SBNet

SBNet - Positions available


NOTE: if you want to announce a job opening, please use this form !


For jobs in crystallography check the lists of the IUCr, ACA, or BCA. The IUCr page also contains links to additional relevant sites. For jobs in NMR, look here or here. Some available postdoc and PhD positions can be found at www.FindAPostDoc.com and at www.FindAPhD.com. Various job opportunities can be found at the "Career Center" of the Science Advisory Board web site(here).


Note: positions in Scandinavia are shown on a coloured background.


PhD student position available

Date posted: 5 June, 2006

Deadline for applications: 21 June, 2006

Announcement will be removed: 22 June, 2006

Please find linked information on an open PhD-student position. The 
project is focusing on structural-functional investigations on 
beta-mannanases, a type of glycoside-hydrolases involved in plant 
cell-wall hydrolysis (in particular hemicelluloses). The project 
involves molecular biology, biochemistry and structural biology. 
Candidates shoulds have at least a Bachelor degree in 
Chemistry/Biology with Biochemistry.
The project start is planned to September 1st 2006 or according to agreement.


Aplication DEADLINE: JUNE 21st 2006 (its good to include reference persons).
Paper application marked "N B 21 297/2006" should be sent to:
REGISTRATOR, KANSLI N, LUND UNIVERSITY, Box118, 221 00, Lund, Sweden


Further information is available from:

Henrik Stålbrand, Associate professor
Biochemistry, Lund University
henrik.stalbrand@biokem.lu.se   Phone: +46-46-2228202

or according to the announcement.


Postdoctoral Position in Samsung Biomedical Research Institute

Date posted: 2 June, 2006

Deadline for applications: unknown

Announcement will be removed: 2 September, 2006

Postdoctoral Position - Protein Crystallography
Sungkyunkwan University School of Medicine
Samsung Biomedical Research Institute
Suwon, Korea

A post-doctoral position in protein crystallography is immediately available
at Sungkyunkwan University School of Medicine/Samsung Biomedical Research
institute in Suwon, Korea. The major project aims to solve the crystal
structure of several hydrolases from Thermococcus sp. In this project,
purified proteins will be provided for structure-determination. The second
project will focus on proteins involved in protein quality control and
ubiquitin processing. This projects will be complemented by functional
experiments using molecular biology and biochemistry, as well as alternative
biophysical techniques.  Hence, the applicant will be exposed to a variety
of disciplines.

The unit is newly equipped with automatic crystallization robot, X-ray
facility comprising a Rigaku rotating anode X-ray generator, R-Axis IV dual
imaging plate detector with confocal mirror optics, and X-stream
cryo-cooling system. Recent crystallographic studies in the lab also have
utilized synchrotron sources in Pohang Synchrotron Light Source (Korea), USA
(NSLS and ALS) and in Japan (spring-8 and Photon Factory). There are
excellent facilities for molecular biology, protein overexpression, and
biochemistry in the unit.

The applicant should have a PhD in crystallography, or a related research
area such as chemistry, biophysics, biochemistry or molecular biology.
However, experience in crystal structure determination is preferred.
Interested applicants please send a CV with the names of three references to
address below. E-mail inquiries about the position are welcome. Review of
applications begins June 10, 2006 and will continue until the position is
filled.

Kyeong Kyu Kim, Ph. D.
Department of Molecular Cell Biology
Samsung Biomedical Research Institute
Sungkyunkwan University School of Medicine
Suwon 440-746, Korea
tel : 82-31-299-6136
fax : 82-31-299-6159
e-mail : kkim@med.skku.ac.kr
web: http://smsb1.skku.ac.kr


PX positions available

Date posted: 2 June, 2006

Deadline for applications: unknown

Announcement will be removed: 2 September, 2006

PX positions with the Structural Genomics Consortium (SGC) in Toronto

The Protein Crystallography (PX) group of the Structural Genomics Consortium
(SGC) in Toronto is currently recruiting more crystallographers to extend
and expand core crystallographic expertise of the SGC:

 - Research Associate (1)
 - Postdoctoral Fellows (1)

For inquiries, please contact:
HR.sgc@utoronto.ca

alternatively, keep an eye on our jobs page
http://www.sgc.utoronto.ca/SGC-WebPages/toronto-employment.php
where some other positions are already advertised.

The SGC
===========
The Structural Genomics Consortium (SGC) is a not-for-profit organization
that aims to determine the three dimensional structures of proteins of
medical relevance, and place them in the public domain without restriction.
The SGC operates out of the Universities of Oxford and Toronto and
Karolinska Institutet, Stockholm. The Target List comprises proteins that
have relevance to human health and disease, such as proteins associated with
diabetes, cancer, and infectious diseases such as malaria. Research at the
SGC is divided into three areas: structural genomics of soluble proteins,
structural genomics of integral membrane proteins, and structural chemistry
of soluble proteins. SGC is jointly funded by the Wellcome Trust, a
consortium of Canadian and Swedish funding agencies, and GlaxoSmithKline,
and is one of the largest structural proteomics projects in the world.
Operations are split independently between the universities of Oxford,
Toronto and Karolinska Institutet but under overall leadership of Aled
Edwards, the Chief Executive.  The Toronto site is housed in the Banting
Institute, University of Toronto Faculty of Medicine, and coordinated by
Cheryl Arrowsmith, the Chief Scientist.

The SGC is adopting a biology-centered approach to structural genomics:
dedicated biology groups with target-specific expertise work on getting the
proteins soluble, and biophysical and functional characterizations feature
prominently.  The emphasis is decidedly on achieving high per-target success
rates rather than merely high target throughput.  Interesting biological
questions are further pursued either in-house or through collaborations.

The PX group
=============
Primary responsibility of the PX group, led by Alexey Bochkarev, goes from
assisting Biology groups in improving crystals to finalized structure, but
also pursuing follow-up structural studies into function and biology, in
close collaboration with the Biology groups of the SGC.  It will also
actively work in methodology development, specifically for improving
efficiency of SGC operations, but more generally according to the interests
of group members.

For more information see

http://www.sgc.utoronto.ca/SGC-WebPages/sgc-toronto.php

Alexey Bochkarev, Ph.D.
Principal Investigator, Structural Genomics Consortium
Associate Professor, Banting and Best Dept of Medical Research & Dept. of
Medical Genetic and Microbiology
University of Toronto
http://www.sgc.utoronto.ca/SGC-WebPages/alexey_bochkarev.php


bgcolor="CCCCCC">

Postdoctoral position available

Date posted: 2 June, 2006

Deadline for applications: unknown

Announcement will be removed: 2 September, 2006

Hauptman-Woodward Institute
Buffalo, New York

A NIH funded post-doctoral opportunity exists for a highly motivated
individual in the Laboratory of Dr. Michael Malkowski at the
Hauptman-Woodward Medical Research Institute.  The HWI houses the Center for
High-Throughput Structural Biology (CHTSB), one of six specialized centers
funded by the NIH Protein Structure Initiative tasked with developing
innovative methods and technologies to facilitate the structural
characterization of proteins traditionally difficult to study.  The research
conducted in our Laboratory and within the CHTSB focuses on the structural
and functional characterization of membrane proteins, particularly those
involved in lipid metabolism.  Applicants should have a Ph.D. in
Biochemistry, Molecular Biology, or related field, with a strong background
in molecular biological techniques, protein expression and purification, and
functional characterization of proteins.  Previous experience in working
with membrane proteins and/or in the field of x-ray crystallography, while
not required, is a plus.

The HWI is an independent non-profit research Institute that also serves as
the Structural Biology Department at the University at Buffalo.  The
Institute is part of the Buffalo-Niagara Medical Campus in downtown Buffalo.
We have just moved into a new facility, which can be viewed at
http://www.hwi.buffalo.edu.  The HWI has a long history in methods
development and structure determination through X-ray crystallography and an
offers an outstanding collegial environment.

Interested candidates should send a CV and cover letter to:

Michael G. Malkowski, Ph.D.
Research Scientist
Hauptman-Woodward Medical Research Institute
700 Ellicott Street
Buffalo, New York  14203-1102

Phone:  (716) 898-8624
Email:  malkowski@hwi.buffalo.edu
Web:  http://www.hwi.buffalo.edu


Postdoctoral position available

Date posted: 2 June, 2006

Deadline for applications: unknown

Announcement will be removed: 2 September, 2006

The newly established research group of Thilo Stehle at the University
of Tübingen is looking for a Post-Doc. The major focus of our research
is to define molecular mechanisms of attachment and cell entry for
viruses and other pathogens. We use protein crystallography in
conjunction with other biophysical techniques and functional assays to
elucidate principles of interactions between pathogens and host cell
receptors.

The ultimate objectives of these studies are (1) to understand the
features that are used by pathogens for docking to the cell, (2) to
correlate differences in disease with structural differences between
pathogens, (3) to  contribute to our under-standing of pathogen
evolution, and (4) to develop strategies that can lead to productive
interference with the attachment process (i.e. drug design).  We are
looking for highly motivated individuals with a background in
biochemistry, molecular biology, or virology to join our expanding
research team. Experience in structural biology will certainly be
beneficial. Our group has recently moved from Harvard Medical School
in Boston to Tübingen, and we occupy a newly equipped laboratory with
state-of-the-art facilities within the Interfacultary Institute for
Biochemistry. The available position is funded through SFB grants from
the DFG. More information about the laboratory and specific projects,
including publications, can be found on our website:

http://www.ifib.uni-tuebingen.de/Stehle/

For further information please contact:

Prof. Dr. Thilo Stehle
Interfakultäres Institut fü Biochemie
Universität Tübingen
Hoppe-Seyler-Str. 4
72076 Tübingen
+49-7071-2973043
thilo.stehle@uni-tuebingen.de


Postdoctoral position available

Date posted: 2 June, 2006

Deadline for applications: unknown

Announcement will be removed: 2 September, 2006

University of Minnesota Medical School, Twin Cities

Postdoctoral Position in Macromolecular Crystallograohy is available immediately in the 
laboratories of Karen H. Ashe, Ph.D. (Department of Neurology; http://www.neurology.umn.edu/neurology/faculty/hsiaoashe/home.html) 
and Carrie M. Wilmot, Ph.D. (Department of Biochemistry, Molecular Biology & Biophysics; 
http://biosci.cbs.umn.edu/BMBB/faculty/Wilmot.C.html) to determine the X-ray crystal 
structures of molecular assemblies linked to the progression of Alzheimer's disease 
(Lesne et al. (2006) Nature 440, 352-7). The candidate must possess a Ph.D. in 
biochemistry, chemical biology or biophysics, and demonstrate a strong commitment to 
macromolecular crystallography. Candidates with a rigorous background in protein 
purification from source material, particularly involving antibody affinity 
chromatography, and expertise in crystallization, are encouraged to apply. Send 
curriculum vitae, and the names of at least two referees, to Dr. Wilmot, e-mail: wilmo004@umn.edu.

Superb facilities are available for x-ray data collection (http://cbs.umn.edu/bmbb/structbio/facilities/crystallography.html, http://www.mbc-als.org/) and for computation 
(http://www.msi.umn.edu/bscl/). The University of Minnesota is very highly rated among 
American Public Research Universities (http://thecenter.ufl.edu/research2003.html). 
Biological sciences and the Medical School continue to expand at the University of 
Minnesota with a number of new buildings opened during the last five years. In addition, 
the Twin Cities are a focus for the performing arts and Minnesota offers a broad spectrum 
of outdoor activities during all seasons.

The University of Minnesota is an Equal Opportunity Educator and Employer.

If you have any questions or require further information, please contact 
Carrie Wilmot
wilmo004@umn.edu
Assistant Professor & Director of the Kahlert Structural Biology Lab,
Department of Biochemistry, Molecular Biology & Biophysics,
Twin Cities Campus, University of Minnesota.

Mailing address:
Department of Biochemistry, Molecular Biology & Biophysics,
6-155 Jackson Hall, 321 Church St SE,
Minneapolis, MN 55455-0215, USA.

Office:                                                 Lab:
5-120 Nils Hasselmo Hall,                5-230 Nils Hasselmo Hall,
312 Church St SE.                             312 Church St SE.
Tel: +1-612-624-2406                        Tel: +1-612-624-0141
Fax: +1-612-624-5121
WWW: http://biosci.cbs.umn.edu/BMBB/faculty/Wilmot.C.html


Protein Crystallographer Position (Post-Doc)

Date posted: 2 June, 2006

Deadline for applications: unknown

Announcement will be removed: 2 September, 2006

A position for a crystallographer at the post-doc level is available in Dr. Kirill 
Alexandrov’s research group at the Max-Planck-Institute for Molecular Physiology 
(Dortmund, Germany). The lab is focused on the development of new approaches for the 
production and biophysical analysis of posttranslationally modified proteins and 
multiprotein complexes. As the primary model system we use the molecular machinery 
regulating intracellular vesicular traffic with an emphasis on RabGTPase interacting and 
modifying proteins. The laboratory closely collaborates with the chemistry department 
at the same institute and the industry on several projects. Details of ongoing research 
and recent publications can be found under http://www.mpi-dortmund.mpg.de/departments/dep3/alexandr_rak/01/01.html .

We are seeking a PhD graduate to determine the crystal structures of several important 
protein complexes. Candidates should have experience in crystal structure determination 
as well as an interest in the biophysics of protein:protein interaction. The position 
provides an outstanding training program in protein biochemistry, structure and molecular 
biology in a generously funded, dynamic, and team-oriented research program.

The MPI has outstanding facilities for molecular biology; protein expression, purification, 
and biochemistry; and protein crystallography. The department of Physical Biochemistry has 
large expertise in analysis of biomolecular interactions using fluorescent spectroscopy 
and other major biophysical methods. The candidate is expected to benefit form the 
automated high-throughput protein production platform that is being established as a part 
of Systems Biology initiative at the MPI. Computer and hardware support are provided by 
core facilities and by a group leader level X-ray specialist.

The position is available for 2 years initially. Housing and other living expenses in 
Dortmund are very reasonable.

Please send your CV, a summary of research experience and interests, and names, addresses, 
e-mail and telephone numbers of 3 references to the address given below. E-mail 
applications will be preferred.

PLEASE PUT : “ Application for Protein Crystallographer position ” into the subject line.


Dr. Kirill Alexandrov
Labartory of molecular mechanisms of vesicular transport
Department of Physical Biochemistry
Max-Planck-Institute for Molecular Physiology
Otto-Hahn-Strasse 11
44227 Dortmund
Germany

E-mail: kirill.alexandrov@mpi-dortmund.mpg.de
Phone: -49-231-1332356
Fax: -49-231-1331651


Postdoctoral position available

Date posted: 25 May, 2006

Deadline for applications: unknown

Announcement will be removed: 25 August, 2006

Applications are invited for a postdoctoral position in Dr. Fang Li's
lab at the Department of Pharmacology, University of Minnesota Twin
Cities. Research involves biochemical and structural studies on
proteins that guide invasion and replication of SARS, Avian Influenza,
and Ebola viruses.

Strong background in molecular biology and protein biochemistry is
required. Experience in eukaryotic cell culture is preferred.
Candidates must have completed PhD at the time of the appointment.
Salary commensurates with experience. The position starts from early
2007. For more information about Dr. Li's lab, visit
http://crystal.harvard.edu/lifang

Interested applicants should send (1) a resume, (2) a one-page summary
of previous research experience, (3) a one-page description of
current/future research interest, and (4) arrange three letters of
recommendation to Dr. Fang Li via email:
lifang@crystal.harvard.edu


Postdoctoral position in protein crystallography in Sydney, Australia

Date posted: 25 May, 2006

Deadline for applications: unknown

Announcement will be removed: 25 August, 2006

Postdoctoral position in protein crystallography

A postdoctoral position is available in the Protein Structure Group at
the University of New South Wales, Sydney, Australia.  The project is a
collaboration with CBio Ltd, an Australian biotech company focusing on
proteins involved in inflammation control. The candidate should have a
strong background in protein crystallisation and structure determination.

The postdoc will be based at UNSW where we have in house facilities for
protein expression, purification and characterisation (although protein
will generally be supplied by CBio). Data collection facilities include
a rotating anode generator equipped with a MAR34 detector, Osmic mirrors
and Oxford cryo system. We have regular access to synchrotron sources.
We expect to install state-of-the-art robotic systems for
crystallisation shortly.


The position will be offered initially for one year with the possibility
of renewal.

For further information contact (preferably by email):

Paul Curmi
School of Physics, University of New South Wales
Sydney UNSW 2052, 
Australia
Email   p.curmi@unsw.edu.au
URL: www.phys.unsw.edu.au/ibis/index.html


Postdoctoral position available

Date posted: 19 May, 2006

Deadline for applications: 8 June, 2006

Announcement will be removed: 9 June, 2006

Postdoctoral Research Fellowship (Postdoktor) in Protein Crystallography

available at the Department of Chemistry, University of Oslo.

For further information please contact: 
Assoc. Professor Ute Krengel, 
ph. +47 22 85 54 61, e-mail:ute.krengel@kjemi.uio.no

Pay grade 53-56, depending on qualifications (corresponding to ca. 30-32 KNOK)

The position is available immediately for a period of three years.

Deadline for applications: June 8, 2006

REF. NO. 06/6591/AQU

The application should include a CV (including in particular any experience relevant to 
the position announced) as well as the names and contact details of three references, 
together with a cover letter stating why the applicant has a special interest in this 
position. Applicants should also submit a list of published and unpublished works and 
certified copies of certificates/diplomas. The application should include copies of the 
applicants’ five most significant publications and a summary of the importance of these 
works. For more information see:
http://www.uio.no/admhb/reglhb/personal/tilsettingvitenskapelig/guidelinespostdoctor.xml

Applications (marked with Ref. No. 06/6591/AQU) must be sent to The Faculty of Mathematics and 
Natural Sciences, P. O. Box 1032 Blindern, NO-0315 Oslo, Norway.

The cover letter and CV may be submitted by e-mail to a.h.quande@matnat.uio.no, 
whereas all supporting documentation must be submitted by regular mail.

Application papers will not be returned, with the exception of original publications.

A postdoctoral research fellowship (financed by the Norwegian Research Council, project title 
"Structural Glycobiology") is available at the Department of Chemistry, The Faculty of 
Mathematics and Natural Sciences, University of Oslo, in the group of Associate Professor Dr. 
Ute Krengel. Preferred starting date is this fall (September 1st or soon thereafter).

The postdoctoral project will be in the field of protein crystallography, targeting human mucins. Mucins are the major glycoprotein components that confer the mucous its viscous gel-like properties. 
By covering the digestive, respiratory and urogenital 


Protein Crystallographer (with Ph.D)

Date posted: 19 May, 2006

Deadline for applications: unknown

Announcement will be removed: 19 August, 2006

PROTEROS is the leading service-provider for the preparation and
three-dimensional structural analysis of proteins for the
structure-guided drug design. Our work contributes to the fast and
rational drug development. Since its foundation in 1998, Proteros is a
continually growing, respected enterprise and collaborates with many
international pharmaceutical, crop science and biotechnology companies.
Proteros is located in Martinsried, near Munic, Germany.



To support our existing crystallography team we are looking for a

Protein Crystallographer (with Ph.D)

for:
  • planing and accomplishment of crystallisation experiments of proteins,
  • analysis and evaluation of protein crystals and diffraction patterns,
  • evaluation of diffraction data,
  • data collection at synchrotron beamlines
  • further development of new methods and Work-flow optimisation
  • protein crystal-structure solving, modelling, and refinement Requirements:
  • PhD in chemistry , biology, or pharmacy. with excellent records
  • knowledge and experience with protein crystallisation
  • knowledge and experience with protein structure determination
  • knowledge of PC's including Unix/Linux systems You are proactive and able to work under strict time lines. Additionally, you have excellent communictaion skills and like to work in an interdisciplinary team. Industry experience is an asset. Please apply by sending your full application documents to jobs@proteros.de or to Karin Grennrich Am Klopferspitz 19 82152 Martinsried Germany <<<<<<<<<<<<<<<<<<<<<<<<<<<< Link: http://www.bio-m.de/upload/job/1915/datei/WM%20PXX_01_060510.pdf

  • Protein crystallographer position available

    Date posted: 19 May, 2006

    Deadline for applications: 6 June, 2006

    Announcement will be removed: 7 June, 2006, 2006

    Protein Crystallographer - AstraZeneca,Mölndal
    
    AstraZeneca is now looking for a PhD with hands on experience of protein
    crystallography. This one year temporary position will be placed in the
    crystallography group at the Structural Chemistry Laboratory at AstraZeneca
    R&D Mölndal, Sweden.
    
    The Structural Chemistry Laboratory, Mölndal is a centre of excellence
    supporting the AstraZeneca discovery organizations in Sweden, UK and US.
    The laboratory has around 35 scientists engaged in experimental research and
    the core disciplines are protein engineering, NMR spectroscopy and protein
    crystallography. The lab is excellently equipped with state of the art
    equipment. Recently a full set of robotics has been installed to support the
    process from protein crystallization to data collection.
    
    The successful candidate will join one of the sub-teams and work in direct
    support of one of the therapeutic areas. This is an excellent opportunity
    for a structural scientist to gain experience from the international and
    multidisciplinary environment within one of the worlds leading
    pharmaceutical companies.
    
    The candidate will mainly be involved in the support of structure-based
    drug-design projects. The candidate should therefore have a strong genuine
    interest in and experience from studying molecular interactions by
    crystallography preferentially in a pharmaceutical environment. Experience
    from synchrotron and computational work and an organized working-practice
    are strictly necessary requirements. A background in organic chemistry,
    biochemistry or biophysics is advantageous.
    
    The position requires enthusiasm, flexibility and a natural talent to
    interact in a team as well as the ability to communicate effectively.
    
    For additional information, please contact 
    Helena Käck AstraZeneca, +46 708 467091, email:helena.kack@astrazeneca.com
    
    Please send your application and CV marked "71-11546 Protein
    Crystallographer" no later than June 6, 2006 via www.astrazeneca.com 
    We will only consider applications received via our website.
    
    Link to the position: http://www.astrazeneca.se/vp/hr/show_vacant.asp?ItId=7381
    


    Postdoctoral position available

    Date posted: 19 May, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 August, 2006

    Postdoctoral position ˆ Auckland, New Zealand
    
    Structural biology of insect olfactory proteins
    
    A three-year postdoctoral position is available at HortResearch (Auckland, New
    Zealand), in the area of protein structure determination by X-ray
    crystallography. The project focuses on the structural and functional biology
    of proteins involved in olfaction in insects and will be carried out in
    collaboration with Professor Ted Baker at the School of Biological Sciences,
    University of Auckland.  Odorant binding proteins and other proteins involved
    in insect communication will be over-expressed for crystallisation and their
    structures solved by X-ray analysis.  Ligand binding will also be investigated
    through biochemical binding assays.  The ultimate goal of the project is to
    identify novel protein structures that can be used to develop new insect
    control strategies by structure-aided design.
    
    
    For further information please contact
    
    Dr Richard Newcomb
    Molecular Olfaction
    HortResearch
    Private Bag 92169
    Auckland, New Zealand
    Email:  rnewcomb@hortresearch.co.nz
    
    or
    
    Professor Ted Baker
    School of Biological Sciences
    University of Auckland
    Private Bag 92019
    Auckland, New Zealand
    Email: ted.baker@auckland.ac.nz
    


    Ph.D. Position available at the Paul Scherrer Institut

    Date posted: 19 May, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 August, 2006

    The Paul Scherrer Institut is a centre for multi-disciplinary research and one of the world’s leading user
    laboratories. With its 1200 employees it belongs as an autonomous institution to the Swiss ETH domain and 
    concentrates its activities on solid-state research and material sciences, elementary particle and astrophysics, 
    energy and environmental research as well as on biology and medicine.
    
    We are looking for a
    
     PhD Student in Molecular Biology/Biochemistry/Structural Biology
    
    *Your tasks*
    
    Our group investigates the structure/function relationship of cell surface receptor interactions in neuronal 
    guidance, angiogenesis and cell adhesion, with implications to cancer development. You will be involved in cloning, 
    expression, and purification of target sequences and in the characterization of the resulting materials by 
    biochemical and biophysical methods, including X-ray crystallography. The project is carried out within the 
    structural biology group at PSI, which offers excellent facilities for molecular biology and structural research 
    at its synchrotron, the Swiss Light Source. For further information on our projects, see http://sb.web.psi.ch.
    
    *Your profile*
    
    You hold a Diploma/Masters or equivalent degree preferably in Biophysics, Biochemistry, or Molecular Biology. 
    Crystallographic training is not an absolute requirement, but a plus. Practical skills in Molecular Biology and 
    Protein Chemistry are highly desirable and proficiency in written and oral communication in English is required. 
    Being a self-motivated, organized, creative, and enthusiastic team player is essential to ensure your success in 
    completing your Ph.D. in this exciting, dynamic and extensively growing field of research.
    
    The thesis will be carried out as a graduate student of the Department of Biology at ETH Zurich, which offers an 
    excellent graduate students program (for further information, see http://www.mol.biol.ethz.ch/).
    
    *We are looking forward to your application.*
    
    For further information please contact Dr. A. Prota, Tel. +41 56 310 5160,
    e-Mail: andrea.prota@psi.ch
    
    Please send your application to: Paul Scherrer Institut, Human Resources,
    Mrs. Hedwig Habersaat, ref. code 2311-01, 5232 Villigen PSI, Switzerland.
    
    


    Scientist-level structural biology position

    Date posted: 19 May, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 August, 2006

    Scientist-level structural biology position at Takeda San Diego
    Takeda San Diego, Inc.
    
    Website: http://takedasd.com/career/detail.php?keyID=119&department_name=Structural+Biology
    
    Scientist-- Structural Biology
    San Diego
    Jobcode 210-SciCB-0506
    Job Description:
    
    "Qualifications:
    
  • "At least 3 years of industrial experience, or the equivalent, on the purification, biophysical characterization, modification, crystallization of challenging eukaryotic proteins, including membrane associated proteins.
  • "Ph.D or equivalent in experience required.
  • "Experience in protein crystallization and protein small molecule complex structure determination, including the use of common software packages for these purposes.
  • "Experience using a wide variety of protein purification techniques, including affinity and classical purification methods to produce active, highly purified and concentrated proteins
  • "Ability to work as an independent researcher in a high-throughput protein production and purification environment, working with a number of different samples in parallel while maintaining sample integrity
  • "Interest in learning and developing new protein purification, modification, and analytical skills
  • "Excellent organization, communication, and record-keeping skills
  • "Some familiarity with signaling pathways associated with cancer or metabolic disease "Job Responsibilities:
  • "Conduct independent protein purification projects, including challenging targets such as membrane proteins
  • "Characterize eukaryotic proteins by spectrophotometric and chromatographic methods and improve chances of success in crystallization by modification and/or extra purification
  • "Conduct milligram scale purifications of target proteins, and deliver active proteins at very high levels of purity and concentration
  • "Grow crystals of target proteins and solve structures from the collected x-ray data sets
  • "Work with other group members to improve current processes and workflows, and look for ways to improve output within the department
  • "Maintain accurate lab records, and enter those records into the Company systems in a timely manner
  • "Participate in intra-company drug discovery teams and provide leadership to team members involved in protein purification and analysis How to apply Please note all inquiries with job code. Mail resumes to: Takeda San Diego Attn: Human Resources 10410 Science Center Drive San Diego, CA 92121 E-mail: HR@takedasd.com Takeda is an equal opportunity employer.

  • Postdoctoral position available

    Date posted: 11 May, 2006

    Deadline for applications: unknown

    Announcement will be removed: 11 August, 2006

    Postdoctoral Position in Structural Biology, Imperial College London
    
    Antibiotic resistance is a widely used phenomenon
    in bacteria and is becoming a health problem
    worldwide. One of the major mechanisms underlying
    multidrug resistance in both prokaryotes and
    eukaryotes is the active extrusion of numerous
    structurally unrelated toxic compounds by
    membrane proteins known as multidrug-efflux
    transporters. Several transcription regulators
    have been demonstrated to promote transporter
    expression in response to structurally dissimilar
    toxic compounds. Therefore the elucidation of the
    regulator proteins offers alternative avenues for
    understanding the mechanism of bacterial
    multidrug resistance and potential antimicrobials
    and novel drug development. This project aims to
    characterise structurally the set of regulators
    that control the efflux pumps in the best
    characterised P.putida DOT-T1E strain. P.Putida
    has the unusual property of tolerating high
    concentration of toxic compounds including
    antibiotics, plant secondary metabolites and
    organic solvents and is a close relative to P.
    Florescens and P. Aeruginosa, the latter being
    highly pathogenic to humans and animals. The
    structural information obtained and mechanisms
    derived should help us understand how P.Putida
    and other bacteria achieve multidrug and solvent
    resistance and provide avenues for future
    antimicrobials and drug design.
    
    This position is available immediately for 3
    years on the Research and Education Family, Level
    B, with a starting salary in the range of £26,120
    - £33,330 depending on experience. The successful
    candidate should hold a PhD in structural
    biology, biochemistry or a related area with
    proven experience in structural biology. You will
    be joining a dynamic, international,
    multidisciplinary research group located within
    the South Kensington campus. For initial
    enquiries please contact Dr Xiaodong Zhang
    (xiaodong.zhang@imperial.ac.uk, +44 (0) 20 7594
    3151, www.msf.bio.ic.ac.uk)
    
    


    Membrane protein crystallographer

    Date posted: 9 May, 2006

    Deadline for applications: 12 June, 2006

    Announcement will be removed: 13 June, 2006

    Stockholm University
    Center for Biomembrane Research
    
    The new Center for Biomembrane Research (CBR) at Stockholm University is funded
    by a grant from the Swedish Foundation for Strategic Research and is administered by
    the Department of Biochemistry and Biophysics (DBB). CBR is headed by Prof.
    Gunnar von Heijne.
    
    DBB is now inviting applications for a position as researcher in membrane protein
    crystallography at CBR.
    The appointment is for 6 years, with a possible 2 year extension contingent upon the
    outcome of an evaluation of scientific and leadership skills made by DBB during the
    fifth year.
    Priority will be given to applicants holding a PhD no older than 5 years. Evaluation of
    the candidates will be based on scientific merits and potential, as well as demonstrated
    skills in leadership and scientific collaborations.
    
    For further information about the position and about CBR, please contact Prof. Gunnar
    von Heijne (gunnar@dbb.su.se) or check the CBR homepage (www.cbr.su.se).
    The application should include the following items:
    
    1. Curriculum vitae
    2. A numbered bibliography
    3. A description of the candidate’s research achievements, scientific collaborations, leadership abilities, and research plans for the next 3 years (maximum 5 pages).
    4. PDF files of the 10 most important research publications of the candidate’s own choice.
    The application (in a single PDF file) and the 10 publications should be sent as e-mail attachments to registrator@su.se, and should arrive by June 12, 2006. Please mark the application with the registration number Dnr 619-1032-06. A signed application should also be sent to Stockholm University, Registrar/PA, SE-106 91 Stockholm, Sweden. Trade union representatives that may be contacted are Bo Ekengren (SACO), Lisbeth Häggberg (ST), and Birgitta Carlén (SEKO), phone (switchboard) +46-8-162000.


    Postdoctoral Fellow Research Scientist

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    Medical Structural Genomics of Pathogenic Protozoa
    Biomolecular Structure Center
    University of Washington, Seattle
    
    The MSGPP project at the University of Washington is a collaborative
    effort involving medical researchers, synthetic and computational
    chemists, and crystallographers.  Our overall goal is to identify
    and exploit potential drug targets drawn from the genomes of eukaryotic
    pathogens such as Plasmodia, Trypanosoma, Entamoeba, Giardia,
    Cryptosporidia, and Leishmania.
    
    We have immediate openings for postdoctoral fellows and research
    scientists to participate as crystallographers. The focus of their
    efforts will be
    
    
  • initial structure determination of selected target proteins
  • identification of potential starting points for drug design based on known inhibitors of homologous proteins
  • identification of potential starting points for drug design based on crystallographic screening of cocktails (mixtures) of chemically distinct fragments
  • collaboration with synthetic and computational chemists to exploit crystallographically identified binding interactions Experience with a range of structure determination methods is a plus, although SeMet MAD phasing is the primary method planned for initial structure determinations. Prior experience with crystallographic computing is essential. Please send CV, list of publications, a description of research interests and experience, plus a list of three references by Email to Ethan Merritt Biomolecular Structure Center Department of Biochemistry University of Washington Seattle, WA 91895-7742 USA

  • Postdoctoral position available

    Date posted: 9 May, 2006

    Deadline for applications: unknown

    Announcement will be removed: 9 August, 2006

    A 2-3 year Australian Research Council-funded post-doctoral research position is 
    available immediately with Drs Peter Lewis and Renate Griffith in the School of 
    Environmental and Life Sciences, University of Newcastle, New South Wales, Australia.
    
    The post-holder will investigate a number of RNA polymerase complexes from the model Gram 
    positive bacterium /Bacillus subtilis/ using both cryo-electron microscopy and X-ray 
    crystallography, in conjunction with Dr Ben Hankamer at the University of Queensland 
    (http://www.imb.uq.edu.au/), Australia, and Dr Rick Lewis University of Newcastle, UK 
    (http://www.ncl.ac.uk/camb/), respectively. RNA polymerase is a target for the design of 
    anti-microbials and the structures obtained during the course of the research proposal 
    will serve as templates for the design and synthesis (in collaboration with local 
    colleagues) and the validation by biochemical and structural analyses of novel 
    anti-microbials. Prior experience in cryo-electron microscopy and single particle 
    analysis and/or X-ray structure determination of large assemblies is highly desirable.
    
    It will be necessary for the post-holder to make several trips to Brisbane, for the EM 
    studies, whilst also participating in an exchange programme with colleagues in Newcastle, 
    UK on aspects of the crystallography.
    
    Salary starting: A$55452-62657 dependent on experience (June 2006 rates).
    
    Newcastle (Australia), a coastal city famous for its surfing beaches, is about 2 hours 
    drive north of Sydney, and is well connected to all other major Australian cities by air. 
    It is situated at the mouth of the Hunter river, and is adjacent to the Hunter Valley, a 
    famous wine-growing region, in addition to many other costal and bush locations of 
    outstanding natural beauty. Newcastle enjoys a very pleasant climate all year round.
    
    Applicants should submit a covering letter, CV and details of three referees directly to 
    Dr Peter Lewis: Peter.Lewis@newcastle.edu.au, from whom further information can also be 
    obtained.
    


    Postdoctoral Research Positions in Bioinformatics

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    Applications are invited for a postdoctoral Research Associate positions in the lab of Prof. 
    Dennis R. Livesay, starting approximately August 2006. A current challenge of bioinformatics 
    is to be able to predict protein functional sites from sequence and structure. This project 
    builds upon prior success of phylogenetic motifs (PMs) to identify functional regions from 
    sequence. PMs are alignment fragments that mirror the overall familial phylogeny (see La et al., 
    Proteins, 2005 and La & Livesay, BMC Bioinformatics, 2005). One of the primary goals of this 
    project is to extend the PM approach to identify specific catalytic sites (versus functional 
    site regions) using a neural network and/or machine learning approach. Also, the successful 
    candidate will be expected to learn and apply a wide variety of other state-of-the-art functional 
    site prediction techniques, including: evolutionary trace, ConSurf, topology-based approaches, 
    strain energy-based approaches, etc.
    
    Candidates should be highly motivated with a Ph.D. in Bioinformatics, Biology, Computer Science 
    or related discipline. Candidates should have prior experience in the area of Bioinformatics 
    and/or Computational Biophysics with a demonstrated ability to conduct research independently. 
    Demonstrated knowledge of basic sequence and structure analysis techniques is required. Candidates 
    are also expected to have strong programming skills. Knowledge of UNIX/LINUX operating systems 
    is essential; prior experience with grid/cluster computing is preferred, but not absolutely required. 
    Prior experience with database design, MySQL and CGI programming is also preferred.
    
    More information can be obtained at http://www.csupomona.edu/~drlivesay. Note that starting in August, 
    Prof. Livesay will be moving his lab to the Bioinformatics Research Center at the University of North 
    Carolina at Charlotte, which is where the successful candidate will be employed. Applicants interested 
    in applying should send curriculum vitae and graduate transcripts (a copy is okay) to Prof. Dennis R. 
    Livesay, Dept. of Chemistry, Cal Poly Pomona, 3801 W. Temple Ave, Pomona, CA 91768 or electronically 
    to drlivesay@csupomona.edu. Applicants should also arrange for three letters of reference to be sent 
    to the same address; applicants should not send reference letters themselves. Full consideration will 
    be to applications received before June 1, 2006. UNC-Charlotte is an EOE/AA employer.
    
    http://www.csupomona.edu/~drlivesay
    


    Postdoctoral position at Biozentrum (Basel)

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    "Molecular structural biology for nano-material development"
    
    This interdisciplinary project aims at the design and production of protein building blocks for the 
    development of nano-objects.
    
    The candidate will be in charge of the molecular design, genetic manipulation, expression and 
    purification of protein chimeras, which either bear functional groups or assemble spontaneously 
    into nano-arrays. Tasks will also include the biophysical analysis of samples and X-ray 
    crystallographic studies directed to validate the design principles. The successful applicant 
    will work in the group of Olga Mayans at the Division of Structural Biology, Biozentrum 
    (University of Basel), and the visualization and manipulation of nano-objects will be performed 
    under the supervision of Laurent Kreplak in collaboration with the Swiss Nanoscience Center. The 
    Division of Structural Biology at Biozentrum is fully equipped for the structural analysis of 
    proteins and large assemblies using NMR, electron microscopy, atomic force microscopy and X-ray 
    crystallography. A full range of protein expression systems are in operation for sample production 
    and multiple biophysical techniques are available for sample characterization.
    
    Requirements: a strong background in molecular biology, protein engineering and/or ab initio 
    protein design is required as well as strong experience in protein production and purification. 
    Initial familiarity with a structural or biophysical technique will be of distinct advantage, 
    although full training in X-ray crystallography and microscopy techniques will be provided.
    
    Applications should be in the form of a comprehensive CV, a one-page summary of past work and contact details 
    for two referees.
    
    Starting date: 1st July 2006
    
    For enquiries and applications contact Olga.Mayans@unibas.ch.
    
    The search is now open and will continue until the position is filled.
    
    University of Basel offers an international and stimulating environment for interdisciplinary research in 
    nano-biosciences. Located at the interface of three countries and in the proximity of the Alps, Basel 
    enjoys a richness of multicultural, recreational and sport activities.
    
    www.biozentrum.unibas.ch
    


    Postdoctoral position in protein complex crystallography

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    SPINE II - Barcelona, Spain
    
    Applications are invited for a postdoctoral position at the Institut de
    Recerca Biomédica / Institut de Biologia Molecular de Barcelona (CSIC) to
    work on the structural characterization of protein complexes. The position
    is supported by a recently awarded EU Integrated Project - SPINE II
    Complexes: From Receptor to Gene: Structures of complexes from signalling
    pathways linking immunology, neurobiology and cancerî. A strong background
    in protein expression is required.
    
    Our laboratory is equipped with state-of-the-art protein expression and
    purification apparatus, including high-throughput facilities. The
    crystallographic equipment includes nano-drop crystallization robots,
    storage and visualization robots, two rotating anode generators (one a
    MicroMax-007 micro-focus generator) with image plate detectors, and
    cutting-edge computational facilities. The Institute is located in the
    stimulating scientific and cultural environment of the Barcelona Science
    Park.
    
    Those interested should contact (preferably by email):
    Prof. Miquel Coll
    Institut de Recerca Biom&eaucte;dica &
    Institut de Biologia Molecular de Barcelona (CSIC)
    Parc Científic de Barcelona, Josep Samitier 1-5
    08028 Barcelona, Spain
    
    Email   vllobet@pcb.ub.es; vllobet@ibmb.csic.es
    URL:    www.irbbarcelona.org 
    
    Applicants should send a full curriculum vitae and the names and addresses
    (including e-mail address) of two referees.
    


    bgcolor="CCCCCC">

    Postdoctoral position in protein crystallography

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    CRYSTAX - Barcelona, Spain)
    
    Applications are invited for a postdoctoral position at the Institut de
    Recerca Biomédica / Institut de Biologia Molecular (CSIC) to work on the
    structural characterization of drug-protein complexes. The position is
    supported by a joint research project (CENIT) between our laboratory and the
    biotech company CrystaX Pharmaceuticals. The project is part of a drug
    discovery effort and consists of the structural characterization of small
    ligand-protein complexes. The proteins examined are relevant pharmacological
    targets in field of cancer therapeutics. A strong background in protein
    crystallography is required.
    
    Our laboratory is equipped with state-of-the-art protein expression and
    purification apparatus, including high-throughput facilities. The
    crystallographic equipment includes nano-drop crystallization robots,
    storage and visualization robots, two rotating anode generators (one a
    MicroMax-007 micro-focus generator) with image plate detectors, and
    cutting-edge computational facilities. The Institute is located in the
    stimulating scientific and cultural environment of the Barcelona Science
    Park.
    
    Those interested should contact (preferably by email):
    
    Prof. Miquel Coll
    Institut de Recerca Biomédica &
    Institut de BiologÌa Molecular de Barcelona (CSIC)
    Parc Científic de Barcelona, 
    Josep Samitier 1-5 08028 Barcelona, Spain
    
    Email   vllobet@pcb.ub.es;  vllobet@ibmb.csic.es
    URL:    www.irbbarcelona.org
    
    Applicants should send full curriculum vitae and the names and addresses
    (including e-mail address) of two referees.
    


    Research scientist position: crystal growth at MSGPP in Seattle

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    Medical Structural Genomics of Pathogenic Protozoa (MSGPP)_
    University of Washington, Seattle_
    
    
    The successful candidate will become a member of the unit within the
    multi-disciplinary Medical Structural Genomics of Pathogenic Protozoa
    (MSGPP) Project which focuses on the growth of high quality protein
    crystals for X-ray structure determination by high-throughput methods.
    The proteins are derived from organisms responsible for major global
    diseases such as malaria, sleeping sickness, leishmaniasis, and others.
    Characterization and purity of protein samples will be assessed by
    several biological and/or biochemical techniques to be followed by
    carefully planned small scale crystallization experiments using
    pipetting as well as robotic techniques. Great care in preparation and
    execution of experiments is required. Excellent tracking of results with
    spreadsheets and databases will be crucial. Participation in development
    for new protocols and new tools for protein crystallization will be an
    important component for this position. Special emphasis will be given to
    co-crystallization of proteins in complex with Ligands to enhance
    insight in small molecule-binding properties of the drug target proteins
    under investigation.
    
    Specific responsibilities include:
    
    
  • performing protein characterization with a variety of methods including
  • Limited proteolysis experiments
  • Dynamic light scattering studies
  • Determination of purity with gel electrophoresis techniques
  • Protein crystallization experiments
  • Programming robots to prepare solutions and set up crystallization experiments
  • Preparing stock solutions
  • Performing the crystallization by robotics
  • Performing follow up crystallization experiments manually
  • Analyzing crystallization results
  • Preparing screening overviews When needed, protein samples will be further purified or modified as e.g. by reductive lysine methylation or other procedures. Requirements A BSc in biochemistry, chemistry or related field with at least one year experience in protein purification and protein chemistry. Experience with handling protein solutions, and with protein purification methods is required. Experience with protein crystallization methods as well as use of robots is a plus. Excellent interpersonal skills. The University of Washington is an affirmative action, equal opportunity employer. Women and minorities are encouraged to apply. Please send your applications with a resume and three references, with email addresses and telephone numbers, to Wim Hol at wghol@u.washington.edu at the University of Washington, Seattle. Useful websites are: http://www.sgpp.org/ (this covers SGPP, the precursor of MSGPP); http://www.bmsc.washington.edu/WimHol/ http://depts.washington.edu/biowww/faculty/hol.html

  • Postdoctoral position available

    Date posted: 29 April, 2006

    Deadline for applications: 25 May, 2006

    Announcement will be removed: 26 May, 2006

    Postdoctoral position in high throughput approaches (MPI Dortmund, Germany)
    
    Job Description: 
    The Center of Systems Biology of the Max-Planck Institute in Dortmund (Germany) has an 
    active research program in Chemical biology, Biophysics and structural molecular biology 
    which is been now expended to a new Systems Biology program. We are seeking a post-doctoral 
    candidate who in conjunction with other scientists of the institute would supervise a group 
    of initially two technicians and an engineer to develop new approaches for expressing 
    proteins and analyzing their interactions using automated high-throughput protein expression 
    and analysis. Close collaboration with structural biology and bio-and chemistry units will 
    be a must.
    
    Qualifications & Experience: Candidates should hold a Ph.D. and be able to demonstrate 
    excellence in molecular biology, protein expression and purification. Experience in 
    high-throughput methods, directed evolution, protein engineering and laboratory automation
    is preferred and an interest in structural biology is very welcomed.
    
    The position is for 2 years initially. To apply, please send your CV together with other 
    relevant documents and the names and contact details of three referees. 
    
    Closing date is the 25th of May 2006.
    
    For further information please contact Dr. Kirill Alexandrov at kirill.alexandrov_at_mpi-dortmund.mpg.de
    
    


    Postdoctoral position available

    Date posted: 29 April, 2006

    Deadline for applications: 25 May, 2006

    Announcement will be removed: 26 May, 2006

    Post-doc position in structural biology, MRC, Cambridge
    
    Career Development Fellowship
    
    The MRC Dunn Human Nutrition Unit (Director: Professor Sir John Walker) wishes to appoint 
    a Post-doctoral Scientist to undertake research into the structure of bacterial 
    respiratory complex I, as a member of Dr Leo Sazanov’s group. You should have a PhD in a 
    relevant subject and preferably some experience in protein crystallisation, X-ray data 
    collection and model building/refinement.
    
    Complex I of respiratory chains plays a central role in cellular energy production and is 
    implicated in human neurodegenerative diseases and ageing. We have determined the first 
    atomic structure of the catalytic core of this large molecular machine (Sazanov, L.A. and 
    Hinchliffe, P. (2006) /Science/, *311*, 1430-1436; Hinchliffe, P. and Sazanov, L.A. 
    (2005) /Science/, *309*, 771-774). Our aims now are to determine the structure of the 
    catalytic domain in the presence of substrates, and to solve the structure of the entire 
    complex by X-ray crystallography.
    
    This is a three-year training and development position for a Post-doctoral Scientist who 
    has recently completed their doctoral studies, is moving into a new research discipline 
    or has limited previous experience of key transferable skills. The post provides 
    opportunities to develop research project skills and collaborative links with colleagues 
    within the Medical Research Council and elsewhere.
    
    The work will be carried out at the Dunn Human Nutrition Unit, a world-renowned centre 
    for Bioenergetics research. A full job description and additional information about the 
    unit can be found at _www.mrc-dunn.cam.ac.uk _. Informal 
    enquiries may be addressed to Dr L.A. Sazanov by email: sazanov@mrc-dunn.cam.ac.uk.
    
    The starting salary will be in the range of £24,746 - £25,766 per annum, depending upon 
    qualifications and experience. This is supported by a flexible pay and reward scheme, and 
    optional MRC final salary pension scheme.
    
    *Applications should include a covering letter and full CV, with the contact details of 
    two professional referees who can be approached prior to interview. Quoting job reference
    DHNU/406/6, please email your application to: ***recruit@mrc-centre.cam.ac.uk*** 
    or post to: Recruitment Office, Personnel Department, MRC Centre, Hills Road, Cambridge CB2 2QH.**
    
    **Closing date: 25th May 2006***
    


    Director of Systems Engineering - Orinda, CA

    Date posted: 29 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 29 July, 2006

    Director of Systems Engineering
    
    Seeking a Director, Systems Engineering for a great technology company
    located in Orinda, CA.  Here are the details on the position:
    
    GENERAL PURPOSE OF JOB
    Responsible for evangelizing Company‚s service, functioning as a technical
    consultant during the sales process, and overseeing  deployments on an as
    needed basis to enterprise software manufacturers. Includes management of
    Boston based Systems Engineer.
    
    ESSENTIAL DUTIES AND RESPONSIBILITIES
    
    Frequently:
    Provide product demonstrations to prospects and partners demonstrating the
    value of a hosted solution for the delivery of software and licenses
    Engage with prospects to evangelize the platform and effectively communicate
    Company‚s value proposition
    Develop proof of concept and pilot implementations rapidly and effectively
    for prospects and customers
    Manage SE resources effectively to ensure appropriate national coverage for
    sales opportunities
    Interact with Company‚s engineering and IT group to effectively communicate
    key trends in the marketplace as indicated by prospects, partners and
    customers
    
    Regularly:
    Travel to customer locations in the Western half of the US.
    
    Occasionally:
    Engage with new Company customers immediately post sale and remain the
    primary Company point of contact for the customer until the hosted site has
    been launched for production use
    Interact as the key technical point of contact for Company‚s existing and
    future partners
    Responsible for the development of an implementation plan that is consistent
    with deployment methodology, and the execution of work by internal company
    and customer resources
    Use traditional project management techniques such as deliverable and
    responsible party identification, issues tracking and management, and
    communication planning
    Represent Company in public speaking engagements such as webinars, customer
    conferences, third party industry events etc
    Oversee and manage technology projects (e.g. documentation).
    Travel by air to customer locations.
    
    LEADERSHIP AND SUPERVISION
    Determines methods and procedures on new assignments and may coordinate
    activities of other personnel for specific project implementations.
    
    SUPERVISORY RESPONSIBILITIES
    Manage the East Coast SE based in the Boston office.
    
    EDUCATION and/or EXPERIENCE
    Bachelor‚s degree (B A., B.S.) from a four-year college or university; or
    five to eight years related experience and/or training; or equivalent
    combination of education and experience. A degree in Computer Science or
    Engineering is highly preferred.
    
    REQUIRED SKILLS AND ABILITIES
    Exceptional presentation skills with the ability to communicate effectively
    at all levels of an organization
    Capable of quickly and effectively creating white papers and other technical
    documentation
    Ability to analyze complex business environments and develop solutions
    highlighting the value of the service
    Proficiency and significant experience using SQL, XML, XSLT, and Java
    technologies
    Experience working with a hosted application
    Prior experience leading project implementations either as a project manager
    or technical lead
    
    OTHER QUALIFICATIONS
    Prior experience with Digital Rights Management or Licensing Technologies is
    highly desired. Prior experience with hosted ASP models also a strong plus.
    Excellent social and diplomatic skills
    Highly motivated self-starter
    Flexibility for travel
    Excellent analytical skills
    Communicate effectively and positively with a variety of people.
    Build and maintain positive relationships with clients and co-workers;
    inspire cooperation and confidence
    Demonstrate strong persuasive skills, professional maturity, and sound
    judgment in varied situations
    Contribute toward and build positive morale
    Handle situations with poise, understanding, and tact
    Maintain composure and focus under pressure and deadlines
    Demonstrate organizational skills and attention to detail
    Sustain productivity in a fast paced environment
    Ability to independently prioritize multiple tasks and to work autonomously,
    without day-to-day direction
    
    Department: Sales
    Reports to: VP of Sales and Marketing
    Status: Exempt
    Location: Orinda, CA
    
    If you are interested, please forward your:
    
    -resume
    -salary requirement
    -work authorization  (sponsorship is not available for this opportunity)
    -relocation considerations (or commute information)
    
    to resumes@workwondersstaffing.net
    


    Postdoctoral position available

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    Postdoctoral opportunity in Boston
    
    We have recently discovered that a T cell receptor from a patient with an
    autoimmune disease, multiple sclerosis, binds with a highly unusual topology to
    its self-peptide/MHC target (Nature Immunology 2005; 6: 490-6).  The topology
    differed from all human T cell receptors specific for viral peptides, all of
    which bind to peptide/MHC with a very similar topology.  These findings raise a
    number of interesting questions:  Are altered topologies also observed for T
    cell receptors in other autoimmune diseases?  What is the range of possible
    topologies?  How do altered topologies modify early T cell receptor signaling
    events?
    
    We are recruiting a postdoctoral fellow to this project, with the goal of
    determining the structures of T cell receptors from other autoimmune diseases by
    X-ray crystallography.  The candidate should have experience in protein
    expression and purification and preferably also have experience in structure
    determination.  The Dana-Farber Cancer Institute and Harvard Medical School
    offer a stimulating intellectual environment in structural biology and
    immunology.  To learn more about the research in the lab, visit our lab website
    at http://research.dfci.harvard.edu/tcell
    
    Please send resume and names/telephone/email of three references to Kai
    Wucherpfennig at Kai_Wucherpfennig@dfci.harvard.edu
    


    Want Sun?? Post-Doc opportunity in UCLA

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    University of California, Los Angeles
    
    
    DESCRIPTION/REQUIREMENTS: 
    An NIH-funded postdoctoral position is available immediately 
    for a highly motivated individual with a strong interest in 
    structure and function of membrane transport proteins in the 
    laboratory of Dr. Jeff Abramson at the Department of Physiology, 
    University of California Los Angeles (UCLA). The project aims to 
    elucidate the structure and function from members of the Na+/
    Glucose cotransporter family (SGLT). These proteins perform 
    essential roles in physiology and are implicated in a number of 
    diseases most notably infectious diarrhea, diabetes and some 
    cancers. 
    The Lab is well equipped for structural biology including state-
    of-the-art crystallization robotics. We also have full access to 
    the Molecular Biology Institute's (MBI) X-ray core facility 
    featuring a Rigaku FRD generator using the RAXIS IV++ and 
    Quantum 4 CCD detectors. There is a large computational 
    cluster and monthly access to the ALS synchrotron in Berkley, 
    California. UCLA has a strong and highly collaborative 
    macromolecular crystallography program in place with 6 
    faculties and 50 students, staff and postdocs. 
    Los Angeles is a cosmopolitan city with 330 days a year of 
    perfect weather. Sunny beaches and hiking trails are just a few 
    minutes away and skiing within hours.  There are also number of 
    museums and playhouses within walking distance from the 
    university.
    
    APPLICATION PROCEDURE: 
    The successful applicant will hold a PhD and have ample 
    knowledge in modern macromolecular crystallographic methods 
    as well as experience in data collection and processing. 
    Knowledge of membrane protein expression/purification and/or 
    mammalian cell culture would be a plus. The candidate must 
    possess excellent written and oral communication skills, and will 
    be expected to work in a diverse and highly collaborative 
    environment. 
    
    If interested, please send a CV, three references, and a cover 
    letter explaining your research interests to Jeff Abramson: 
    jabramson@mednet.ucla.edu 
    
    CONTACT PERSON: Jeff Abramson
    David Geffen School of Medicine
    CHS 53-254
    Los Angeles, California 90095
    USA
    


    Protein Crystallography PhD Studentship

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    Applications are invited for BBSRC PhD studentships (3-yr) to start in
    October 2006. The award is available for UK candidates or resident EU.
    The ideal candidate should have a solid undergraduate background in molecular biology, 
    protein biochemistry and/or biophysics.
    
    Structural biology of novel RNA binding proteins
    
    Novel protein GURB was recently identified as an RNA binding protein and a potential 
    translational regulator of cell cycle controlling proteins in Xenopus oocytes by 
    Cornelia de Moor's laboratory. The protein has turned up in several other proteomic 
    studies that analysed RNP complexes, including in mRNA transport particles in neurons 
    (de Hoog et al., 2004). GURB homologues have not been functionally charcterised in any 
    species, but the protein is unusually well conserved (~50% identity) amongst animals and 
    bacteria, including human and E. coli, suggesting an important role in cell physiology. 
    GURB lacks any of the known RNA binding domains. The structural characterisation of GURB 
    will lead to the description of a new RNA binding domain, defining a novel protein family. 
    
    The work done on this project will contribute to the study of the function of GURB that 
    is part of the Wellcome project currently active in Dr. de Moor's laboratory. 
    Translational control is currently a very fast moving field, especially the translational 
    control at synapses and in the cell cycle (Huang and Richter, 2004), and this work could 
    bring a new dimension to it.
    
    This research area requires a multidisciplinary approach, and uses cell biological, 
    biochemical techniques in conjunction with X-ray crystallography 
    (http://www.nottingham.ac.uk/~pazxtal/). 
    
    Phd students are provided with the opportunity to attend external training courses for 
    developing skills in crystallographic methodology (usually hosted by the synchrotron 
    organisation in Grenoble).
    
    Facilities available include a protein crystallization laboratory fully-equipped with X-r
    ay data collection and crystallisation robot etc.
    
    Dr Jonas Emsley
    Reader in Crystallography,
    Centre for Biomolecular Sciences,
    University of Nottingham,
    Nottingham, NG72RD
    tel: 01158467092
    fax:01158468002
    email:jonas.emsley@nottingham.ac.uk
    http://www.nottingham.ac.uk/~pazxtal/
    http://www.nottingham.ac.uk/~pazweb2/lookup/roles/acad_admin/EmsleyJ.phtml
    


    Postdoctoral position available

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    Post-doctoral position - Structural biology of microtubule assembly
    
    A post-doctoral fellowship funded by the french National Agency for
    Research is available immediately at the Laboratoire d'Enzymologie et
    Biochimie structurales (LEBS), CNRS, Gif-sur-Yvette, France. The
    contract will be for a period of up to three years, with an annual
    salary of 25.700&Euro;.
    The research will be on the structural study of the regulation of
    microtubule assembly by endogeneous proteins. Applicants should hold a
    PhD, have experience in biochemistry (protein expression, purification
    and biochemical characterization) and an interest in structural
    studies. Experience in protein crystallization and crystallography
    would be an advantage.
    The LEBS is well equipped for protein purification and characterization
    by biochemical and biophysical methods. Crystallization robotics and
    X-ray crystallography equipment are available in-house and we have
    regular access to synchrotron sources. The lab is located in a,
    multidisciplinary life sciences campus, 40 minutes by direct train from
    the centre of Paris.
    To apply, please send a CV, a short summary of your research experience
    and the names and contact information of two referees by e-mail to :
    Dr. Marcel Knossow
    E-mail: knossow@lebs.cnrs-gif.fr
    
    More information on our group can be found on our web page :
    http://www.lebs.cnrs-gif.fr/knossow/knossowang.html
    
    


    Postdoctoral position available

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    A post-doctoral position is available immediately in the laboratory of
    Barnali Chaudhuri at the Hauptman-Woodward Institute (HWI,
    http://www.hwi.buffalo.edu/), Buffalo. The goal of the project is to study
    the mutual recognition processes between RNA and eukaryotic RNA modification
    enzymes using X-ray crystallography and other bio-physical tools.
    
    A talented individual with recent Ph. D. degree in chemistry, biochemistry,
    molecular biology or related area will be an ideal candidate. Prior
    experience in cloning/expression or protein purification is desirable. The
    position is available initially for 1 year and can be extended up to 3
    years. HWI offers a competitive salary and excellent benefits.
    
    HWI provides an intellectually stimulating and collegial environment where
    mathematicians, physicists, chemists and biologists collaborate to
    understand bio-molecular functions in terms of their physical and chemical
    properties. We have all the facilities required for modern-day
    crystallography including an in-house high-throughput crystallization
    laboratory.
    
    Interested candidates may send a copy of CV, summary of previous research
    and accomplishments and arrange to send three references to
    bchaudhuri@hwi.buffalo.edu
    
    Barnali Chaudhuri, Ph. D.
    Research Scientist
    Hauptman-Woodward Medical Research Institute
    Assistant Professor
    Dept. of Structural Biology,
    School of Medicine and Biomedical Sciences
    SUNY at Buffalo
    http://www.hwi.buffalo.edu/
    Phone: 716 898 8681
    Fax:  716 898 8660
    


    Postdoctoral position available

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    A NIH-funded postdoctoral position is immediately available to continue our
    previous study on crystal structures of hematology-related proteins (Nature
    Structural Biology, 2003,10:751, Science, 2006,311:656). 
    
    The Division of Haemostasis and Thrombosis Research at Beth Israel Deaconess 
    Medical Center, Harvard Medical School, has a dynamic research environment, 
    employing multi-disciplinary approaches to the study of blood coagulation and 
    vascular biology. 
    
    Applicants must be a US citizen or permanent resident, hold a PhD
    or MD or combined degree and, preferably, experience in protein X-ray
    crystallography. 
    Interested persons should send a CV and arrange three reference letters to 
    mhuang1@bidmc.harvard.edu or bfurie@bidmc.harvard.edu.
    


    Post Doc (NIH funded) Position

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    Protein chemists and structural biologists are encouraged to apply for NIH
    funded (Grant Number:  2R01GM057568-05A1) post-doctoral opportunities in the
    Departments of Chemistry and Biomolecular Sciences at the University of
    Central Florida in Orlando, FL.  
    
    This project is in the area of inhibitor design and structure determination of novel phospho-inositol cleaving enzymes.  
    
    Applicants are required to have a PhD.  
    
    Experience in protein purification and/or protein crystallography is preferred.  
    Training in the area of high throughput protein purification, and molecular biology
    techniques as well as crystallography is available.  
    
    Salary will be commensurate with experience and follow NIH guidelines.  
    
    Applicants should send a CV, cover letter with statement of interest and list of 
    references to
    
    Professor Thomas Selby (tselby@mail.ucf.edu), 
    University of Central Florida,
    Chemistry Department, 
    4000 University Blvd., 
    Orlando FL 32816-2366.  
    (See http://www.cas.ucf.edu/chemistry/faculty_selby.php for further information.)
    


    Postdoctoral position available

    Date posted: 19 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 19 July, 2006

    Postdoctoral position in structural analysis and molecular modeling
    
    The Medical Structural Genomics of Pathogenic Protozoa (MSGPP) Project at the University 
    of Washington, Seattle, is determining crystal structures of targeted proteins from major 
    global pathogens. The crystal structures are preferably solved in the presence of known 
    inhibitors or small molecular “fragments”. The pathogens under study are of major 
    importance to human health; these include, Plasmodium falciparum and vivax, Toxoplasma 
    gondii, Trypanosoma cruzi and brucei, Leishmania major and infantum, Entamoeba 
    histolytica, Giardia lamblia, and Cryptosporidium parvum. The structures determined will 
    be used for experimental drug screening as well as for virtual screening of potential 
    inhibitors. The ultimate goal is to arrive at target protein complexes with ligands that 
    might form the basis for medicinal chemistry efforts.
    
    Job description: The post-doctoral fellow will analyze the solved structures to identify 
    and characterize key functional sites in the proteins; discover by computational methods, 
    such as molecular docking, ligands that bind the key sites; design small focused compound 
    libraries from crystallographically verified initial ligand binding modes, in dialogue 
    with synthetic chemists. Excellent software and hardware is available.
    
    Qualifications: Required – Ph.D. in computational chemistry or protein x-ray 
    crystallography. Strongly desired - Experience with computational methods of 
    protein structure analysis and molecular docking; familiarity with Linux, scripting 
    languages, protein sequence databases and tools. Excellent interpersonal skills and 
    the ability to work in a team are critical.
    
    The position is immediately available.
    
    Contact: Christophe Verlinde, Ph.D. E-mail to verlinde@u.washington.edu
    CV, and 3 references are required.
    The University of Washington is an affirmative action, equal opportunity employer.
    


    Senior Scientist, Protein Crystallography, New York, NY

    Date posted: 6 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 6 July, 2006

    Recruitment a Senior Scientist with a strong background in protein crystallography for a great company located in New York City.
    
    Here is more information:
    
    JOB RESPONSIBILITIES
    Primarily include applications work with new x-ray refinement software
    package, on- and off- site formal presentations and demonstrations of
    software, and continued software design and prioritization of enhancements.
    Collaborative projects with customers, presentations at scientific meetings,
    and publishing in peer reviewed journals is encouraged.
    
    REQUIRES
    A strong background in computational chemistry with application to
    biological problems is highly desired.
    Exceptional communication skills and an outgoing personality.
    Ph.D. in Chemistry (or related field) plus experience using protein
    crystallography for understanding ligand/protein interactions and extensive
    experience refining protein/ligand complexes
    Post-doctoral research and/or relevant experience in the commercial sector
    A broad knowledge of molecular modeling theory and applications
    Familiarity with PERL and/or Python desired
    
    COMPANY:
    A technology leader specializing in software solutions for life science
    research and development.
    
    COMPENSATION
    This client will offer above-market compensation and a great benefits
    package to candidates of truly exceptional ability. Relocation/visa
    sponsorship is not a problem.
    
    APPLY
    For consideration, please send CV (including publications, thesis topic, and
    advisor), salary requirement or history, work authorization and a few
    references to resumes@workwondersstaffing.net.
    


    Open Postdoc and PhD Positions

    Date posted: 4 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 4 July, 2006

    Genzentrum LMU Munich/GSF (Munich, Germany)
    
    The Niessing laboratory at the Gene Center of the Ludwig-Maximilians
    University (LMU) Munich (Germany) studies the structure-to-function 
    relationship of motor protein-dependent transport complexes, using a 
    combination of X–ray crystallographic, biophysical, biochemical, and 
    in vivo approaches. The Niessing lab is jointly funded by the GSF, 
    the Helmholtz Association, and the Genzentrum LMU.
    
    For more information, see http://www.lmb.uni-muenchen.de/niessing/
    
    We wish to fill the following positions:
    
    One Postdoctoral Fellow: The candidate is first author of at least one
    peer-reviewed publication (or manuscript in preparation), has expertise
    in crystallography and biochemistry, only recently obtained a PhD
    degree, and sees her/ himself as team player (for full advertisement,
    see also http://www.gsf.de/neu/Jobs/index_en.php)
    
    One Predoc (PhD): The candidate has experience in biochemistry/molecular
    biology and a strong interest in understanding the structure-to-function
    relationship of protein complexes. Practical experience in structure
    biology is not required, but the ability to work as team player is
    mandatory.
    
    The Gene Center LMU is an interdisciplinary research institute, offering
    an excellent research environment and infrastructure for X–ray
    crystallographic and functional studies. It is located at the Campus
    Grosshadern/Martinsried in Munich, which hosts various University Institutes, 
    the GSF (Helmholtz Institute), two Max-Planck Institutes, the University 
    Hospital Grosshadern, and the Biotechnology Center IZB.
    
    
    Applications (cover letter, CV, names of referees)
    should be preferentially sent by e-mail to:
    Dr. Dierk Niessing
    Gene Center, LMU Munich
    Feodor-Lynen-Strasse 25
    81377 Munich, Germany.
    
    E-mail: niessing@lmb.uni-muenchen.de or dierk.niessing@gsf.de
    
    The GSF and LMU are equal opportunity employers and wish to increase
    their number of female scientists.
    
    


    Post doc positions at Diamond Light Source

    Date posted: 4 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 4 July, 2006

    Post doc positions at Diamond Light Source
    
    Positions are available to join the MX team within the Life Science
    division at the Diamond Light Source, the new UK synchrotron currently
    in the final stages of construction in Oxfordshire. We will have 3
    state-of-the art macromolecular crystallography beamlines which we will
    be commissioning during 2006 in order to begin operations in 2007. Your
    duties will be to help commission the beamlines, in particular the
    experimental equipment, interact with our user community to develop and
    provide appropriate user support, and to take part in our in-house
    research projects which currently cover a wide range of projects from
    instrumentation through to membrane protein crystallography. We have
    busy but also exciting years ahead of us, and we count on you to be as
    enthusiastic as we are about the technical and scientific challenges we
    face. We look forward to welcoming you to Diamond.
    
    For more information go to http://www.diamond.ac.uk/mx
    
    Full posting can be found at
    http://www.diamond.ac.uk/Jobs/CurrentVacancies/Scientific/DIA0205LV.htm
    
    For further information please do not hesitate to contact Liz Duke,
    Gwyndaf Evans or Thomas L-M Sorensen.
    


    PhD position available at the University of Cologne

    Date posted: 4 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 4 July, 2006

    A PhD position in structural biology funded by the Deutsche
    Forschungsgemeinschaft (DFG) is available at the Institute of Biochemistry
    of the University of Cologne.
    
    Please find details
    - about the project under
    http://www.hnb-cologne.uni-koeln.de/WWW/m_staff/kni/PhD.pdf
    
    - about Cologne under
    http://www.stadt-koeln.de/en/koelntourismus/index.html
    
    Applications should be sent to:
    Dr. Karsten Niefind, University of Cologne, Institute of Biochemistry,
    Zülpicher Str. 47, D-50674 Köln, Tel.: 0049/221/470 6444, E-mail:
    Karsten.Niefind@uni-koeln.de
    


    PhD at the Institute of Structural Biology (IBS), Grenoble

    Date posted: 4 April, 2006

    Deadline for applications: unknown

    Announcement will be removed: 4 July, 2006

    PhD fellowship available
    
    Development of powder diffraction methods for the study of biological
    macromolecules
    (http://www-instn.cea.fr/html/F_cfr/sujet2006/index.html)
    
    
    The Institute of Structural Biology (IBS, Grenoble, France) in
    collaboration with the European Synchrotron Radiation Facility (ESRF,
    Grenoble, France) invite applications for a PhD research Fellow in the area
    of macromolecular crystallography.  The aim of the present research project
    is to develop data collection and data processing methods for the study of
    biological macromolecules by means of powder diffraction.
    
    The successful candidate will be part of a wide research network, currently
    including universities (Ecole Polytechnique Federale de Lausanne (EPFL)),
    research institutes (IBS, ESRF, APS (USA), SPring8 (Japan)) and companies
    (PaNalytical, pharmaceutical companies). In January 2005 a related
    long-term proposal was accepted and awarded beam time on four ESRF beam
    lines over the three-year period 2006-2008. This is a major venture, in
    which the PhD project will concentrate on data-collection and analysis
    strategies, applied to various proteins with up to 300 residues (and
    possibly beyond).
    
    
    The position is funded by CEA, of which IBS is a partner, for up to three
    years.
    
    The ideal candidate should have a degree in physics, chemistry or biology.
    The position is based primarily at the IBS facility (Institut de biologie
    structurale) in Grenoble.  Diffraction experiments will be performed at the
    ESRF facility on existing instruments such as ID31, ID11, BM01 and BM16 but
    access to other facilities such as the European Molecular Biology
    Laboratory (EMBL) and the Partnership for Structural Biology (PSB) is
    likely during the course of the project.
    
    The post is immediately available. The call is open for a limited period of
    time.
    
    For further details of the project contact as soon as possible:
    
    Prof. Richard Kahn
    Laboratoire de Cristallographie MacromolÈculaire
    41 rue Jules Horowitz
    38027 GRENOBLE CEDEX 1
    Telephone : (+)33(0)438789645
    Email: richard.kahn@ibs.fr
    
    or
    
    Dr Irene Margiolaki
    European Synchrotron Radiation Facility (ESRF)
    ID31 high resolution powder diffraction beamline,
    6 Rue Jules Horowitz,
    BP 220, 38043 Grenoble, Cedex 9,
    France.
    Office: 30.01.08
    Tel. (+)33(0)476882148
    Fax. (+)33(0)476882907
    Email: margiolaki@esrf.fr
    
    


    NMR spectroscopist at AstraZeneca, Mölndal

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    NMR spectroscopist
    
    Proffice is one of the fastest growing companies within the Nordic region,
    according to Growth Plus. Proffice provides flexible staffing solutions such
    as temporary staffing, recruiting, outsourcing and career and development
    programs. Proffice operates in Denmark, Finland, Norway and Sweden. Proffice
    AB is listed on the Stockholmsbörsen (Stockholm Stock Exchange).
    
    Proffice is now looking for a scientist for a temporary position in
    biomolecular NMR spectroscopy in the NMR Group at the Structural Chemistry
    Laboratory, at the AstraZeneca research site in Mölndal, Sweden.
    
    The Structural Chemistry Laboratory is a research facility investigating
    protein structure and protein-ligand interactions to assist the entire
    AstraZeneca organization in the drug discovery process. The structural
    chemistry group in Mölndal consists of 40 people working in three closely
    integrated core disciplines: Protein Structure (X-ray crystallography),
    Biomolecular NMR, and protein engineering. This exciting environment
    stimulates creative and focused research, and offers excellent opportunities
    for personal and scientific growth.
    
    The NMR group contributes to about a dozen projects at any one time,
    covering the entire discovery process. Our activities range from lead
    discovery by investigating protein-ligand interactions with 1D and 2D NMR,
    to structure-based drug design by full structure determination. Constant
    development and implementation of new methods is required to keep pace with
    the increasing demands of drug-discovery research. The laboratory is one of
    the most technologically advanced in the world: we are equipped with a 800
    MHz spectrometer, and two 600s, both of them with cryoprobes and interfaced
    to state-of-the-art sample preparation robotic systems for high-throughput
    work. 
    
    The applicant should have an interest in all possible applications of
    biomolecular NMR, with a focus on studies of molecular interactions.
    Hands-on spectrometer experience is required, preferably obtained in studies
    leading to a PhD. A background in biochemistry or biophysics is a merit. The
    multidisciplinary environment in which we operate requires enthusiasm,
    flexibility and the ability to interact and communicate in a team.
    
    To apply for the position please visit our website: www.proffice.se
    . Easily attach CV and personal letter. For
    additional information about the position, please contact Anita Gustafsson,
    Proffice Life Science 031-80 76 05 or Rutger Folmer at Structural Chemistry,
    AstraZeneca R&D, 031 - 776 2043
    
    Arbetstid/Varaktighet: Ett års vikariat
    
    Lön:Lön enligt avtal.
    


    Computational Chemist - Aurigene Discovery Technologies, India

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    Aurigene Discovery Technologies, India
    
    We are looking for a bright, talented post graduate or a fresh doctoral
    candidate. The ideal candidate should have sound knowledge of computational
    chemistry and some experience in the application of computational techniques
    such as QSAR and pharmacophore design and docking. Candidates who have a
    knowledge of protein structure will be preferred. Successful candidates will
    work closely with medicinal chemists and suggest potential hit/lead
    molecules.
    
    Aurigene Discovery Technologies is an integrated drug discovery organization
    with state-of-the-art infrastructure in all areas viz., molecular modeling,
    medicinal chemistry, protein science, assay biology and pre-clinical
    biology. Aurigene has exciting collaborations and vibrant internal programs.
    For more information about us, please visit www.aurigene.com.
    
    Interested candidates may please send their CVs to careers@aurigene.com with
    Job Code CompChem-Aurigene-001.
    
    


    Postdoctoral position available

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    Persons interested in postdoctoral positions in Australia
    may be interested in the following:
    
    http://rsc.anu.edu.au/Positions/RSC3316_PACKAGE.html
    
    In particular a postdoctoral position in protein crystallography
    is available. The successful applicant will work on the human
    omega-class glutathione transferase, an enzyme involved in
    recycling of vitamin C and in arsenic metabolism.
    
    Aaron Oakley
    Structural Biology Group
    Research School of Chemistry
    Australian National University
    Science Road
    Canberra
    ACT 0200
    Australia
    


    Postdoctoral position available

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    Protein Crystallography / Structural Biology
    
    Applications are invited for a one-year postdoctoral position with a possible
    extention of two years at the Department of Biochemistry and Biophysics,
    Stockholm University, Sweden. The position requires a Ph.D. in structural
    biology, biochemistry or a closely related field. The ideal candidates will
    have an interest in protein structure and function, and preferably experience
    in protein crystallization and/or structure determination by X-ray
    crystallography.
    
    The project involves protein purification, crystallization and structure
    determination of metalloproteases in collaboration with groups studying the
    molecular biology and biochemistry of these molecules. We recently determined
    the structure of presequence protease PreP from A. thaliana, which will soon be
    published in EMBO J. We continue our studies with human PreP as well as other
    members from the same protease family (diffracting crystals are available).
    
    The laboratory is located at Karolinska Institute and has excellent facilities
    for X-ray crystallographic studies. The institute offers a stimulating
    environment for research and its central location in Stockholm is readily
    available by public transportation.
    
    Please send CV and contact information for at least two references by email or
    fax to:
    
    Dr. Therese Eneqvist (eneqvist@dbb.su.se)
    Therese Eneqvist, Assistant Professor
    Department of Biochemistry and Biophysics, Stockholm University
    ******************************************************************************
    Department of Medical Biochemistry and Biophysics (MBB)
    Karolinska Institute
    SE-171 77 Stockholm, Sweden
    Tel:    +46-8-524-86862
    Fax:    +46-8-524-86850
    


    Scientist position in protein crystallography at SSRL

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    The Structural Molecular Biology (SMB) group of Stanford Synchrotron Radiation Laboratory 
    (SSRL, a division of SLAC) at Stanford University has an immediate opening for a Beam 
    Line scientist. The successful candidate will work as a member of the Structure 
    Determination Core (SDC) of the Joint Center for Structural Genomics (JCSG). The JCSG is 
    one of four production centers funded by the NIH/NIGMS Protein Structure Initiative. The 
    primary goal of the JCSG is to operate a high-throughput pipeline for macromolecular 
    structure determination (see http://www.jcsg.org). The Beam Line scientist will provide 
    beamline support for the JCSG group. These duties include the preparation of beamline 
    equipment prior to JCSG beam time and the troubleshooting of hardware/software problems 
    during the experiments. He/she will assist in the optimization of beamline optics and in 
    the maintenance, development and testing of beamline instrumentation. He/she will 
    participate in data collection and crystal screening activities, and will also assist in 
    structure determination and refinement.
    
    If you are interested in joining an enthusiastic team of scientists and developers, 
    working together on a challenging project then please review the job descriptions found at:
    
    http://www-public.slac.stanford.edu/hr/jobs/jobdetail.asp?REQID=029742
    
    Applications can be submitted online.
    
    Further enquiries can be addressed to Jessica Chiu (chiu@slac.stanford.edu).
    


    Postdoctoral positions in bioinformatics and systems biology

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    University of Leuven, Belgium
    
    As a new university initiative in Systems Biology, the University of Leuven
    has recently set up an interfaculty Center for Computational Systems Biology
    (SymBioSys) - http://www.kuleuven.be/symbiosys.
    
    The Center announces multiple openings for postdoctoral researchers in the
    area of systems biology, bioinformatics, and statistics
    
    Prerequisites
    Background in biology/molecular biology and a strong interest in informatics, 
    bioinformatics and statistics
    
    or
    
    Background in engineering/mathematics/statistics and a strong interest in biology
    
    The successful candidates will join a multidisciplinary research team within
    this Center of Excellence of the K.U.Leuven
    
    
    The University of Leuven (www.kuleuven.be) is located in the vibrant city of
    Leuven, Belgium, next to Brussels, and is the largest Belgian university
    with over 30.000 students.
    
    Specific research subjects and information on how to apply is available on
    the SymBioSys web site (http://www.kuleuven.be/symbiosys)
    
    K.U.Leuven is an equal opportunity employer
    


    Postdoc position in Brussels on crystallography of signal peptidases

    Date posted: 22 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 22 June, 2006

    We are looking to enrich our lab with an enthusiastic postdoc with a 
    protein crystallography background and experience in protein expression 
    and purification. Alternatively, a candidate with a biochemical background 
    and interest in structural biology will also be considered.
    The successful candidate will join a biochemistry/structural biology 
    lab of about 40 people that works on a variety of subjects: bacterial 
    toxin/antitoxin systems, bacterial adhesins and pilus formation, 
    nucleoside hydrolases, camel antibodies, redox enzymology and protein 
    transport though the cell membrane (see also our website at 
    http://ultr23.vub.ac.be/ultr/).
    
    The position is funded by the IWT (http://www.iwt.be/) for a maximum of 
    three years and involves the crystallization and structure determination of 
    soluble as well as membrane-associated forms of signal peptidases from 
    Staphylococcus epidermidis. The candidate will join an interuniversity 
    team focusing on signal peptidases as targets for drug development (see 
    attachment for a full description of the project).
    
    To apply, send your CV together with the names and contact details of 
    two academic referees to:
    
    Prof. Remy Loris (reloris@vub.ac.be)
    Vrije Universiteit Brussel
    ULTR
    Pleinlaan 2
    B-1050 Brussel
    Belgium
    
    


    Postdoctoral position available

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    Postdoctoral Position at Burnham Institute, La Jolla (CA)
    
    
    A Postdoctoral position is available immediately for studying the structural role of 
    signaling proteins involved in innate immunity. Approaches for these studies will combine 
    X-ray crystallography and NMR spectroscopy.
    
    Experience in any of these areas is required. Familiarity with basic molecular and cell 
    biology techniques will be valuable.
    
    The successful candidate must have a doctoral degree, a strong commitment to science, and the 
    capacity for independent work in a multidisciplinary environment.
    
    Please send curriculum vitae, a brief statement describing research experience
    and scientific interests and the names of at least two references to:
    
    Jaime Pascual, Ph. D.
    The Burnham Institute
    10901 North Torrey Pines 
    La Jolla (CA), 92037 (USA)
    http://www.burnham.org/
    email: pascual@burnham.org
    
    


    Professor position available

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    A full Professor position has been made available by the University of Marseille for the 
    AFMB lab*, with recruitment early 2006 and start on September 1st 2006.
    
    The position is for an experienced crystallographer with, if possible, an experience with 
    membrane proteins structure, able to perform/supervise the work tasks from gene to structure.
    
    - He/She will have full access to the protein expression and crystallization platforms 
    of AFMB and its technical staff.
    - He/She will be integrated in the group of Dr. Christian Cambillau, and will get his/her own 
    group after a few years.
    - The topics under study are GPCRs and Secondary Active Transporters.
    
    More information can be obtained from Dr. Christian Cambillau by phone (+33.491.825.590) 
    or e-mail (chris@afmb.univ-mrs.fr).
    
    *Architecture et Fonction des Macromolecules Biologiques lab. 
    home page: http://www.afmb.univ-mrs.fr/
    


    Crystallography post-doc position at UCLA

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    Crystallography post-doc position at UCLA
    
    An NIH-funded postdoctoral position is available immediately for a
    highly motivated individual with a strong interest in structure and
    function of membrane transport proteins in the laboratory of Dr. Jeff
    Abramson at the Department of Physiology, University of California Los
    Angeles (UCLA). The project aims to elucidate the structure and
    function from members of the Na+/Glucose cotransporter family (SGLT).
    These proteins perform essential roles in physiology and are implicated
    in a number of diseases most notably infectious diarrhea, diabetes and
    some cancers.
    
    The Lab is well equipped for structural biology including
    state-of-the-art crystallization robotics. We also have full access to
    the Molecular Biology Institute^Òs (MBI) X-ray core facility featuring a
    Rigaku FRD generator using the RAXIS IV++ and Quantum 4 CCD detectors.
    There is a large computational cluster and monthly access to the ALS
    synchrotron in Berkley, California. UCLA has a strong and highly
    collaborative macromolecular crystallography program in place with 6
    faculties and 50 students, staff and postdocs.
    
    Los Angeles is a cosmopolitan city with 330 days a year of perfect
    weather. Sunny beaches and hiking trails are just a few minutes away and
    skiing within hours. There are also number of museums and playhouses
    within walking distance from the university.
    
    The successful applicant will hold a PhD and have ample knowledge in
    modern macromolecular crystallographic methods as well as experience in
    data collection and processing. Knowledge of membraneprotein
    expression/purification and/or mammalian cell culture would be
    a plus. The candidate must possess excellent written and
    oral communication skills, and will be expected to work in a diverse
    and highly collaborative environment.
    
    If interested, please send a CV, three references, and a cover letter
    explaining your research interests to Jeff Abramson:
    jabramson@mednet.ucla.edu
    
    


    Senior Scientist, Protein Crystallographer - New York, NY

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    Senior Scientist, Protein Crystallographer - New York, NY
    
    I am assisting to recruit a Scientist Scientist with a strong background in
    protein crystallography for a great company located in New York city. Here
    is more information:
    
    COMPANY:
    A technology leader specializing in software solutions for life science
    research and development.
    
    JOB RESPONSIBILITIES
    Primarily include applications work with new x-ray refinement software
    package, on- and off- site formal presentations and demonstrations of
    software, and continued software design and prioritization of enhancements.
    
    Collaborative projects with customers, presentations at scientific meetings,
    and publishing in peer reviewed journals is encouraged.
    
    REQUIRES
    A strong background in computational chemistry with application to
    biological problems is highly desired.
    
    Exceptional communication skills and an outgoing personality.
    
    Ph.D. in Chemistry (or related field) plus experience using protein
    crystallography for understanding ligand/protein interactions and extensive
    experience refining protein/ligand complexes
    
    Post-doctoral research and/or relevant experience in the commercial sector
    
    A broad knowledge of molecular modeling theory and applications
    
    Familiarity with PERL and/or Python desired
    
    
    COMPENSATION
    This client will offer above-market compensation and a great benefits
    package to candidates of truly exceptional ability. Relocation/visa
    sponsorship is not a problem.
    
    APPLY
    For consideration, please send CV (including publications, thesis topic, and
    advisor), salary requirement or history, work authorization and a few
    references to resumes@workwondersstaffing.net.
    
    


    Postdoctoral position available

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    Postdoc position available in the Bujnicki group
    
    Applications are invited for an appointment as a Postdoctoral Fellow in the Bujnicki group 
    (Laboratory of Bioinformatics and Protein Engineering, International Institute of Molecular 
    and Cell Biology in Warsaw, Poland).
    
    The position will be funded by a 6FP MC-RTN grant:
    3-year contract, annual salary: Euro 30,000-34,000 + Benefits.
    
    The successful applicant will be involved in research in structural bioinformatics. 
    The position is research only and will involve the development of new methods for 
    structure prediction of proteins and/or RNA and their complexes. Experience in 
    programming is required (optimally Python and C++), familiarity with structural 
    bioinformatics and relational databases would be advantageous.
    
    Details are vailable at:
    http://www.genesilico.pl/employment.htm
    
    The deadline for this current round is March 20, 2006, but the positions
    will remain open until filled.
    
    Details about our lab may be found at
    http://genesilico.pl
    
    


    Post-doctoral position at Lund University

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    A postdoctoral position is available in the group of Dr. Derek Logan at the Department of 
    Molecular Biophysics, Lund University.  The successful applicant will participate in a 
    research project involving the structural and functional study of protein-protein complexes 
    in the extracellular matrix. Previous experience in molecular biology and protein expression 
    is a required. It will be considered an advantage to have worked with mammalian expression 
    systems. Experience of macromolecular crystallography is desirable but not essential. The 
    project will involve a combination of crystallography, electron microscopy and biophysical 
    characterisation.
    
    The Department of Molecular Biophysics (http://www.mbfys.lu.se) is a 
    small but lively one, with four research groups involved in macromolecular crystallography 
    and cryo-electron microscopy in a variety of different biological areas. We have frequent 
    access to the MAX-lab synchrotron, ten minutes walk from the Department, with its new MAD 
    beamline, Cassiopeia (http://cassiopeia.maxlab.lu.se). The 
    Department is well equipped for molecular biology and protein expression; non-bacterial 
    protein expression is done in collaboration with groups at the Biomedical Centre. Equipment 
    for low volume crystallisation and automatic drop inspection is available at MAX-lab (Tecan 
    Freedom Evo 150, Mosquito and Crystal Pro).
    
    Lund University, with seven faculties and a number of research centres and specialized 
    institutes, is the largest unit for research and higher education in Sweden. Lund University 
    was founded in 1666, partly in order to knit the provinces which had been ceded by Denmark in 
    1658 closer to Sweden. At present more than 38 000 students are enrolled and altogether some 
    6000 people are employed. Lund is an attractive university town with a rich cultural life and 
    within one hour by train from Copenhagen.
    
    Enquires and applications should be sent to Dr. Derek Logan at the address below or 
    preferably by e-mail to: derek.logan@mbfys.lu.se.
    
    Starting date: as soon as possible
    


    Post-Doc as a Protein X-ray Crystallographer

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    
    Bayer is a global enterprise with core competencies in three business 
    areas: health care, crop science and material science.  
    
    Bayer HealthCare is expanding its protein X-ray crystallography 
    group within the Medicinal Chemistry Institute of its Pharma 
    Research Center in Wuppertal, Germany. We are seeking a highly 
    motivated and qualified individual to fill the post-doc position as a 
    Protein X-ray Crystallographer. 
    
    Responsibilities: Your task will be to support drug discovery projects in
    various indications with state-of-the art protein expression, purification,
    crystallization and computational chemistry techniques. You will be
    involved in solving x-ray structures of lead compounds in complex with
    various target proteins and deducing proposals for the improvement of
    these compounds. In the course of this work you will interact closely with
    medicinal and computational chemists as well as colleagues from other
    disciplines such as screening, pharmacology, pharmacokinetics and
    bioinformatics.
    
    Qualification: The ideal candidate will have a Ph.D. in Chemistry,
    Biochemistry, Biophysics or a related discipline with 3+ years of proven
    experience in protein expression, purification and crystallization.
    Familiarity with computational chemistry techniques such as docking,
    QSAR and ADMET prediction is advantageous. Excellent verbal, written
    and presentation skills along with the ability to work in a dynamic, fast
    paced team environment are mandatory. Special emphasis will be placed
    on your collaborative abilities.
    
    Our offer: The appointment will be for a period of two years.
    Bayer HealthCare offers an attractive salary and benefits. Relocation
    assistance can also be provided where appropriate.
    
    Your application: If you are interested in the above position, please
    apply online, quoting box number 4844 and attaching the relevant
    documents. Please also indicate your salary expectations and the
    earliest possible date on which you could take up employment.
    
    For further details please contact Katrin Homes, Phone: +49 202 36 42 10
    
    Online application: 
    www.mybayerjob.com 
    
    Contact: 
    Mrs. Angelika Buringa 
    Phone: +49 214 30 7 23 81 
    
    


    Postdoctoral Position in Structural Biology / Biochemistry

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    We are looking for a highly motivated Postdoc for our laboratory at the 
    Institute for Physiological Chemistry at Ruhr-University Bochum, Germany. 
    Our work involves biochemical and structural studies on cellular signaling 
    systems with relevance to cancer, metabolic diseases, or aging. A main 
    focus of the group is the mechanism of metabolic sensing and cyclic 
    nucleotide signaling.
    
    Our laboratory is located at the Medical School of the Ruhr-University 
    Bochum which harbours outstanding research groups and facilities. The group 
    is further associated with the Max-Planck-Institute of Molecular Physiology 
    in Dortmund, giving us access to state-of the art x-ray facilities and 
    synchrotron beamlines. Our lab offers excellent research opportunities and 
    a stimulating environment for research in structural biology.
    
    The ideal candidate is a highly motivated Ph.D. with an interest in 
    medically relevant scientific questions and experience in protein 
    biochemistry and protein crystallization. Additional experience in 
    molecular biology would be an asset.
    
    Applications (including CV, research experience, and two names and contact 
    information for references) should be sent to
    Dr. Clemens Steegborn
    Ruhr-University Bochum
    MA 2/141
    Universitaetsstr. 150
    44801 Bochum
    Germany
    Email: Clemens.Steegborn@rub.de
    or 
    Clemens.Steegborn@mpi-dortmund.mpg.de 
    


    Protein Crystallizer with Sanofi-Aventis

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    For the structural biology department with our research center in Vitry (Paris, France) 
    we are seeking
    
    1 group leader in Protein Crystallization well experienced with protein biochemistry, 
    automation, crystallization and database management. You will be involved in the 
    crystallization of pharmaceutical relevant proteins free and complexed with small 
    ligands. In addition you will be developing innovative solubilization protocol of 
    challenging complex systems for successful structural study. You will be responsible 
    for setting up structural biology plans to define the protein constructs that need to 
    be produced for crystallization trials. This position will include the management and 
    coaching of several technical assistants as well as being the primary interface with 
    the protein production team. You will develop and maintain an easy and efficient 
    communication process to keep posted teams from various sites on progress related to 
    their projects. The position is within the structural biology group and requires a 
    Ph.D. in Protein Crystallography with a minimum of 4 years of post-doctoral experience 
    preferably within the pharmaceutical industry. A strong expertise in protein 
    crystallization with a broad knowledge in protein biochemistry including successful 
    experience with automated crystallization workstations is required. Management 
    experience of technical assistants will be a key asset. Demonstrated excellent 
    communication and presentation skills as well as the capacity and enthusiasm for 
    working in a multi-disciplinary multi-site environment are necessary. Excellent 
    knowledge of spoken and written English is an absolute requirement.
    
    
    For further information and application (CV, cover letter and name of two references) 
    please contact 
    M. Mathieu (magali.Mathieu@sanofi-aventis.com) or 
    V. Mikol, (Vincent.mikol@sanofi-aventis.com) 
    Sanofi-Aventis, 13, Quai J. Guesde, BP-14, F-94403 Vitry/Seine, France.
    


    Programmer Analyst Position at UCSD

    Date posted: 14 March, 2006

    Deadline for applications: unknown

    Announcement will be removed: 14 June, 2006

    Full Salary Range: $50,544 - $90,192. 
    Payroll Title: Programmer/Analyst III.
    
    DESCRIPTION:
    Serve as the major software developer on an ambitious project to integrate data 
    traditionally found in biological databases with that traditionally found in the 
    literature to create an exemplar of the next generation medium for the dissemination 
    of scientific knowledge. As a testbed the project will use the Protein Data Bank (PDB), 
    the single worldwide repository for information on the structure of biological 
    macromolecules and the compete corpus of the open access journals published by the 
    Public Library of Science (PLoS).  Specific tasks will include: development of an 
    integrated database of PDB and PLoS content; working on authoring tools as an add-on 
    to Microsoft Word to better capture scientific papers in a database friendly manner; 
    text mining of the literature to find relevant facts; and developing tools for using, 
    querying and visualizing the integrated database content. The successful candidate will 
    have experience in Java, MySQL, text mining and molecular biology. A specialty in 
    structural biology or text mining is considered an advantage.
    
    
    QUALIFICATIONS:
    * Advanced degree in computer science or biology or related scientific field or 
    comparable combination of education and experience with extensive knowledge and 
    research experience with biological application software and data analyses.
    * Strong understanding of the fields of molecular biology, protein structure, 
    bioinformatics and databases.
    * Demonstrated strong programming skills and experience in Java and SQL.
    * Experience with text mining.
    * Demonstrated skills in the development of relational databases.
    * Demonstrated knowledge and experience in web-development (JSP, Java servlet) and 
    web-design programming (Java script, HTML, CSS).
    * Experience in a research-computing environment.
    
    Some travel may be required.
    
    Email a CV and the names and addresses of three references to:
    Prof. Philip E. Bourne
    Dept of Pharmacology
    University of California San Diego
    pbourne@ucsd.edu
    http://www.sdsc.edu/pb
    


    SBNet Latest update at 5 June, 2006.