glycoside hydrolases from Phanerochaete chrysosporium. Wimal Ubhayasekera, InŽs G. Mu–oz, Gunnar Johansson, T.Alwyn Jones, Jerry StŒhlberg, Sherry L. Mowbray, GLIBS (SSF) network meeting, Tammsvik, Sweden 14-6 October, 2001

Arand, M., DŸrk, H., Hangen, N., Cronin, A., Oesch, F., Hallberg, M., Zou, J., Bergfors, T., Jones, T. A. & Mowbray, S. L. (2001). 6th International ISSX Meeting, Munich.

A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2) Grantcharova, N., Ubhayasekera, W., Mowbray, S.L., McCormick, J.R. and FlŠrdh, K. , Procaryotic Development, American Society of Microbiology, summer 2002.

Properties of catalytic, linker and chitin-binding domains of insect chitinase. Yasuyuki Arakane, Qingsong Zhu, Sherry L. Mowbray, Wimal Ubhayasekera, Masahiro Matsumiya, Subbaratnam Muthukrishnan and Karl J. Kramer, 9th International Chitin and Chitosan Conference, Montreal, Canada, 27-30 August, 2003

The structure of RpiB from Mycobacterium tuberculosis - a part of the RAPID project. Annette Roos, Terese Bergfors, Torsten Unge, Sherry Mowbray, Alwyn Jones, Seventh Annual Conference of the Swedish Structural Biology Network, TŠllberg, Sweden, 13 - 17 June, 2003

UlrikaÕs poster from TŠllberg, other posters from 2001, 2002

December, 2003 'Structure elucidation of an enzyme and its active site' Mr. Ubhaysekera was invited by the Sri Lanka Association for the Advancement of Science (SLAAS), to give a talk in the Auditorium of the Association in Colombo, Sri Lanka.

Structural studies of Phanerochaete chrysosporium cellobiohydrolases' Wimal Ubhayasekera, InŽs G. Mu–oz, T. Alwyn Jones, Gunnar Johansson,  Jerry StŒlberg and Sherry L. Mowbray, Experimental Biology 2003, San  Diego, USA, Program 121 Glycobiology, Presentation number B42 121.1

 'Getting structural information from proteins; homology modeling approach' Wimal Ubhayasekera and Sherry L. Mowbray, ISDSB 2003, Tsukuba, Japan,  P-89, page 186 ISDSB

Glycoside hydrolase family 19 Brassica juncea chitinase crystal structures. Wimal Ubhayasekera, Ce Mun Tang, Terese Bergfors, Gunnar Berglund, , Mee-Len Chye and Sherry L. Mowbray Eigth Annual Conference of the Swedish Structural Biology Network, TŠllberg, Sweden, 11-14 June, 2004

 


Publications Sherry L. Mowbray:

 

1.     A compound representing the D-glycerate terminus of the methylglucose- containing polysaccharide of Mycobacterium smegmatis.  B. K. Hunter, S. L. Mowbray and D.J. Walton. Biochemistry 18, 4458-65 (1979)

 

2.     Preliminary X-ray data for the galactose binding protein of Salmonella  typhimurium.  T. Alber, S. Mowbray, M. Fahnestock and G. A. Petsko. J. Mol. Biol., 147, 471-4 (1981)

 

3.     Preliminary X-ray data for the ribose binding protein of Salmonella typhimurium. S. Mowbray and G. A. Petsko.  J. Mol. Biol. 160, 545-7 (1982)

 

4.     The introduction of specific sites for heavy metal binding in a crystalline protein. S. Mowbray and G. A. Petsko.  J. Biol. Chem. 258, 5634-7 (1983)

 

5.     The X-ray structure of the periplasmic galactose-binding protein of Salmonella typhimurium at 3  resolution. S. Mowbray and G. A. Petsko. J. Biol. Chem. 258, 7991-7 (1983)

 

6.     Purification and characterization of the aspartate chemotaxis receptor. D. L. Foster, S. L. Mowbray, B. K. Jap and D. E. Koshland, Jr. J. Biol Chem. 260,11706-10 (1985)

 

7.     Proteolytic fragments identified with functional domains of the aspartate chemoreceptor.  S. L. Mowbray, D. L. Foster and D. E. Koshland, Jr. J. Biol. Chem. 260, 11711-8 (1985)

 

8.     Additive and independent responses in a single receptor: aspartate and maltose on the Tar protein. S. L. Mowbray and D. E. Koshland, Jr. Cell  50, 171-180 (1987)

       

9.     Transmission of regulatory conformational changes through proteins. P. E. Thorsness, S. L. Mowbray and D. E. Koshland, Jr. Cold Spring  Harbor Symp. Quant.  Biol., 52, 623-630 (1987)

 

10. Preliminary X-ray data  for  the ribose-binding protein from Escherichia coli. 

        M. Mahendroo, L. B. Cole and S. L. Mowbray  J. Mol. Biol., 211, 689-690 (1990)

 

11.  Periplasmic and membrane receptors of bacterial chemotaxis. S. L. Mowbray, in Receptor Purification, Vol. 2, Ed. G. Litwack, Humana Press, Clifton, N. J. 393-411  (1990)

 

12.  Structure of the periplasmic glucose/galactose receptor of Salmonella typhimurium at 2.4   resolution. S. L. Mowbray, R. D. Smith and L. B. Cole, Receptor 1, 41-54  (1990)

        Includes cover picture.

 

13.  Mutations of the aspartate receptor of Escherichia coli which affect aspartate binding.

        S. L. Mowbray and D. E. Koshland, Jr.  J. Biol. Chem, 265, 15638-15643 (1990)

 

14.  Reconstitution of the bacterial chemotaxis signal transduction system from purified components. E. G. Ninfa, A. Stock, S. Mowbray and J. Stock J. Biol. Chem., 266, 9764-9770 (1991) 

 

15.  The 1.7   X-ray structure of the periplasmic ribose receptor of Escherichia coli.

        S. L. Mowbray and L. B. Cole, J. Mol. Biol., 225, 155-175 (1992)

 

16.  The ribose and glucose-galactose receptors: competitors in bacterial chemotaxis. S. L. Mowbray , J. Mol. Biol, 227, 418-440 (1992)

        Includes cover picture for 5 October issue, which was subsequently used as part of the JMB sales brochure.

 

17.  Functional mapping of the surface of Escherichia coli  ribose-binding protein: mutations which affect chemotaxis and transport. R. A. Binnie, H. Zhang, S. Mowbray and M. A. Hermodson, Protein Science, 1, 1642-1651 (1992)

 

18.  Crystallization and preliminary X-ray analysis of the periplasmic dipeptide-binding protein from Escherichia coli.  P. Dunten, J.H. Harris, V. Feiz and S.L. Mowbray, J. Mol. Biol. 231, 145-147 (1993)

 

19. Structural analysis of the purine repressor, an E. coli DNA-binding protein. M.A. Schumacher, J.R. Macdonald, J. Bjšrkman, S.L. Mowbray and R.G. Brennan, J. Biol. Chem. 268, 12282-12288 (1993)

 

20.  The 1.7   refined X-ray structure of the periplasmic glucose/galactose receptor of Salmonella typhimurium. J. Zou, M.M. Flocco and S. L. Mowbray, J. Mol. Biol. 233, 739-752 (1993)

 

21. Planar stacking interactions of arginine and aromatic side chains in proteins. M.M. Flocco and S.L. Mowbray, J. Mol. Biol. 235 709-717 (1994)

 

22. An evaluation of the use of databases in protein structure refinement. J. Zou and S.L. Mowbray, Acta. Cryst. D50, 237-249 (1994)

 

23. The 1.9  x-ray structure of a closed unliganded form of the periplasmic glucose/galactose receptor from Salmonella typhimurium. M.M. Flocco and S.L. Mowbray, J. Biol. Chem. 269, 8931-8936 (1994)

 

24. Identical mutations at corresponding positions in two homologous proteins with non-identical effects. A.J. Bjšrkman, R.A. Binnie, L.B. Cole, H. Zhang, M.A. Hermodson and S.L. Mowbray, J. Biol. Chem. 269 , 11196-11200 (1994)

 

25. Probing protein-protein interactions: the ribose-binding protein in bacterial transport and

        chemotaxis. A. J. Bjšrkman, R. A. Binnie, H. Zhang, L. B. Cole, M. A. Hermodson, and S. L. Mowbray, J. Biol. Chem , 269, 30206-30211 (1994)

 

26. Sugar recognition by glucose/galactose-binding protein: evaluation of binding energetics from molecular dynamics simulations. J. qvist and S. L. Mowbray, J. Biol. Chem , 270, 9978-9981 (1995)

 

27. Simple models for the analysis of binding protein-dependent transport systems. B.H. Shilton and S. L. Mowbray, Protein Science 4, 1346-1355 (1995)

 

28. Ca-based torsion angles: a simple tool to analyze protein conformational changes. M.M. Flocco and S. L. Mowbray, Protein Science, 4, 2118-2122 (1995)

 

29. Strange bedfellows: interactions between acidic side chains in proteins. M. M. Flocco and Sherry L. Mowbray, J. Mol. Biol, 254, 96-105 (1995)

 

30. Crystal structure of the dipeptide binding protein from Escherichia coli involved in active transport and chemotaxis. P. Dunten and S.L. Mowbray, Protein Science, 4, 2327-2334 (1995)

 

31. Modeling of the structure of the Haemophilus influenzae heme-binding protein suggests a mode of heme interaction. P. Dunten and S.L. Mowbray, Protein Science, 4, 2335-2340 (1995)

 

32. Bacterial chemotaxis: a field in motion. A.M. Stock and S.L. Mowbray, Current Opinion in Structural Biology, 5, 744-751 (1995)

 

33. Conformational changes of three periplasmic receptors for bacterial chemotaxis and transport: the maltose-, glucose/galactose- and ribose-binding proteins. Shilton, B.H., Flocco, M.M., Nilsson, M. and Mowbray, S.L. J. Mol. Biol. 264, 350-363 (1996)

 

34. Crystal structures and solution conformations of a dominant-negative mutant of Escherichia coli maltose-binding protein. Shilton, B.H., Shuman, H.A. & Mowbray, S.L. J. Mol. Biol. 264, 364-376 (1996)

 

35. Purification, characterization and crystallization of the ribokinase of Escherichia coli. Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L. Protein Science, 6, 2474-2476 (1997)

 

36. Structure of Escherichia coli ribokinase in complex with ribose and dinucleotide determined to 1.8  resolution: insights into a new family of kinase structures. Sigrell, J.A., Cameron, A.D., Jones, T.A. and Mowbray, S.L., Structure, 6, 183-193 (1998)

 

37. Multiple open forms of ribose-binding protein trace the path of its conformational change. Bjšrkman, A.J. and Mowbray, S.L. J. Mol. Biol. 279, 651-664 (1998)

 

38. Chemotaxis receptors: a progress report on structure and function, Mowbray, S.L. and Sandgren, M.O.J. J. Struct. Biol., 124, 257-275 (1998). invited review (includes cover picture), ed. Martin Kessel and Alasdair Steven.

 

39. Structure of D-allose binding protein from Escherichia coli bound to allose at 1.8  resolution. Chaudhuri, B.N., Ko, J., Park, C., Jones, T.A. and Mowbray, S.L. J. Mol. Biol. 286, 1519-1531 (1999).

 

40. Macroseeding: a real life success story, S. Mowbray in "Crystallization of Proteins: Techniques, Strategies, and Tips. A Laboratory Manual", IUL Biotechnology Series. ed. Bergfors, T. (1999), pp. 155-162.

 

41. Bacterial chemoreceptors: recent progress in structure and function. Mowbray, S.L. Molecules and Cells, 2, 115-118, (1999), invited review

 

42. Errors and reproducibility in electron-density map interpretation. Mowbray, S.L., Helgstrand, C., Sigrell, J., Cameron, A.D., Jones, T.A. Acta Crystallographica, D55, 1309-19 (1999).

 

43. Induced fit on sugar binding activates ribokinase. Sigrell, J.A., Cameron, A.D. and Mowbray, S.L. J. Mol. Biol. 290, 1009-1018 (1999).

 

44. Conformational changes of ribose-binding protein and two related repressors are tailored to fit the functional need. Mowbray, S.L. and Bjšrkman, A.J. J. Mol. Biol., 294, 487-499 (1999).

 

45. Structure of Aspergillus niger epoxide hydrolase at 1.8  resolution: Implications for the structure and function of the mammalian microsomal class of epoxide hydrolases. Zou, J, Hallberg, B. M., Bergfors, T., Oesch, F., Arand, M., Mowbray, S.L., Jones, T.A., Structure Fold Des 8, 111-122 (2000).

 

46. Mutations that affect ligand binding to the E. coli aspartate receptor: implications for transmembrane signaling, Bjšrkman A.M., Dwarakanath, N.D., Dunten, P., Sandgren, M.O.J. and Sherry L. Mowbray, J. Biol. Chem. 276, 2808-2815 (2001).

 

47. Family 7 Cellobiohydrolases from Phanerochaete chrysosporium: Crystal structure of the catalytic module of CBH58 (Cel7D) at 1.32  resolution and homology models of the isozymes. Munoz, I.G., Ubhayasekera, W., Henriksson, H., Szabo, I., Pettersson, G., Johansson, G., Mowbray, S.L. and StŒhlberg, J. , J. Mol. Biol. 314, 1097-1111 (2001).

 

48. Structure and function of epoxide hydrolases. In 6th International ISSX Meeting. (ed. J.A. Hinson), pp. S29. Marcel Dekker, Inc., Munich. Arand, M., DŸrk, H., Hangen, N., Cronin, A., Oesch, F., Hallberg, M., Zou, J., Bergfors, T., Jones, T.A., and Mowbray, S.L. (2001).

 

49. Activation of ribokinase by monovalent cations. Andersson, C.E. and Mowbray, S.L. J. Mol. Biol. 315, 409-419 (2002).

 

50. Hinge-bending motion of D-allose binding protein from Escherichia coli: three open conformations. Magnusson, U., Chaudhuri, B.N.,  Ko, J., Park, C., Jones, T.A. and Mowbray, S.L. J. Biol. Chem. 277, 14077-14084 (2002).

 

51. An intron-containing family 9 cellulase gene encodes the dominant 90 kDa component of the cellulosome of the anaerobic fungus Piromyces sp. strain E2. Steenbakkers, P. J. M., Ubhayasekera, W., Goossen, H. J. A. M., van Lierop, E. M. H. M., van der Drift, C., Vogels, G. D., Mowbray, S. L. & Op den Camp, H. J. M. Biochem J. 365, 193-204 (2002).

 

52. Primary sequence determinants responsible for PDGF receptor site-selective dephosphorylation by the rPTP DEP‑1. Persson, C., Engstršm, U., Mowbray, S.L. and …stman, A. FEBS Lett 517, 27-31 (2002).

 

53. Structure of Escherichia coli ribose-5-phosphate isomerase: a ubiquitous enzyme of the pentose phosphate pathway and the Calvin cycle. Zhang, R.G., Andersson, C.E., Savchenko, A., Skarina, T. Evdokimova, E., Beasley, S. Arrowsmith, C.H., Edwards, A.M., Joachimiak A., and Mowbray, S.L. Structure, 11, 32-43 (2003).

 

54. A missense mutation in ftsZ differentially affects vegetative and developmentally controlled cell division in Streptomyces coelicolor A3(2). Grantcharova, N., Ubhayasekera, W., Mowbray, S. L., McCormick, J. R. & Flardh, K. Mol Microbiol 47, 645-656 (2003).

 

55. The N-terminal domain of mammalian soluble epoxide hydrolase is a phosphatase. Cronin, A., Mowbray, S., DŸrk, H., Homburg, S., Fleming, I., Fisslthaler, B., Oesch, F. and Arand, M. Proc Natl Acad Sci U S A 100, 1552-1557 (2003).

 

56. The catalytic module of Cel7D from Phanerochaete chrysosporium as a chiral selector: Structural studies of its complex with the -blocker (R)-propranolol. Mu–oz, I.G., Mowbray, S.L. and StŒhlberg, J., Acta Crystallogr D59, 637-643 (2003).

 

57. Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site. Arand, M., B. M. Hallberg, J. Zou, T. Bergfors, F. Oesch, M. J. van der Werf, J. A. M. de Bont, T. A. Jones and S. L. Mowbray EMBO J. 22, 2583-92 (2003).

 

58. The tell tale structures of epoxide hydrolases. Arand, M., Cronin, A., Oesch, F., Mowbray, S.L. and Jones, T. A. Drug Metabolism Reviews, 35, 365-83, (2003).

 

59. Cel6A, a major exoglucanase from the cellulosome of the anaerobic fungi Piromyces  sp. E2 and Piromyces equi Harhangi, H.R., Freelove, A.C. J., Ubhayasekera, W., van Dinther, M., Steenbakkers, P.J.M., Akhmanova, A., van der Drift, A., Jetten, M.S.M., Mowbray, S.L., Gilbert, H.J. and Op den Camp, H.J. M. Biochim. Biophys. Acta 1628, 30-39 (2003).

 

60. The 2.2  resolution structure of RpiB/AlsB from Escherichia coli illustrates a new approach to the ribose-5-phosphate isomerase reaction. Zhang, R.G., Andersson, C.E., Skarina, T., Evdokimova, E. Edwards, A.M., Joachimiak, A., Savchenko, A. and Mowbray, S.L. J. Mol. Biol. 332, 1083-94 (2003).

 

61. X-ray structures of the maltose-maltodextrin binding protein of the thermoacidophilic bacterium Alicyclobacillus acidocaldarius provide insight into acid stability of proteins. SchŠfer, K., Magnusson, U., Scheffel, F., Schiefner, A., Sandgren, M.O.J., Diederichs, K., Welte, W., HŸlsmann, A., Schneider, E. and Mowbray, S.L. J. Mol. Biol. 335, 261-274 (2004).

 

62. Mycobacterium tuberculosis ribose-5-phosphate isomerase has a known fold, but a novel active site. Roos, A.K., Andersson, C.E., Bergfors, T., Jacobsson, M., KarlŽn, A., Unge, T., Jones, T.A. and Mowbray, S.L. J. Mol. Biol. 335, 799-809 (2004).

 

63. X-ray structures of the leucine-binding protein illustrate conformational changes and the basis of ligand specificity. Magnusson, U., Salopek-Sondi, B., Luck, L. and Mowbray, S.L. J Biol Chem 279, 8747-8752 (2004).

 

64. Molecular cloning of a genomic DNA encoding yam class IV chitinase. Mitsunaga, T., Iwase, M., Ubhayasekera, W., Mowbray S.L. and Koga, D. Biosci. Biotechnol. Biochem. 68, 1508-1517 (2004).

 

65. X-ray structure of peptidyl-prolyl cis-trans isomerase A from Mycobacterium tuberculosis. Henriksson, L.M., Johansson, P., Unge, T. and Mowbray, S.L. Eur. J. Biochem. 271, 4107-4113 (2004).

 

66. Functional analysis of the chitin-binding domains and the catalytic domain of Brassica juncea chitinase BjCHI1. Tang, C.M., Chye, M.-L., Ramalingam, S., Shi-Wen, O., Zhao, K.-J., Ubhayasekera, W. and Mowbray, S.L. Plant Molecular Biology, 56, 285-298 (2004).

 

67. Competitive inhibitors of Mycobacterium tuberculosis ribose-5-phosphate isomerase B reveal new information about the reaction mechanism. Roos, A.K., Burgos, E., Ericsson, D.J., Salmon, L. and Mowbray, S.L. J. Biol. Chem. 280, 6416-6422 (2005).

 

68. Structures of Phanerochaete chrysosporium Cel7D in complex with product and inhibitors. Ubhayasekera, W. Mu–oz, I.G., Vasella, A., StŒhlberg J. and Mowbray, S.L FEBS J. 272, 1952-1964 (2005).

 

69. Structure and function of carbonic anhydrases from Mycobacterium tuberculosis. Covarrubias, A.S., Larsson, A.M., Hšgbom, M., Lindberg, J., Bergfors, T., Bjšrkelid, C., Mowbray, S.L., Unge, T. and Jones, T.A. J. Biol. Chem. 280, 18782–18789 (2005).

 

70. Synthesis of 5-deoxy-5-phospho-D-ribonohydroxamic acid: a new competitive and selective inhibitor of type B ribose-5-phosphate isomerase from Mycobacterium tuberculosis. Burgos, E., Roos, A.K., Mowbray, S.L. and Salmon, L. Tetrahedron Letters 46, 3691-3694 (2005).

 

71. Functional analysis of the glycero-manno-heptose 7‑phosphate kinase domain from the bifunctional HldE protein involved in the biosynthesis of ADP-D-glycero-D-manno-heptose. McArthur, F., Andersson, C.E., Loutet, S., Mowbray, S.L. and Valvano, M.A. J. Bacteriol. 187, 5292-5300 (2005).

 

72. Structure of Mycobacterium tuberculosis glutamine synthetase in complex with a transition-state mimic provides new functional insights. Krajewski, W.W., Jones, T.A. and Mowbray, S.L. PNAS 102, 10499-504 (2005).

 

73. Structure of an atypical epoxide hydrolase from Mycobacterium tuberculosis gives insights into its function. Johansson, P., Unge, T., Arand, M., Cronin, A., Bergfors, T., Jones, T.A. and Mowbray, S.L. J. Mol. Biol. 351, 1048-1056 (2005).

 

74. Characterization of an epoxide hydrolase from Mycobacterium tuberculosis functionally related to mammalian cholesterol epoxide hydrolase. Cronin, A., Adamska, M., Johansson, P., Bergfors, T., Jones, T.A., Mowbray, S., Richter, I., Unge, T. and Arand, M. BIOspektrum, 4, p. 433 (2005). (PreistrŠger)

 

75. 1.9  structure of deoxyxylulose 5-phosphate reductoisomerase from Mycobacterium tuberculosis. Henriksson L.M., Mowbray S.L., Unge T. Acta Crystallographica D,62, 807-813 (2006).

 

76. X-ray structure of potato epoxide hydrolase sheds light on substrate specificity. Mowbray, S. L., Elfstršm, L. T., Ahlgren, K. M., Andersson, C. E. and Widersten, M. Prot. Science 15, 1628-1637 (2006).

 

77. Structures of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase provide new insights into catalysis. Henriksson, L.M., Unge, T., Carlsson, J., qvist, J., Mowbray, S.L. and Jones, T.A. J Biol Chem 282, 19905-19916 (2007).

 

78. Crystal structures of a family 19 chitinase from Brassica juncea show flexibility of binding cleft loops. Ubhayasekera, W., Tang, C.M., Berglund, G., Bergfors, T., Chye, M.L. and Mowbray, S.L. FEBS J, 274, 3695–3703 (2007).

 

79. Microwave-enhanced alfa-arylation of a protected glycine in water. Evaluation of 3-phenylglycine derivatives as inhibitors of the tuberculosis enzyme, glutamine synthetase. Lagerlund, O., Odell, L.R., Mowbray, S.L., Nilsson, M., Krajewski, W.W., Nordqvist, A., KarlŽn, A. and Larhed, M.. Comb. Chem. High Throughput-Screen, 10, 783-789 (2007).

 

80. Involvement of loops in catalysis in family 19 chitinases. Ubhayasekera, W., Tang, C.M., Rawat, R., Ho, S.W.T., Chye, M.-L. and Mowbray, S.L. Adv. Chitin Sci. 10, 147-152 (2007).

 

81. X-ray structure of Candida antarctica lipase A shows a novel lid structure and a likely mode of interfacial activation. Ericsson, D.J., Kasrayan, A., Johansson, P., Bergfors, T., Sandstršm, A.G., BŠckvall, J.-E. and Mowbray, S.L. J. Mol. Biol. 376, 109-119 (2008).

 

82. Crystal structures of mammalian glutamine synthetases illustrate substrate-induced conformational changes, and provide opportunities for drug and herbicide design. Krajewski, W.W., Collins, R., Holmberg-Schiavone, L., Jones, T.A., Karlberg, T. and Mowbray, S.L. J. Mol. Biol. 375, 217-228 (2008).

 

83. Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery Nordqvist, A., Nilsson, M.T., Ršttger, S., Odell, L.R., Krajewski, W.W., Andersson, C.E., Larhed, M., Mowbray, S.L. and KarlŽn, A. Bioorg. Med. Chem., 16, 5501-13 (2008).

 

84. Removal of distal protein-water hydrogen bonds in a plant epoxide hydrolase increases catalytic turnover but decreases thermostability. Thomaeus, A., Naworyta, A., Mowbray, S.L. and Widersten, M. Protein Science 17, 1275-1284 (2008).

 

85. Structural, biochemical and in vivo investigations of the threonine synthase from Mycobacterium tuberculosis. Covarrubias, A.S., Hšgbom, M., Bergfors, T., Carroll, P., Mannerstedt, K., Oscarson, S., Parish, T., Jones, T.A. and Mowbray, S.L. J. Mol. Biol 381, 622-633 (2008).

 

86. Ribose 5-phosphate isomerase B from Escherichia coli is also a functional allose 6-phosphate isomerase while the same enzyme from Mycobacterium tuberculosis is not. Roos, A.K., Mariano, S., Kowalinski, E., Salmon, L., Mowbray, S.L. J. Mol. Biol. 382, 667-679 (2008).

 

87. X-ray structure of glucose/galactose receptor from Salmonella typhimurium in complex with the physiological ligand, (2R)-glyceryl-b-D-galactopyranoside. S. Sooriyaarachchi, W. Ubhayasekera, W. Boos, S.L. Mowbray, FEBS J. 276, 2116-2124 (2009).

 

88. Competitive inhibitors of type B ribose-5-phosphate isomerases: design, synthesis and kinetic evaluation of new D-allose and D-allulose 6-phosphate derivatives. Mariano, S., Roos, A.K., Mowbray, S.L. and Salmon, L. Carbohydrate Research 344, 869-880 (2009).

 

89. Directed evolution of an enantioselective epoxide hydrolase: Uncovering the source of enantioselectivity at each evolutionary stage. Reetz, M.R., Bocola, M. Wang, L.W., Sanchis, J, Cronin, A., Arand, M., Zou, J., Archelas, A., Bottalla, A.L., Naworyta, A. and Mowbray, S.L. J. Amer. Chem. Soc. 131, 7334-7343 (2009).

 

90. The first crystal structures of a family 19 class IV chitinase: the enzyme from Norway spruce. Ubhayasekera, W., Rawat, R., Ho, S.W.T., Wiweger, W., Von Arnold, S., Chye, M.L. and Mowbray, S.L. Plant Mol. Biol. 71, 277-289 (2009).

 

91. Structural basis of inhibition of Mycobacterium tuberculosis glutamine synthetase by novel ATP-competitive inhibitors. Nilsson, M.T., Krajewski, W.W., Yellagunda, S., Prabhumurthy, Srinivasa, B.R, Yahiaoui, S., Larhed, M., Jones, T.A. and Mowbray, S.L. J. Mol. Biol. 393, 504-513 (2009).

 

92. Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active b-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c. Carta, F., Maresca, A., Suarez Covarrubias, A., Mowbray, S.L., Jones, T.A. and Supuran, C.T. Bioorg. & Med. Chem. Lett. 19, 6649-6654 (2009).

 

93. Zinc ions bind to and inhibit activated protein C. Zhu, T., Ubhayasekera, W., Nickolaus, N., Sun, W., Tingsborg, S., Mowbray, S.L. and Schedin-Weiss, S. Thrombosis and Haemostasis, 104, 544-53 (2010).

 

94. Conformational changes and ligand recognition of Escherichia coli xylose binding protein revealed. Sooriyaarachchi, S., Ubhayasekera, W., Park, C. and Mowbray, S.L. J Mol Biol, 402, 657–668 (2010).

 

95. Structures of type B ribose 5-phosphate isomerase from Trypanosoma cruzi reveal the basis of sugar specificity in the structural family. Stern, A.L., Agata Naworyta, A., Cazzulo, J.J. and Mowbray, S.L., FEBS Journal, 278, 793-808 (2011).

 

96. Structural and functional studies of mycobacterial IspD enzymes. Bjorkelid, C., Bergfors, T., Henriksson, L.M., Stern, A.L., Unge, T., Mowbray, S.L. and Jones, T.A, Acta Crystallographica D67, 403-14 (2011).

 

97. Scots pine antimicrobial proteins act by binding b-glucan. Sooriyaarachchi, S., Jaber, E., Su‡rez Covarrubias, A., Ubhayasekera, W., Asiegbu, F.O. and Mowbray, S.L. Plant Molecular Biology 77, 33-45 (2011).

 

98. Design, synthesis and X-ray crystallographic studies of α-aryl substituted fosmidomycin analogues as inhibitors of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase. Andaloussi, M., Henriksson, L.M., Więckowska, A., Lindh, M., Bjšrkelid, C., Suarez Larsson. A.M., Iyer, H., Srinivasa, B.R, Bergfors, T., Unge, T., Mowbray, S.L., Larhed, M., Jones, T.A. and KarlŽn, A., J. Med. Chem. In press.

 

99. Synthesis of functionalized cinnamaldehyde derivatives by an oxidative Heck reaction and their use as starting materials for preparation of Mycobacterium tuberculosis 1-deoxy-D-xylulose-5-phosphate reductoisomerase inhibitors. Anneli Nordqvist,  Christofer Bjšrkelid,à Mounir Andaloussi,  Anna Jansson,à Sherry L. Mowbray, à Anders KarlŽn,  Mats Larhed, accepted J. Org. Chem.

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