Uppsala Software Factory - April Fools


Gullible, now, aren't we ?

For further enlightenment,
check today's date in your calendar ...

Take comfort in the fact that you are
dummy number
to check out this page (and counting ...)

Damn ! I want to talk to the manager of this outfit !

Have a look at this page as well !

Some of the almost 300 domains from which this page has been accessed are:
  1. 128.253.219.20
  2. 129.64.32.147
  3. 129.64.32.202
  4. 130.238.37.251
  5. 130.239.193.185
  6. 130.69.122.64
  7. 130.87.173.49
  8. 131.152.112.39
  9. 133.1.169.231
  10. 133.50.21.56
  11. 134.68.57.17
  12. 140.109.32.202
  13. 146.203.4.30
  14. 150.146.1.8
  15. 160.103.107.8
  16. 160.103.2.152
  17. 200.136.164.44
  18. 202.54.37.18
  19. 203.255.24.128
  20. 207.135.78.97
  21. acara.csb.ki.se
  22. acs1.wustl.edu
  23. adrenaline.berkeley.edu
  24. afmb72.cnrs-mrs.fr
  25. alf1.mrc-lmb.cam.ac.uk
  26. alf2.mrc-lmb.cam.ac.uk
  27. alice.bmc.uu.se
  28. xray.bmc.uu.se
  29. alpha8.bioc.cam.ac.uk
  30. alphy.roca.csic.es
  31. amino.usask.ca
  32. angel.niams.nih.gov
  33. apty.sci.hokudai.ac.jp
  34. asio.molbio.su.se
  35. aztec.chemistry.mcmaster.ca
  36. badbart.wustl.edu
  37. banquo.imb-jena.de
  38. basfegw2.basf-ag.de
  39. batman.depauw.edu
  40. bcl4.biochem.uga.edu
  41. bcl9.biochem.uga.edu
  42. bdvpc1.rug.ac.be
  43. berigw.beri.co.jp
  44. bernal.biochem.ubc.ca
  45. bigfoot.chem.upenn.edu
  46. billmo.biosci.arizona.edu
  47. bio14.chemie.uni-freiburg.de
  48. biocisis.unizh.ch
  49. biomaster.uio.no
  50. blagny.u-strasbg.fr
  51. bluejay.bioc.aecom.yu.edu
  52. bmbsgi15.leeds.ac.uk
  53. bmbsgi17.leeds.ac.uk
  54. boadicea.phys.unsw.edu.au
  55. bolan.bioc.le.ac.uk
  56. bonzai.crchul.ulaval.ca
  57. bossa-nova.cnb.uam.es
  58. bragg.bioz.unibas.ch
  59. bragg.bmb.psu.edu
  60. bragg.chem.cornell.edu
  61. bragg.ifqsc.sc.usp.br
  62. bravais.bri.nrc.ca
  63. bsmir14.biochem.ucl.ac.uk
  64. butthead.embl-hamburg.de
  65. cache1.serveurs-nationaux.jussieu.fr
  66. california.bio.purdue.edu
  67. calliope.swmed.edu
  68. camier.ibs.fr
  69. capri.biop.ox.ac.uk
  70. ccp4e.dl.ac.uk
  71. centris.bmc.uu.se
  72. chaucer.life.uiuc.edu
  73. chem-tdoukov.unl.edu
  74. chem28.colorado.edu
  75. chemac168.ucdavis.edu
  76. chex8.ex.ac.uk
  77. chop.swmed.edu
  78. chpc-jhn-3.st-and.ac.uk
  79. coconut028045.nuts.nwu.edu
  80. cookie.biop.umich.edu
  81. cpc.mel.dbe.csiro.au
  82. crash.wwwcache.ja.net
  83. cressida.imb-jena.de
  84. crissy.ucsf.edu
  85. crusty.lsb.sbs.auckland.ac.nz
  86. crystal.icgeb.trieste.it
  87. csc-a1592.mgh.harvard.edu
  88. d124b-labtop.stanford.edu
  89. dc-air.med.umn.edu
  90. dc-elf.med.umn.edu
  91. dialin-107.dialin.unibas.ch
  92. djinn-open.gene.com
  93. dorothy.ifqsc.sc.usp.br
  94. dynapro.cshl.org
  95. eagle.glasnet.ru
  96. echo.med.harvard.edu
  97. eden.bioc.cam.ac.uk
  98. eel.biochem.mpg.de
  99. elqana.saclay.cea.fr
  100. elroy.qci.bioch.bcm.tmc.edu
  101. eurogate.pfizer.co.uk
  102. f1n3.u.arizona.edu
  103. fedmac2.dl.ac.uk
  104. fermat.mc.duke.edu
  105. ff380.hh.ri.ccf.org
  106. firewall.esrf.fr
  107. ganymede.nrtg.com
  108. gate.ggr.co.uk
  109. gatekeeper.astra.com
  110. genie-open.gene.com
  111. glu.sb.fsu.edu
  112. glutamate.bio.cornell.edu
  113. glycine.bio.cornell.edu
  114. godot.ibs.fr
  115. gold.isbdd.vcu.edu
  116. green.niaid.nih.gov
  117. greenock-bank.clyde.net.uk
  118. groucho.med.jhmi.edu
  119. gutemine.uni-muenster.de
  120. h9bsd5054.aist-nara.ac.jp
  121. haemo.scripps.edu
  122. hasson.bio.purdue.edu
  123. hecate.rai.kcl.ac.uk
  124. helix.bchs.uh.edu
  125. hemebase.bio.uci.edu
  126. hermes.biomol.uci.edu
  127. hewes.icl.ox.ac.uk
  128. hg.pharm.nwu.edu
  129. hirta.bioc.cam.ac.uk
  130. hmt5.hitachi.co.jp
  131. host-207-53-9-204.rdu.bellsouth.net
  132. huldra.uninett.no
  133. idefix.ebi.ac.uk
  134. igate.ascc.net
  135. igw-se.pnu.com
  136. igw3.merck.com
  137. inca.chemistry.mcmaster.ca
  138. indigo1.bio.uci.edu
  139. indigo12.mc.vanderbilt.edu
  140. indy2.cryst.bbk.ac.uk
  141. infosun-fd.rus.uni-stuttgart.de
  142. interlock.pprd.abbott.com
  143. iris6.biochem.mcw.edu
  144. its-www1.massey.ac.nz
  145. jackdaw.embl-heidelberg.de
  146. jade.cmc.uab.edu
  147. jade.dfci.harvard.edu
  148. jake.embl-hamburg.de
  149. jeckle.med.harvard.edu
  150. jess.bath.ac.uk
  151. jinky.bioch.dundee.ac.uk
  152. jkindigo5.rockefeller.edu
  153. jm2310.livjm.ac.uk
  154. juliet.med.jhmi.edu
  155. jurancon.mbb.ki.se
  156. kakerlak.biochem.mpg.de
  157. kirti.cshl.org
  158. laue.bioz.unibas.ch
  159. lbmo2.ibs.fr
  160. lccphp1.ibs.fr
  161. leda.nagaokaut.ac.jp
  162. lithium.biophys.mpg.de
  163. lmb.biop.ox.ac.uk
  164. loyal.bch.ed.ac.uk
  165. lynx.chem.ou.edu
  166. macbeth.imb-jena.de
  167. mackinn-pc3.rockefeller.edu
  168. mailgate.celltech.co.uk
  169. malone.ibs.fr
  170. manu100.manu.com
  171. map-pc.nrl.navy.mil
  172. marin7.bc.ic.ac.uk
  173. marqusee9.berkeley.edu
  174. mars.esrf.fr
  175. mcb44.mcb.ucdavis.edu
  176. mcbi-46.med.nyu.edu
  177. mccgwy.m-kagaku.co.jp
  178. med-biop10.bu.edu
  179. med-biophg.bu.edu
  180. med-bragg.bu.edu
  181. metra.ucc.su.oz.au
  182. metro.ucc.su.oz.au
  183. milli.oci.utoronto.ca
  184. miro.biochem.nwu.edu
  185. moon.bmc.uu.se
  186. morse.scripps.edu
  187. msg-atgw.ucsf.edu
  188. msk-201-118.mskcc.org
  189. mush.cc.huji.ac.il
  190. nagg.ibs.fr
  191. neent.bmc.uu.se
  192. net186-81.its.yale.edu
  193. nikonov.ipr.serpukhov.su
  194. nob.pdb.bnl.gov
  195. ns.ibo.ch
  196. obi-wab.biochem.ualberta.ca
  197. opus.wistar.upenn.edu
  198. oskgate0.mei.co.jp
  199. oskgate2.mei.co.jp
  200. paia.ucsf.edu
  201. pandora.wi.mit.edu
  202. pc-young-d.chemistry.mcmaster.ca
  203. pcbdv2.rug.ac.be
  204. pec2.sc.ch.man.ac.uk
  205. pec4.sc.ch.man.ac.uk
  206. peggy-mac.nrl.navy.mil
  207. penguin.biophys.mpg.de
  208. pfizergate.pfizer.com
  209. phe.mpimf-heidelberg.mpg.de
  210. pierre.hh.ri.ccf.org
  211. pmate09.oci.utoronto.ca
  212. pohaku.lvl.pri.bms.com
  213. poppy.wwwcache.ja.net
  214. potto.bioch.virginia.edu
  215. prawn.biochem.mpg.de
  216. proxy.rediris.es
  217. quater.cryst.bbk.ac.uk
  218. quest.rose.brandeis.edu
  219. rab.oci.utoronto.ca
  220. rbo2.csb.yale.edu
  221. rburnett.wistar.upenn.edu
  222. rhino.cabm.rutgers.edu
  223. rogue.bchem.washington.edu
  224. romac3.niams.nih.gov
  225. rzinet.gbf-braunschweig.de
  226. sahara.dupontmerck.com
  227. salam.mbfys.lu.se
  228. sarek.bmc.uu.se
  229. sbsf-114.als.lbl.gov
  230. scpc8.rdg.ac.uk
  231. seal.csb.ki.se
  232. sgraf1.sc.ch.man.ac.uk
  233. shamrock.ebi.ac.uk
  234. shelx2.uni-ac.gwdg.de
  235. sherman.med.harvard.edu
  236. sherry.bmc.uu.se
  237. silver.niaid.nih.gov
  238. sissels.chem.uit.no
  239. skua.embl-heidelberg.de
  240. smac.ethz.ch
  241. solon.bmsc.washington.edu
  242. sp.spcorp.com
  243. srisvr.sri.org
  244. staffa.chem.gla.ac.uk
  245. striper.bioc.aecom.yu.edu
  246. t2o8p52.telia.com
  247. tau.mbb.ki.se
  248. thira.colorado.edu
  249. threonine.ucdavis.edu
  250. thymine.rutgers.edu
  251. tiger.bioch.virginia.edu
  252. tiger.cabm.rutgers.edu
  253. tigger.chem.york.ac.uk
  254. tome.cbs.univ-montp1.fr
  255. tpr.biop.ox.ac.uk
  256. troilus.imb-jena.de
  257. ucxray1.berkeley.edu
  258. ulti.niddk.nih.gov
  259. utbc08.cm.utexas.edu
  260. valine.bio.cornell.edu
  261. vcgate0.mei.co.jp
  262. vicious.bioc.le.ac.uk
  263. vidya.cshl.org
  264. vp2.med.harvard.edu
  265. vraptor.als.orst.edu
  266. walterlab-mac6.ucsf.edu
  267. www.bio.titech.ac.jp
  268. wwwproxy1.ac.il
  269. xanadu.tch.harvard.edu
  270. xgi6.cshl.org
  271. xmac6.ethz.ch
  272. xmmt020.avisnet.or.jp
  273. xray.rockefeller.edu
  274. xray.umdnj.edu
  275. xray0.princeton.edu
  276. xray1.ucmp.umu.se
  277. xrd2.isbdd.vcu.edu
  278. xserv1.dl.ac.uk
  279. xtal1.joslin.harvard.edu
  280. xtal10.tch.harvard.edu
  281. xtal200.harvard.edu
  282. zappa.extern.kun.nl
  283. zeelt.chem.ruu.nl
  284. zen.sb.fsu.edu
  285. zeta.embl-heidelberg.de
  286. zeus.compulink.gr
  287. zip.scripps.edu


What was this all about ?

Dear protein crystallographer !

The Uppsala Software Factory is proud to announce the release of a new program, called APRIL. APRIL stands for "Ab-initio Phasing using Rotationally Induced Likelihood". The program can be used to solve the phase problem in cases where you have two or more non-isomorphous crystal forms of the same (or related, e.g. mutants, complexes) compound.

The program exploits the inherent geometric redundancies (Bricogne, 1974) to extract phase information, after first solving the self-rotation (in case any of your crystal forms contain NCS) and cross-rotation functions. Trial phases are optimised using a maximum likelihood-based objective function.

Initial tests (using different lysozymes) have given excellent results, confirming previous models for the structure of this protein.

Now, I would like to invite you to become a beta-testing site in order to help optimise and debug the software.

Executables of APRIL (release 1) are available for SGI, OSF1, HP-UX, Solaris, Linux, and ZX-81. The program is CCP4-compatible. It requires at least two MTZ files as input (one for each crystal form), and some control information (e.g., number of molecules per asymmetric unit for each crystal form, resolution limits, etc.).

For more information about the program and downloading instructions, please point your browser to:

http://xray.bmc.uu.se/usf/april.html

or to:

http://xray.bmc.uu.se/usf/april.html

The beta version of APRIL will only be available today so as to limit the number of bonafide beta testers to a manageable number.

Happy phasing !

--Gerard Kleywegt
CEO, Uppsala Software Factory
("21st century software with a 19th century interface, but, hey, it's free !")


USF Latest update at 1 April, 1998.