The course will give an overview of the drug design process by a combination of lectures on the various aspects of the design process and computer-based practicals. The course is primarily intented for PhD students and post-doctoral fellows within SBnet, but applications from students and post-docs from outside the programme are welcome. The course is limited to 20 participants. For accepted participants from outside the Stockholm-Uppsala region, expenses for travel will be covered and accomodation (double rooms) will be arranged.
The lectures will be open to any and all interested !
The course will take place at the Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm from Tuesday, June 13 to Friday, June 16. Applications should be sent to Gunter Schneider, Department of Medical Biochemical & Biophysics, Karolinska Institutet, 171 77 Stockholm by mail or e-mail (email@example.com) no later than April 20 and should include a cv and a short statement why you wish to attend the course.
|Overview of the drug discovery process||Jan Hoflack, AstraZeneca|
|Target identification||Staffan Lake, P&U|
|Bioinformatics and drug design||Per Kraulis, P&U|
|Structural genomics||Janet Newman, Structural Genomix|
|Practical: Searching for target motifs. Sequence searching, classification of protein families and alignment||Martin Norin, Web based tools, held at KI|
|Evening lecture: Success story I||Roger Crossley, P&U|
|Target validation - assay development||Johan Häggblad, P&U|
|Target validation - transgenic model systems||Håkan Wennbo, AstraZeneca|
|Target validation - modelling||Martin Norin, P&U|
|Practicals: Protein modelling. Continuation of practical from previous day||Martin Norin|
|Evening lecture: Success story II||Ch. Oefner, Roche|
|High throughput screening I||Mark Divers, AstraZeneca|
|High throughput screening II||Johan Häggblad, P&U|
|Directed combinatorial libraries||Mats Kihlén, P&U|
|Hit to lead||Simon Teague, AstraZeneca|
|Practicals: Searching for new ligands. (Data-mining using ISIS. Docking with ICM. 3D graphics room session. Held at P&U Hornsberg)||Mats Kihlén|
|Evening lecture: Success story III||Cristopher Lepre, Vertex|
|Lead optimization||Simon Teague, AstraZeneca|
|Pharmakokinetics||Ingrid Påhlman, AstraZeneca|
|Candidate drugs, phase I, II, and III trials, strategies||Johan Kördel, P&U|
|Study visit P&U|