SBNet - Positions available

NOTE: if you want to announce a job opening, please use this form !

For jobs in crystallography check the lists of the IUCr, ACA, or BCA. The IUCr page also contains links to additional relevant sites. For jobs in NMR, look here or here. Some available postdoc and PhD positions can be found at and at Various job opportunities can be found at the "Career Center" of the Science Advisory Board web site(here).

Note: positions in Scandinavia are shown on a coloured background.

Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

(NKI-AVL and the VU University, Amsterdam, The Netherlands)


Lymphocytes are central in the regulation of immune response. T-lymphocytes differentiate into functionally distinct 
subsets. Proper regulation of the balance between various subsets is crucial for an optimal immune system and for host 
defense against pathogens and cancer. Recently, a new T-cell subset, Th17, which plays a central role in host defense, 
was discovered. In this project, our aim is to identify the underlying regulatory mechanisms and molecular networks that 
govern the formation of Th17 cells.

We will achieve this by generating comprehensive datasets and performing state-of-the art computational modeling based 
on these data. The data sets will include time series RNA and miRNA expression data, siRNA perturbation experiments based 
on kinome and phosphatome libraries, (phospho)protein expression and Chip-Seq data. To construct the computational models, 
we will build both data-driven machine learning models and knowledge-driven (logical and Petri-net) models of the regulatory 
networks. Our aim is to fuse the results of these two approaches to obtain a single, hybrid model. Computational predictions 
of key control mechanisms will be tested experimentally and the resulting data will be employed to refine the models.

The successful candidate will be primarily responsible for constructing models of the regulatory Th17 developmental networks, 
developing new computational methodologies where required and liaising with the computational and biological partners in 
this project.

The Netherlands Cancer Institute is a dedicated cancer center conducting research in all major areas of cancer, with a 
strong emphasis on translational research. The Bioinformatics and Statistics group provides leadership on the collection 
and analysis of data for the research programs of the institute, by developing novel compuational approaches and performing 
state of the art analyses of a wide array of data types, including laboratory and animal experiments, clinical trials, and 
epidemiologic studies.

The Centre for Integrative Bioinformatics (IBIVU) is a broad-based research centre at the VU University that is carried by 
the Faculty of Sciences (FEW) and the Faculty of Earth and Life Sciences (FALW) with strong endorsement from the University 
Board. Its main missions are carrying out a strong and internationally competitive research program in Integrative 
Bioinformatics with an additional focus on Systems Biology, and providing an excellent educational program at bachelor and 
master level; the latter including two-year international master's programmes in Bioinformatics and in Systems Biology.

The vacancy is a research position within the field of bioinformatics/computational biology and the research will be carried 
out in close collaboration with the involved partners. The ideal candidate has a background in bioinformatics, computer 
science, statistics, physics, or biology, strong algorithmic and/or machine learning skills, and experience with the analysis 
of high-throughput data.

The temporary employment will be for a period of three years. The gross monthly salary for a Postdoc will range from € 3140,- 
to € 3.495,- and depends on previous experience. We can help you find housing. The NKI-AVL has been listed in the 
top 25 of 'Best Employers' in 2009 offering a specialized cancer research institute and hospital with good working conditions 
and an excellent atmosphere.

To apply, and for further information please contact Lodewyk Wessels, tel.: +31-20-5127987, e-mail: or 
Jaap Heringa, tel.: +31 20 59 87649 (direct) or +31 20 59 87483 (secr.)

1 July 2010

Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Post-doctoral position in membrane protein structural biology
    with  NMR at the Biozentrum of the University Basel, Switzerland

A post-doctoral position is available in the group of Sebastian Hiller at
the Biozentrum of the University Basel, starting August 1, 2010. We study
the structure and function of integral membrane proteins and their complexes
with NMR. Our projects address fundamental biological processes of high
impact. A representative example for our research is the human
voltage-dependent anion channel (VDAC) (1,2).

The postdoctoral research project concerns the *de novo* structure
determination of a membrane protein complex involved in substrate transport
across membranes. We will establish the sample preparation using native-like
membrane mimics and determine the structure to atomic resolution using
solution and solid-state NMR. Subsequently, the functioning of the protein
complex and its interactions with ligands are characterized. An integral
part of our projects is the use and development of state-of-the-art
biochemical and NMR techniques (3). Interested candidates need a Ph.D. in
Biochemistry, Biophysics, Structural or Molecular Biology or related fields.
Expertise in at least one of the following areas is mandatory: NMR, protein
biochemistry, membrane proteins, molecular biology. The successful candidate
is highly motivated, creative and capable of contributing productively in a
team environment. Communication skills in oral and written English are

The position and the research projects are long-term funded by the Swiss
National Science Foundation (SNSF). We offer an exciting and enthusiastic
work environment with scientific collaborations in the institute and
worldwide. The Biozentrum Basel is one of the leading biomedical research
institutions in Switzerland and has recently been placed among the Top 10
international ?Best Places to Work for Postdocs? by *The
Scientist*magazine. Facilities for structural biology include 600 MHz
and 800 MHz
Bruker spectrometers equipped with cryogenic and magic angle spinning
probes. Salary and benefits are attractive, following the guidelines of the
Swiss National Science Foundation. The start date is August 1, 2010 or on
mutual agreement.

Applications and informal queries about the lab and research projects should
be directed by email to Sebastian Hiller. Applications should include a
cover letter summarizing current and future research interests, a CV, list
of publications and contact information for at least two references.

Prof. Sebastian Hiller
Biozentrum, University of Basel
Klingelbergstrasse 50/70
4056 Basel, Switzerland

Phone:   +41 44 633 43 45
Fax:       +41 44 632 16 21


   1. *Hiller S*, Garces RG, Malia TJ, Orekhov VY, Colombini M and Wagner G.
   Solution structure of the integral human membrane protein VDAC-1 in
   detergent micelles. *Science* *321*, 1206?1210 (2008).
   2. Raschle T, *Hiller S*, Yu TY, Rice AJ, Walz T and Wagner G. Structural
   and functional characterization of the integral membrane protein VDAC-1 in
   lipid bilayer nanodiscs. *J. Am. Chem. Soc.* *131*, 17777?17779 (2009).
   3. *Hiller S*, Ibraghimov I, Wagner G and Orekhov VY. Coupled
   decomposition of four-dimensional NOESY spectra. *J. Am. Chem. Soc.* *131
   *, 12970?12978 (2009).

Senior Director

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Senior Director, Structural Biology (Takeda San Diego)


Directs, develops and integrates the Company's Structural Biology
resources to ensure timely achievement of major goals. Oversees and
provides direction for the Molecular Biology, Crystallography, and
Protein Chemistry sub-groups.  Provides deep expertise and strategic
leadership in X-ray crystallography, and across structure based drug
design programs in oncology, inflammation and metabolic diseases.
Invents and advances drug candidate compounds towards preclinical and
clinical development.


*    Directs the management and research activities of TSD Structural Biology departments 
to enhance the Company's IND success rates, particularly in the oncology, inflammation, 
and metabolic diseases therapeutic areas..
*    Acts as a thought leader in crystallography and structure-based
drug design
*    Co-leads TSD cross-functional drug discovery programs to achieve
compelling target product profiles based on scientific, clinical,
regulatory, and commercial rationales
*    Plays an integral role in TSD drug discovery target selection
and portfolio management both as a member of the TSD Research Committee
and in inter-site Takeda forums in the US and Japan.
*    Sets annual site-level and multi-year strategic plans, and
engages in international corporate strategic planning to fulfill TSD's
mission as a Takeda IND engine.
*    Directs and controls the activities of one or more
functional/technical areas including Molecular Biology, Crystallography,
& Protein Chemistry.  Responsible for the direct line management of the
department team leaders (up to Director level), and for their research
and career development
*    Effectively communications multiple dimensions of Company's
science and business strategies and establishes productive relationships
with outside groups, including major collaborations.
*    Collaborates with senior management to manage company operations
and set company-wide policies
*    Budgetary responsibility for functional areas.  Summarizes and
presents R&D project status, budget, and issues/highlights to senior
management and project leaders/teams.  Ensures budget requirements are
*    Teaches, advises, and leads direct and indirect reports in an
inspirational fashion, to accomplish key group and corporate objectives


    *    Ph.D. in crystallography, or a related discipline, and a
minimum of 12 years industry experience; OR
    *    MS in chemistry, or related discipline and a minimum of
14 years of industry experience; OR
    *    BS in chemistry, or related discipline and a minimum of
17 years of industry experience
    *    Recognized internationally as an expert in
crystallography and structure-based drug design
    *    Track-record of expertise in X-ray crystallography of
soluble and membrane-associated proteins and in using crystallographic
data to invent potential novel medicines
    *    Inspirational leadership skills with proven experience
in successfully managing large projects and maximizing the performance
of large groups of scientists
    *    Track-record of expertise in structure based drug
discovery, including biochemistry, biology,  efficacy and
Pharmacodynamic/biomarker models, and toxicology
    *    Extensive knowledge of current drug discovery &
development processes worldwide with an emphasis on oncology,
inflammation and metabolic disease areas
    *    Clear record of accomplishment (e.g. publications,
patents, presentations) including evidence of leadership in delivering
one or more internally discovered compounds into clinical development
    *    Exceptional interpersonal, collaborative and
team-building skills
    *    Outstanding written and oral communication skills


    *    Potential exposure to hazardous/toxic/dangerous
    *    Manual/physical dexterity required to operate basic
office equipment (i.e. computers, printers, phones, photocopiers, etc.),
and carrying, handling and reaching for objects.
    *    Prolonged standing and/or sitting.


    *    Ability to drive or fly to various meetings or client
sites, including overnight trips.
    *    International travel required, including some weekends
    *    Requires approximately 15 % travel.

    Submit your resume and start a quality career with Takeda!

    We are an equal opportunity employer. 

    No Phone Calls or Recruiters Please.

Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: 31 May, 2010

Announcement will be removed: 1 June, 2010

Senior lectureship in Protein Bioinformatics at Link?ping

announces a position as
Senior Lecturer in Protein Bioinformatics

formally based at Institutionen för fysik, kemi och biologi

The position has a focus on eScience method development.

Bioinformatics is a young but rapidly developing research field with important
contributions to all life sciences. Linköping University has since several years
expanded in the areas of life science technologies, and thanks to the long
tradition of interdisciplinary projects, there are much collaboration between
different departments. At Linköping University, there are several
internationally well-known bioinformatics research groups. The present
recruitment should strengthen the bioinformatics activities with emphasis on
developments of new methods and strategies for analysis of large-scale
biological data. Furthermore, multi-disciplinary collaboration will be of
great importance. Also close collaboration with the National Supercomputer
Centre (NSC) at Linköping University is foreseen. Key future challenges include
new ways to use distributed computing for large-scale analysis and to combine
and integrate data from various sources in a high-throughput manner.

The new position is part of the Swedish Government's Strategic Research Area
(SRA)for eScience, in particular the Swedish eScience Research Centre (SeRC)
jointly established by Linköping University and the three universities in
Stockholm (Royal Institute of Technology, Stockholm University and Karolinska
Institutet). SeRC aims to strengthen eScience research in core areas
(distributed resources and database technology, parallel algorithms and
performance optimisation, mathematical modelling, numerical analysis,
interaction and visualisation), and to do so in tight collaboration with a set
of eScience communities and the largest high-performance computing facilities of

The successful candidate will have a special responsibility for developing the
SeRC bioinformatics community and form new interactions both with relevant
departments at Linköping University and relevant groups within SeRC.
Furthermore, multidisciplinary collaboration will be of great importance.

This appointment as Senior lecturer involves research, teaching, and
administrative duties. It is also the responsibility of the holder of the
appointment to follow development within one's own research area as well as
societal developments that are of relevance to the research and teaching. The
holder of the appointment as Senior lecturer shall mainly conduct research but
also participate in teaching on the undergraduate and advanced levels at
Linköping University.

The position requires a doctorate or equivalent scientific qualifications of
relevance to the subject of the appointment and the duties involved. The
position also requires that the holder has a degree in teaching in higher
education or has acquired equivalent skills in some other way, and has shown
pedagogical skills.

Grounds for assessment
The grounds for assessment for the appointment as Senior lecturer are the extent
of proficiency in the research area and the extent of administrative and other
skills relevant to the subject of the appointment and the duties involved.

The extent of proficiency in developing and leading university operations and
staff, as well as the ability to collaborate with the surrounding society and
inform about research and development, will also be considered.

In the assessment for this position equal importance is attached to scientific
and pedagogical/administrative proficiency. The applicant should have high
interpersonal skills and excellent ability to communicate with colleagues and users.

Scientific proficiency shall be proven with own research as well as with
research planning and leadership. Moreover, scientific proficiency can be proven
through ability to achieve research results in collaboration with other teachers
and through ability to inform about research.

Pedagogical skills can be demonstrated through broad and solid knowledge in the
subject of the appointment. Pedagogical skills shall also be proven through the
ability to propagate commitment and interest for the subject, the ability to
structure and organize knowledge mass for courses, the ability to motivate
students for own learning, the ability to communicate with students and other
teachers, as well as the ability to innovate.

Administrative skills shall be proven with experience of developing and leading
operations and staff.

Equal opportunities
Linkoping University shall continue to develop as an attractive and creative
work place characterized by equal opportunities, and therefore works actively to
promote diversity and gender equality.

A majority of the Senior lecturers within the department are men, which is why
precedence will be given to women in cases where qualifications are deemed
otherwise equivalent.

Appointing procedure
The appointment will be made by the Vice-Chancellor of the University on the
advice of the Appointment Advisory Board.

Starting date
By agreement.

The University applies individual salary scales adapted to the experience of the
employee and to the labour market. Please specify salary level in your application.

Further information
Professor Bengt Persson, tel +46(0)13-28 29 83( The union
representatives are Mr. Örjan Lännevik (SACO), tel +46(0)13-28 66
34,(, and Mr. Gabriel Thott (OFR/S), tel +46(0)11-36 31 71,
( Secretary of the Appointments Advisory Board, Mr.
Lars Alm, tel +46 (0)13-28 10 12 (, will answer any questions
about the application procedure.

Application procedure
Your application marked with the Registration number LiU-2010-00630, accompanied
by your Curriculum Vitae (please use the template,
list of publications, and all other documents you may wish to refer to, must
reach the University Registrar no later than 2010-05-31 at the following
addresses: e-mail: or Linköpings Universitet Registrator,
SE-581 83 Linköping, SWEDEN.
Scientific work shall be sent in three printed copies.

Documents that are sent electronically (application, CV, and list of
publications) shall be in MS Word or pdf.

Late applications will not be considered.

Announcement in English:

Annons pä svenska:

Senior Scientist position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Senior Scientist, Membrane Protein Chemistry
(Takeda San Diego)

Job Number: 1000059

Ph.D. in life science with thesis, publication(s) and minimum 5 years of
relevant experience in membrane protein chemistry, OR

- MS in life science with minimum 11+ years of relevant experience, OR

- BS in life science with minimum 14+ years of relevant experience

- Proven track record in membrane protein structural biology with >5 years 
of expert knowledge and hands-on experience in successful
expression, purification, bioanalytical and biochemical characterization
of membrane proteins using state-of-the art technologies

Principal Scientist Membrane Protein Chemistry
(Takeda San Diego)

Job Number: 1000057

*    Ph.D. in life science with thesis, publication(s), and minimum
of 8years of relevant experience in membrane protein chemistry OR
*    MS in life science with minimum 14+ years of relevant membrane
protein chemistry experience, OR
*    BS in life science with minimum17+ years of relevant membrane
protein chemistry/structural biology experience
*    Proven leadership in membrane protein structural biology with a
track record with > 5years of expert knowledge and hands-on experience
in successful expression, purification, preferably crystallization,
bioanalytical and biochemical characterization of membrane proteins
using state-of-the art technologies

Senior lectureship in Bioinformatics at Stockholm University

Date posted: 23 April, 2010

Deadline for applications: 31 May, 2010

Announcement will be removed: 1 June, 2010

University Lecturer in Bioinformatics

within the Department of Biochemistry and Biophysics (DBB) or the department
of computer science (NADA) (ref nr SU 612-0755-10). Deadline for
application: May 31 2010. * Swedish 'universitetslektor'; approximately
equivalent to Senior Lecturer (UK) or Associate Professor (US)

NADA is one of Sweden?s most advanced and successful research and education
institutions in Information Technology. One strong research area at NADA is
computational biolopgy. Together with DBB it is in charge of Stockholm
Bioinformatics Center . DBB is one of the largest
departments at Stockholm University. It has a strong focus on research in
biochemistry, biophysics and bioinformatics. In addition to Stockholm
Bioinformatics Center it also hosts the Center for Biomembrane
Researchand is responsible for the
bioinformatics at Science
for Life Laboratory  .

*Subject description:* Bioinformatics, e-science
*Main tasks:* Research, teaching and supervision. Some administrative
responsibility within SeRC (Swedish e-Science Research Center).

*Required qualifications:* To qualify for employment as a university
lecturer the applicant should have been awarded a PhD or have equivalent
scientific competence, completed a course in university pedagogy of at least
7,5 credits or acquired similar knowledge** in another way, and demonstrated
teaching proficiency.

The applicant must have the ability to collaborate as well as the competence
and qualities needed to carry out the employment tasks successfully.

**Applicants who have not yet completed a course in university pedagogy can
be offered a temporary position (1+1 year) in order to obtain such

*Assessment criteria:* In the appointment process equal and special weight
will be given to scientific and teaching proficiency.

Weight will also be given to administrative proficiency and proficiency in
developing and leading an organisation.

The following should be considered as a special merit:
? documented experience of developing methods in bioinformatics.

*Additional information:* Since most university lecturers at the department
are men, applications from women are particularly welcome.

The position is part of SeRC, placed at an institution after agreement. The
Department of Numerical Analysis and Computer Science, NADA, and the
Department of Biochemistry and Biophysics, DBB, both have promised to accept
suitable candidates.
An important role of the holder of this position is to participate in the
bioinformatics community within the strategic initiative in e-science,
?Swedish e-Science Research Center? (SeRC). The lecturer is expected to
initiate collaborations between SeRC and other research areas of SeRC.

Applicants may request appointment at the rank of professor; if so this must
be stated clearly in the application. In order to qualify for promotion to
professor the applicant must have demonstrated well-documented scientific
proficiency at a high international level, and well-documented teaching

*Further information about the position* can be obtained from:
Prof. Arne Elofsson, e-mail: , phone +46(0)70 695 10 45 or
Prof. Jens Lagergren, e-mail: , phone +46 (0)8 55 37 85 70

Administrative coordinator Katarina Gustafsson, telephone +46 (0)8 16 22 92,
e-mail: will provide further information
about the application and appointment procedure if required.

*Trade union representatives:* Bo Ekengren, (SACO), Lisbeth H?ggberg
(Fackf?rbundet ST), telephone +46 (0)8 16 20 00 (switchboard) och Gunnar
Stenberg (SEKO) +46 (0)70-316 43 41.

*Guidelines for the application* are given in the Template for application
for employment and for promotion to the rank of professor or senior lecturer
at Stockholm University. The template and other relevant documents including
Rules of Employment for the hiring of Teachers can be downloaded from or be provided by the administrative coordinator. It
is the responsibility of the applicant to ensure that the application
follows the template and that it is submitted before application deadline.

In order to apply for this position please use our web-based application
form. Application form for this

*Further information;*
Stockholm University:
Templates and rules regarding employment:
The Department of Biochemistry and Biophysics:
The Department of Numerical Analysis and Computer Science:

*You are welcome to submit your application, quoting ref no SU 612-0755-10,
no later than May 31, 2010*


Engelsk annons se

Svensk annons se

A postdoc position at OpenEye Scientific Software, Inc, Santa Fe, NM USA

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Applications are invited for a postdoctoral position at OpenEye Scientific Software, Inc. to work on structural assessment 
and re-refinement of a large number of protein-ligand complex structures from a number of pharmaceutical companies to be 
deposited with the Community Structure-Activity Resource (CSAR) and the PDB.
We seek a highly motivated Ph.D. with extensive experience in protein structure determination by X-ray crystallography to 
work in our Santa Fe, NM office. Experience with structure determination and interpretation are essential.  Familiarity with 
protein-small molecule complex structures, refmac, phenix.refine and python are beneficial.
Applicants must have a Ph.D. and fewer than 2 years of postdoctoral experience.

This is s full time position of fixed term for two (2) years.  A 401k plan, medical & dental benefits, and profit sharing 
are all part of our standard compensation package. OpenEye Scientific Software Inc. is an Equal Opportunity Employer.

Qualified individuals should submit a resume and cover letter along with the contact information for three references via 
e-mail to Please reference job code Structural Biology Position.

HR: Structural Biology Position
OpenEye Scientific Software, Inc.
9 Bisbee Court, Suite D
Santa Fe, NM 87508 

Research Associate position available

Date posted: 23 April, 2010

Deadline for applications: 1 June, 2010

Announcement will be removed: 2 June, 2010

Research Associate in X-ray Protein Crystallography of Light Induced Reactions at Imperial College London

Job Title Research Associate in X-ray Protein Crystallography of Light Induced Reactions

Department/Division/Faculty Division of Molecular Biosciences, Faculty of Natural Sciences
South Kensington Campus, London SW7 2AZ

Closing Date 1 June 2010 (midnight GMT/BST)
Fixed term for 24 months

Applications are invited for a Research Associate position in the Division of Molecular Biosciences in the field of 
time resolved Laue X-ray crystallography of light sensitive proteins in the group of Dr. Jasper van Thor. The successful 
candidate will develop and employ experiments for time resolved X-ray diffraction using the pink-Laue technique at 
specialised beam line stations that combine pulsed broadband hard X-rays with pulsed optical excitation, at the SLS, APS 
and ESRF. The post will be based at Imperial College London, South Kensington campus

The work will be conducted in a multidisciplinary environment which includes facilities for ultrafast electronic and 
vibrational spectroscopies to support the optical control of photolysis and reaction initiation in macromolecular crystals.

The research deals with the light induced reactions in photoreceptors and fluorescent proteins and will focus on 
crystallisation of existing and new targets, analysis and optimisation of Laue diffraction, data processing and structure 
calculation of sub-ns intermediates. The van Thor group also provides support for ultrafast spectroscopic investigation of 
light induced reactions in targets. You will be required to work with members of the team on spectroscopic characterisation 
and photolysis control.

You will have a PhD in Biochemistry, Chemistry, or Physics or the equivalent professional qualifications and experience with 
a track record in Structural Biology. Extensive experience in X-ray protein crystallography using synchrotron sources as well 
as experience with data processing and structure calculation of macromolecules are essential.

You will also have experience in crystallographic data processing and structure calculation. Experience in biomolecular 
spectroscopy would be an advantage. Experience with molecular biology, protein purification and crystallisation will be 

Our preferred method of application is online via this website. Please download the following application form and save 
to your computer. Once completed, please upload your application form prior to submitting your application.

Please enter job ID NS2010070AB into the College recruiting webpages

or directly

Should you have any queries please contact:

Dr Jasper van Thor - 

Faculty Job Posting

Date posted: 23 April, 2010

Deadline for applications: 1 September, 2010

Announcement will be removed: 2 September, 2010

Applications are being accepted for a tenure track position at the Assistant or Associate Professor level in the Department 
of Biology, Faculty of Science,  University of Waterloo. Applicants should have a PhD and postdoctoral experience with a 
research record in Macromolecular X-ray Crystallography. Duties of the position include establishment of an independent 
research program, teaching and supervision at the undergraduate and graduate levels, and participation in the running of the 
Department and University. The University has instrumentation for macromolecular crystallography, including a Rigaku 
Micromax/R-Axis 4++ diffractometer system. Inquiries and applications, consisting of a full curriculum vitae with publication 
record, statement of research interest and teaching experience, and names of three references, should be sent electronically 
to David R. Rose, Chair, Department of Biology, University of Waterloo, c/o Gini Kennings, The closing 
date for applications will be September 1, 2010, with a starting date on or after January 1, 2011. All qualified candidates 
are encouraged to apply; however Canadians and permanent residents will be given priority. The University of Waterloo 
encourages applications from all qualified individuals, including women, members of visible minorities, native peoples, and 
persons with disabilities


Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Post-doctoral position: Structural Biology of Cytokine-Receptor

A Post-doctoral position is available immediately to study the structure
and function of cytokine receptor complexes that play essential roles in
the development and control of the adaptive immune response. The
inter-cellular communication provided by these molecules is controlled
by a dazzling array of protein-protein interactions that our lab is
unraveling. We also study the structure and function of virally encoded
proteins produced by herpes and poxviruses that target the IL-10 family
and allow the viruses to escape elimination by the immune system.
Understanding the competing molecular strategies used by the host and
virus to activate or deactivate the immune system may to lead novel ways
of controlling chronic inflammation and/or improving the detection and
elimination of persistent viral infections. The lab performs the
techniques required to answer mechanistic questions about molecular
recognition, viral immune evasion, and cell signaling including protein
biochemistry, X-ray crystallography, surface plasmon resonance,
isothermal titration calorimetry, computational and bioinformatic
approaches, and structure-based functional assays in cells.

Applicants are expected to be proficient in molecular
biology, protein expression (multiple systems is a benefit), and protein
purification methodologies.   Experience in X-ray crystallography, or
other structural or biophysical science (e.g. NMR, SAXS, etc), is a
plus.  Interested applicants should send a CV, statement of research
interests, and list of references to:

Dr. Mark R. Walter
Department of Microbiology
University of Alabama at Birmingham (UAB)
1025 18th Street South
Birmingham, AL 35243 

Scientific Programmer Position at the Nucleic Acid Database

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Scientific Programmer Position at the Nucleic Acid Database

The Nucleic Acid Database project at Rutgers University is seeking
candidates for a scientific programmer position to support development
of new tools and database services for macromolecular structure

An ideal candidate should have an advanced degree in structural biology
or computational chemistry and strong programming skills. Demonstrated
experience with the following is highly desirable: proficiency in
programming languages C++,and Python, design and development of large
software application systems; webuser interface development using Java,
web service development using SOAP and REST; database application
development using JDBC and MySQL.

The position holder should be able collaborate with broad, multidisciplinary
teams. Excellent written and verbal communication skills are essential.

Please respond to:

Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Postdoctoral position in protein crystallography at Emory University

A postdoctoral position is available in the Department of Biochemistry at Emory University (Atlanta, GA). This position has 
been funded for two years to support an NIH R01 grant aimed at understanding the structural and mechanistic basis for the 
evolution of novel function within the steroid hormone receptors.

For publications resulting from this work see:
Ortlund et al, Science. 2007 Sep 14;317(5844).
Bridgham et al, Nature. 2009 Sep 24;461(7263):515-9.

The successful candidate will have a very strong background in X-ray crystallography, molecular biology and biochemistry, 
along with good organizational, communication and interpersonal skills.  Emory University maintains a state-of-the-art in 
house X-ray diffraction system and has regular synchrotron access.

Please send (email) cover letter, CV and the names and address of three references to:

Eric Ortlund, Ph.D.
Assistant Professor
Department of Biochemistry
Emory University School of Medicine
1510 Clifton Road, NE, Room G235
Atlanta, GA  30322
Tel 404-727-5014  Fax  404-727-2738

PhD fellowship University of Copenhagen

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

PhD fellowship University of Copenhagen: Nicotinic acetylcholine alpha4beta2 receptor model systems

General announcement and how to apply:

Project description:

Deadline for applications: Monday 3 May 2010 at 12 o'clock noon

About the group:

Please contact me if you wish further information.
Best regards
Michael Gajhede 

Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Postdoctoral position at the Curie Institute for a protein crystallographer

A post-doctoral position is available in the "Structural Motility" Team
directed by Dr. Anne Houdusse at the Curie Institute, Paris, France.

Our research project includes structural studies of molecular motors in
close collaboration with functional studies.

Our goal is to understand how these motors function, are regulated and
recruited by specific partners in the cell.

Myosins are molecular motors that convert chemical energy into mechanical
energy. The structures for a number of states for two unconventional motors
myosin V and myosin VI have been obtained in the laboratory. Since myosin V
and VI move in opposite direction along actin filaments, we have also
described the structural elements that are essential for determining the
directionality of these molecular motors. Other members of the family also
adopt atypical motility will be the focus of future studies in the
laboratory. Our structural studies on myosin motors have opened the door to
new experiments that directly aim at understanding how force is produced in
the motor and we are looking for a trained crystallographer to perform a
number of structural studies using innovative approaches.

Publications :

Ménétrey, J., et al. 2005. Nature (London) 435:779-85.

Ménétrey, J., et al. 2007.  Cell 131:300-308.

Ménétrey, J., et al. 2008. EMBO J. 27:244-52.

Mukherjea M, et al. Molecular Cell, 5:305-15.

To apply, you must have a Ph.D. in protein x-ray crystallography; and be
highly experienced in protein crystallization, protein and crystal handling,
data collection using synchrotron and structure determination and
refinement. Excellent oral and written communication skills are a

Interested candidates should send a CV and three letters of recommandation
at Anne Houdusse (

Dr. Anne Houdusse
Group Leader for the Structural Motility team
Directeur de Recherche CNRS - UMR 144 du CNRS
INSTITUT CURIE - Section de recherche
26, rue d'ULM
75248 Paris cedex 05
Tel: 33- 1- 56-24-63-95    Fax: 33- 1- 56-24-63-19

Ph.D. Positions in Evolutionary Bioinformatics

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

Positions are currently available for Ph.D. students in evolutionary
bioinformatics in the Liberles Research Group at University of Wyoming.
Applicants should have had coursework and/or practical experience
programming in C++ and/or a scripting language (e.g. Perl) and relevant
coursework in calculus, statistics, molecular biology, biochemistry,
genetics, as well as an interest and coursework in evolution. The
Liberles Group works in comparative genomics, and mechanistic molecular
evolution, addressing (for example) how protein structure and population
genetics interplay to govern protein sequence evolution. For more
details on research in the Liberles Research Group, please see

University of Wyoming is located in Laramie, WY, 2 hours north of Denver
in the rocky mountains. It is an ideal location for those with interests
in skiing (both downhill and cross country), rock climbing, hiking, ....

To apply, please send a CV, statement of research interests, and contact
information for three references, to An M.S. degree
OR GRE scores are required as well. Please indicate your experience with
topics in computer science, math/stats, and biology/biochemistry as
indicated above in your cover letter. Informal inquiries before
application are welcome. 

Postdoctoral position available

Date posted: 23 April, 2010

Deadline for applications: unknown

Announcement will be removed: 23 June, 2010

The Scripps Research Institute
Palm Beach Co, Florida

Post-doctoral Position:
Nuclear Receptor Signaling and Structure-Based Drug Design

The Scripps Research Institute has established a major science center in
Palm Beach County, Florida, focusing on biomedical research, technology
development and drug design.

A post-doctoral fellowship position is available to study nuclear receptor
signaling and structure based drug design in the laboratory of Associate
Professor Kendall Nettles.

Candidates should have a PhD degree and experience in protein
crystallography and/or a good background in molecular biology and protein
biochemistry. The laboratory is equipped with robots for high throughput
cloning, protein purification, solution mixing and crystallization, and
automated crystal visualization. The institute has a home source,
and dedicated time at SSRL and APS.

We use a variety of structural and molecular approaches to understand the
connections between small molecule ligand, receptor structure and function,
and endocrine physiology. Ongoing projects include investigation of the
structural basis for tissue and pathway specific signaling through the
estrogen and glucocorticoid receptors, signal transduction across the RXR
heterodimer interface, and structure-based drug design. The fellow will
interact closely with the Drug Discovery, Advanced Technology, and Genomics
groups at Scripps Florida to take advantage of other automated technologies,
including robots for small molecule screening and transfection.

Please send curriculum vitae, a brief statement describing research
experience and scientific interests and the names of at least two references

Kendall W. Nettles, PhD
Associate Professor, Department of Cancer Biology
The Scripps Research Institute
130 Scripps Way
Jupiter Fl 33458


RIKEN recruits Foreign Postdoctoral Researcher (FPR)

Date posted: 23 April, 2010

Deadline for applications: 28 May, 2010

Announcement will be removed: 29 May, 2010

This is to notify that RIKEN is now accepting applications for Foreign Postdoctoral Researcher (FPR) positions for  fiscal 
year 2011. These positions are for foreign young scientists who have demonstrated creative and innovative ideas and who can 
be expected to achieve broad international recognition in the future.

To recruit top class researchers from overseas, we would like to ask for your help. If you have any chance to introduce 
this program outside RIKEN, it would be highly appreciated.

Applicants to Host Laboratory: May 28, 2010
Host Laboratory to Reseach Personnel Section:June 11, 2010

For more information, please go to the website below. (English)

Thank you for your help in advance.

FPR Desk

Foreign Postdoctoral Researcher Desk (Ms. Shimizu)
Global Relations Office, RIKEN
2-1 Hirosawa, Wako, Saitama 351-0198

Fax: 048-463-3687

SBNet Latest update at 21 May, 2010.