SBNet - Structure-assisted Drug Design course

13-16 June 2000, Stockholm

The course will give an overview of the drug design process by a combination of lectures on the various aspects of the design process and computer-based practicals. The course is primarily intented for PhD students and post-doctoral fellows within SBnet, but applications from students and post-docs from outside the programme are welcome. The course is limited to 20 participants. For accepted participants from outside the Stockholm-Uppsala region, expenses for travel will be covered and accomodation (double rooms) will be arranged.

The lectures will be open to any and all interested !

Course organizers:

The course will take place at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm from Tuesday, June 13 to Friday, June 16. Applications should be sent to Gunter Schneider, Department of Medical Biochemical & Biophysics, Karolinska Institutet, 171 77 Stockholm by mail or e-mail ( no later than April 20 and should include a cv and a short statement why you wish to attend the course.

Course schedule

Tuesday, June 13
Overview of the drug discovery process Jan Hoflack, AstraZeneca
Target identification Staffan Lake, P&U
Bioinformatics and drug design Per Kraulis, P&U
Structural genomics Janet Newman, Structural Genomix
Practical: Searching for target motifs. Sequence searching, classification of protein families and alignment Martin Norin, Web based tools, held at KI
Evening lecture: Success story I Roger Crossley, P&U

Wednesday, June 14
Target validation - assay development Johan Häggblad, P&U
Target validation - transgenic model systems Håkan Wennbo, AstraZeneca
Target validation - modelling Martin Norin, P&U
Practicals: Protein modelling. Continuation of practical from previous day Martin Norin
Evening lecture: Success story II Ch. Oefner, Roche

Thursday, June 15
High throughput screening I Mark Divers, AstraZeneca
High throughput screening II Johan Häggblad, P&U
Directed combinatorial libraries Mats Kihlén, P&U
Hit to lead Simon Teague, AstraZeneca
Practicals: Searching for new ligands. (Data-mining using ISIS. Docking with ICM. 3D graphics room session. Held at P&U Hornsberg) Mats Kihlén
Evening lecture: Success story III Cristopher Lepre, Vertex

Friday, June 16
Lead optimization Simon Teague, AstraZeneca
Pharmakokinetics Ingrid Påhlman, AstraZeneca
Candidate drugs, phase I, II, and III trials, strategies Johan Kördel, P&U
Study visit P&U

SBNet Latest update at 24 March, 2000.