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Structure Biology News

March 2010

BEAMTIME ON THE ESRF Bio-SAXS BEAMLINE ID14-3

The Bio-SAXS beamline at ID14-3 at the ESRF ( http://www.esrf.fr/UsersAndScience/Experiments/MX/About_our_beamlines/ID14-3 ) has now been in operation for over a year.
Robotic sample loading is available on the beamline using a device constructed in a collaboration between the EMBL (Grenoble and Hamburg outstations) and the ESRF. Automated data analysis is also implemented following the model of the SAXS facility at X-33, EMBL Hamburg (processing and preliminary analysis).

The end-station can rapidly provide Users with standard data concerning the size (radius of gyration, maximum dimension and volume) and molecular weight of samples and allow on-the fly / /ab-inito// shape reconstruction in order to provide feedback enabling the data collection strategies to be optimized. Access to this Bio-SAXS facility for SANS users (small angle neutron scattering at the Institute Laue- Langevin) just after their neutron experiment is possible if required. The procedure is to first apply for the SANS experiment, specifying that access to ESRF beamtime is also requested. The ILL will then indicate if an ESRF rolling proposal is to be completed. First Users using both facilities are expected this summer. The complementary information provided by neutron scattering (i.e. contrast variation) and X-ray scattering can be obtained in a single visit to the Grenoble site.

Application for beam-time on ID14-3 can be made via the rolling access mechanism at ANY time. Those who wish to apply should use the mechanism at:
http://www.esrf.fr/UsersAndScience/UserGuide/Applying/ProposalGuidelines/MXnon-BAGproposal

where it must be clearly indicated in the title of the proposal that the application is for Bio-SAXS beamtime on ID14-3. Please note that BAG members should also continue to apply using the rolling mechanism. However, in the next proposal round (September 2010) BAGs will also be able to apply through the BAG system.
[Added 5 March 2010]


MAX-lab beamtime Deadline March 12th 2010

CALL FOR PROPOSALS for beam time at MAX-lab, Lund, Sweden.

Researchers using synchrotron radiation are invited to submit proposals for beam time for experiments to be carried out during the time period July 2010 to June 2011.
The available facilities include beamlines for MX and SAXS, see below.
Please note that the tunable station I911-3 will be upgraded during 2010 with a completely new experimental set-up including a EMBL/ESRF microdiffractometer and a CATS sample changing robot.
Information on how to prepare and submit proposals as well as descriptions of the other experimental facilities available at MAX-lab can be found at http://www.maxlab.lu.se
It is also possible to apply for Fast Access MX beam time at any time though it is recommended to submit normal proposals if possible. br> It is not possible to submit block allocation proposals for MX this year (ie all groups with block allocations do not need to resubmit this year).
*** The proposal deadline is March 12th, 2010 ***


[Added 1 March 2010]


December 2009

Call for Beamline 2010 at EMBL Hamburg

Call for access to Synchrotron Beamline Facilities 2010

EMBL Hamburg, Germany

We announce a call for synchrotron beam time applications in biological
small-angle scattering (SAXS) and X-ray crystallography (PX). Up to 32
weeks of beam time will be available at the DORIS storage ring (DESY)
from March 2010 to February 2011.

EMBL Hamburg will operate the following beamlines:

Beamline, New features, Scientist responsible
X33, (SAXS) Automated and remote operation, Dmitri Svergun
X11, (PX) MAR555 Flat Panel detector, Santosh Panjikar
X12, (PX) MAD, S-SAD, fluorescence analysis, Andrea Schmidt
X13, (PX) Microspec, expert data collection, Matthew Groves

The deadline for submission of proposals is January 13, 2010.
An external Priorities Committee will assess the proposals.

Electronic beam proposal forms and a detailed description of the
beamline facilities are available at www.embl-hamburg.de
(click on 'Access to Infrastructures').

Additional EMBL services can be found at www.embl-hamburg.de/facilities

EMBL is constructing three new beamlines for applications in biological
X-ray crystallography (PX) and small-angle scattering (SAXS) at the Petra-III
synchrotron storage ring, which are scheduled to be available from 2011.
See www.embl-hamburg.de/services/petra for further information.

For further information
tel. +49-40-89902-110,
saxs@embl-hamburg.de (SAXS)
beam@embl-hamburg.de (PX).

Access to the EMBL Hamburg facilities will be supported by the European
Commission, Research Infrastructure Action under the FP7 "ELISA (European
Light Sources Activities)".
[Added 10 december 2009]


November 2009

Beam time is available at the NSLS

Please visit the website at www.px.nsls.bnl.gov and select "Get Access to Beam Time." The PXRR (Macromolecular Crystallography Research Resource at the NSLS) operates five beamlines for macromolecular crystallography (MX).

Two of these beamlines are undulators: X29 is the most efficient MX machine east of Chicago in the US, often serving three different research groups in a day. X25 is as bright, and has counted Rod MacKinnon, Tom Steitz, and Venki Ramakrishnan among its prize-winning users. Typical beam sizes at these undulators are 50 microns. If your crystal is only 20 microns, we can give you a beam that size.

There are ALS-style automounters at X29 and two of our dipole beamlines, X12-B and X12-C.

We have a new station at X26-C for the coordinated measurement of optical absorption spectroscopic and x-ray diffraction data. Several publications have come from this work and many projects are underway. A Raman spectrometer is being installed now.

The PXRR is funded jointly by the NIH's National Center for Research Resources and the DOE's Office of Biological and Environmental Research.
[Added 3 November 2009]


September 2009

CALL FOR PROPOSALS FOR BEAMTIME WITH ONLINE MICROSPEC

Proposal Deadline 26th September 2009

There will be beamtime available at the ESRF for MX data collection with a setup that allows online monitoring of UV/VIS spectral changes of the crystal during the X-ray diffraction experiment. Users who are interested in using this beam time (including those who are members of BAG Groups) should use the following mechanism:

http://www.esrf.fr/UsersAndScience/UserGuide/Applying/ProposalGuidelines/MXnon-BAGproposal

and it must be clearly indicated in the title of the proposal form that the online monitoring of spectral changes is necessary for the project.

A brief description of the device is given below however users are encouraged to consult the web pages for detailed information:

http://www.esrf.fr/UsersAndScience/Experiments/MX/How_to_use_our_beamlines/Run_Your_Experiment/Microspectrophotometer_User_Guide

As this is not a standard setup, it might take a significant amount of time to train users, align the device, and analyse the data in order to derive relevant data collection schemes. We will therefore schedule 24 hours for each project. The deadline for this specific application is Saturday 26th September 2009
[Added 14 September 2009]


August 2009

MX beamtime at CLS Dear Crystallographers,
At the Canadian Light Source the Call for Proposals is currently open AND accepting General User Proposals.

* Macromolecular Crystallography (08ID-1 beamline)

http://www.lightsource.ca/uso/macromolecular_crystallography.php

Please visit http://ex.lightsource.ca/cmcf/ to gain updated information about our experimental setup.

Regards,
Pawel
__________________________
Pawel Grochulski, Ph.D., D.Sc.
Canadian Macromolecular Crystallography Facility
Canadian Light Source Inc.,
101 Perimeter Road, Saskatoon,
SK S7N 0X4, Canada.
http://ex.lightsource.ca/cmcf/
[Added 20 August 2009]


Call for MX-beamtime at HZB-BESSY-II, Berlin, period: January/2010 - December/2010, Deadline: September 1. 2009

Next MX-proposal application deadline: September 1, 2009
See: http://www.bessy.de/boat/www/

We kindly request new MX-proposals for beamtime applications for the next beamtime period.
In order to apply for beamtime, please register at the BESSY on-line access tool "BOAT" (http://www.bessy.de/boat/www/) and submit a new beamtime application proposal. It is possible to propose a number of projects within the proposal lifetime of one year. HZB-BESSY provides beamtime at the MX-beamlines 14.1 and 14.2. The requested beamtime is granted based on the reviewed proposal and reports from previous research activities at BESSY. Results from previous projects stated in the "Experimental Reports" will affect the chances for future beamtimes significantly. Please make sure to include them if available.

New experimental setup:
We are offering the hard- and software environment for carrying out
UVRIP experiments at BL14.1. For further information, please visit:
http://www.helmholtz-berlin.de/forschung/funkma/soft-matter/bessy-mx/beamlines/bl14-1/hardware/uvrip_en.html

The upgraded experimental station at BL14.1. has the following key features:
- Photonflux: 2x10¹¹ Phot/sx100mAx0.05%BW at sample position (0.11-20 sec exposure time per frame)
- MX-225 X-ray detector, 720mm max. distance from the sample, 30 deg max. 2Theta
- Microdiffractometer (MD2) with Mini-kappa goniometer MK3 - Automatic sample changer (CATS), 90 sample storage capacity (SPINE-Pin & EMBL sample magazine compatibility)
- 96-well crystallization plate scanning (test phase)
- New high performance data processing environment
- EDNA, STAC installed and availalbe
- Bruker AXS X-Flash XRF detector on BL14.1+2
-MX-225 X-ray detector at BL14.2
Please visit our web page www.helmholtz-berlin.de/bessy-mx to gain updated
information about our experimental setup and other requirements.

Uwe Mueller & the HZB BESSY-MX group
[Added 20 August 2009]


July 2009

APPLICATION PROCEDURE FOR PROPOSALS FOR BEAMTIME ON THE ESRF Bio-SAXS BEAMLINE ID14-3
----------------------------------------------------------------------------------------

REMINDER: APPLICATION PROCEDURE FOR PROPOSALS FOR BEAMTIME ON THE ESRF Bio-SAXS BEAMLINE ID14-3

The new Bio-SAXS beamline at ID14-3 at the ESRF ( http://www.esrf.fr/UsersAndScience/Experiments/MX/About_our_beamlines/ID14-3 ) was officially inaugurated on the 15th June 2009 (http://www.esrf.fr/news/general/inauguration_ID14-3/inauguration_ID14-3/). Robotic sample loading is now available on the beam-line using a device constructed in a collaboration between the EMBL (Grenoble and Hamburg outstations) and the ESRF. Automated data analysis will also be implemented following the model of the SAXS facility at X-33, EMBL Hamburg.

Eventually the end-station will be fully automated (sample loading, data collection, processing and preliminary analysis) and will rapidly provide users standard data concerning the size (radius of gyration, maximum dimension and volume) and molecular weight of samples and allow on-the fly /ab-inito/ shape reconstruction in order to provide feedback enabling the data collection strategies to be optimized. Future plans extend to allowing remote access to the new Bio-SAXS facility, based on the system currently in use on the ESRF's MX end-stations.

Application for beam-time on this facility can be made via the rolling access mechanism at ANY time. Those who wish to apply (including members of ESRF MX BAG Groups) should use the mechanism at:
http://www.esrf.fr/UsersAndScience/UserGuide/Applying/ProposalGuidelines/MXnon-BAGproposal
where it must be clearly indicated in the title of the proposal that the application is for Bio-SAXS beamtime on ID14-3.
[Added 29 July 2009]


June 2009

SLS PX Beamlines: Call for Proposals is Open - Deadline June 15, 2009

Dear SLS users, Call is open for proposals for the PX (Protein Crystallography) beamlines of the Swiss Light Source, SLS. Deadline for proposal submission: Monday, June 15, 2009. Submission: All submissions will be handled by the SLS Digital Users Office (DUO) /contact: slsuo@psi.ch Please consult the following website to obtain information about the status of the different beamlines and the procedure to set-up the proposal: http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls/PX/index .html In case of questions related to the experiments at the PX beamlines, please contact one of the beamline scientists: http://sls.web.psi.ch/view.php/beamlines/px/staff/index.html With kind regards Stefan Müller on behalf of the SLS team


[Added 22 June 2009]


Beamtime available at CHESS, September 16-November 10, 2009

The CHESS/MacCHESS facility, located at Cornell University in Ithaca, NY, invites macromolecular crystallographers and users of BioSAXS to apply for time on one or more of our stations:

A1 station, monochromatic wiggler source, suitable for Se SAD experiments as well as native data collection, with ADSC Q-210 detector.

F1 station, monochromatic wiggler source, suitable for Br SAD or native data, with ADSC Q-270 detector and ALS-type automounter.

F2 station, wiggler source tunable from 7 - 14 keV, suitable for MAD/SAD experiments, with ADSC Q-210 detector. Also can be equipped for BioSAXS experiments.

F3 station, bending magnet source with multilayer optics, tunable from 5.9 - 15.4 keV, suitable for SAD experiments using Fe, Co, etc., with ADSC Q-4u detector.

G1 station, wiggler source with multilayer optics, general purpose station one of whose standard configurations is for SAXS experiments; good data can be obtained for d-spacings up to 2500 Angstroms.

===== Special options ======

Pressure-cryocooling of (unfrozen) crystals is available by prearrangement. This method can reduce the damage induced by cryocooling, often with no need for cryoprotectants (Kim et al., Acta Cryst. D61, 881-890 (2005)).

Microbeam (down to about 5 microns) using focusing capillary optics is available on request at any of the stations.

======= Support =======

CHESS/MacCHESS provides a high level of support for all users. We are very willing to help with non-standard experimental setups - just ask. Our staff scientists also invite collaborations for more extended projects investigating novel techniques.

Mail-in service is available - we will be pleased to collect (and process, if you like) data from crystals that you send to us.

======== Applying for time ========

Visit http://www.chess.cornell.edu and look at "Beam Time" under the "Users" menu. All applications can be done on line, any time. Processing of proposals is rapid, with a turn-around time of just a couple of weeks for the usual Express Mode option.

More information is available on the web site, or contact administrator Kathy Dedrick, kd73@cornell.edu.


[Added 22 June 2009]


May 2009

ESRF Rolling access beamtime

The ESRF is pleased to remind you about the procedure for applying for rolling access beamtime on its MX beamlines.
The rolling access procedure is designed to improve access to ESRF MX beam-lines and encourage the use of ESRF facilities by smaller groups working in the MX field. This method of applying for beam-time can be used by scientists who are NOT included in a ESRF blocked group (BAG) and applications can be made at ANY time. Applications received under this new scheme will be reviewed electronically by the ESRF MX Beam Time Review Committee within 7-14 days of their reception at the ESRF and if beam-time is awarded this will be scheduled within 6-8 weeks after the time of application. The ESRF is currently accepting applications for rolling access beamtime required in June and July 2009.

Further details of the scheme as well as details of application procedures are available at:
http://www.esrf.fr/UsersAndScience/UserGuide/Applying/MXApplications/#standard

Any questions regarding this new application mechanism should be initially directed to Debby Davison (deborah.davison@esrf.fr), or the the MX Beamline Operation Managers (David Flot (david.flot@esrf.fr) and Didier Nurizzo (nurizzo@esrf.fr).
[Added 29 May 2009]


April 2009

Beam Time at LS-CAT Sector-21 at APS
I would like to take the time to welcome all general users to the newest beam lines at the Advance Photon Source, Life Sciences CAT Sector 21.

http://ls-cat.org http://protein.nsls.bnl.gov/

There is time available for rapid access, the dates are listed on the website and users can subscribe for upcoming times too.

LS-CAT current;y operates three ID end stations, one station (21ID-D) is fully tunable with an MD2, MX-300 and CATS robotic sample changer. 21ID-F & G are fixed wavelength at 0.978A with MX-225 and MX-300 detectors, both stations have MD2s and CATS robots too.

To schedule time visit the LS-CAT website.

If you like to know more send an email:

k-brister@ls-cat.org

or call:

+1 (630) 252 0626

Joseph S Brunzelle, PhD
Assistant Research Professor
Dept. Mol Pharm & Bio Chem
Life Sciences Collaborative Access Team
Synchrotron Research Center, Northwestern University
Ph. 630-252-0629 Fax. 630-252-4664
j-brunzelle@northwestern.edu
http://www.ls-cat.org

[Added 1 Apr 2009]


March 2009

Beam time available @X6A NSLS

http://protein.nsls.bnl.gov

The NIGMS beam line X6A at the National Synchrotron Light Source has recently replaced its end-station. The beam line now operates a ADSC Q270 CCD detector and a Crystallogic diffractometer equipped with an air-bearing single rotation axis. For screening large numbers of sample an ALS like automounted sample changer capable of screen 16 samples in 40 minutes is available upon request.

Beam time can be scheduled as fast as making reservations for a trip. Just locate the available beam time on the schedule and use the drop down menu to select the date that fits best into your schedule. Of course you need to have a project first, but this is easy too.. just submit a small abstract (http://protein.nsls.bnl.gov) and your project will be reviewed within a few days.

If you like to know more

send an email:

x6ansls@bnl.gov
[Added 24 Mar 2009]


CALL FOR ESRF SYNCHROTRON BEAM TIME WITH ONLINE DEHUMIDIFIER AT BEAMLINE ID14-2

********************************************************
CALL FOR ESRF SYNCHROTRON BEAM TIME WITH ONLINE
DEHUMIDIFIER AT BEAMLINE ID14-2
********************************************************

Proposal Submission Deadline: 31st March 2009

Beamtime will be available from the 14th to the 17th May 2009 at the ESRF for MX data collection (beamline ID14-2) with a device that allows precise control of the humidity of the crystal prior to X-ray diffraction experiments. The device (EMBL HC1b) provides a room temperature humid airflow with adjustable relative humidity [50- 99 %]. Many crystals have been shown to improve their diffraction properties upon dehydration. The machine control software is connected to the host beamline to run dehydration protocols while taking X-ray diffraction images automatically. Users are encouraged to consult the web pages for detailed information

(http://www.esrf.eu/UsersAndScience/Experiments/MX/About_our_beamlines/ID14-2/HC1b).
[Added 24 Mar 2009]


MAX-lab beamtime Deadline March 20th 2009

CALL FOR PROPOSALS for beam time at MAX-lab, Lund, Sweden.

Researchers using synchrotron radiation are invited to submit proposals for beam time for experiments to be carried out during the time period July 2009 to June 2010.

The available facilities include beamlines for MX and SAXS, see below.

Information on how to prepare and submit proposals as well as descriptions of the other experimental facilities available at MAX-lab can be found at http://www.maxlab.lu.se

It is also possible to apply for Fast Access MX beam time at any time though it is recommended to submit normal proposals if possible.

*** The proposal deadline is March 20th, 2009 ***

[Added 16 Mar 2009]


February 2009

MX-beamtime at BESSY-Berlin, period: July/2009 - June/2010,

Next MX-proposal application deadline: March 1, 2009

See:
http://www.bessy.de/boat/www/

We kindly request new MX-proposals for beamtime applications for the next beamtime period.

In order to apply for beamtime, please register at the BESSY on-line access tool "BOAT" (http://www.bessy.de/boat/www/) and submit a new beamtime application proposal. It is possible to propose a number of projects within the proposal lifetime of one year. BESSY provides beamtime at the MX-beamlines 14.1 and 14.2. The requested beamtime is granted based on the reviewed proposal and reports from previous research activities at BESSY. Results from previous projects stated in the "Experimental Reports" will affect the chances for future beamtimes significantly. Please make sure to include them if available.

New experimental setup:
We are offering the hard- and software environment for carrying out UVRIP experiments at BL14.2. For further information, please visit: http://www.mx.bessy.de/userguide/beamlines/bl1/uvrip.shtml

The upgraded experimental station at BL14.1. has the following key features:
- Photonflux: 2x10 Phot/sx100mAx0.05%BW at sample position (1-20 sec exposure time per frame)
- MX-225 X-ray detector, 720mm max. distance from the sample, 30 deg max. 2Theta
- Microdiffractometer (MD2) with Mini-kappa goniometer MK3
- Automatic sample changer (CATS), 90 sample storage capacity (SPINE-Pin & EMBL sample magazine compatibility)
- 96-well crystallization plate scanning (test phase)
- New high performance data processing environment - Bruker AXS X-Flash XRF detector on BL14.1+2
-MX-225 X-ray detector at BL14.2

Please visit our web page (http://www.mx.bessy.de) to gain updated information about our experimental setup and other requirements.

Uwe Mueller & the BESSY-MX group

[Added 16 Feb 2009]


PROTEIN CRYSTALLOGRAPHY STATION AT LANSCE -- CALL FOR PROPOSALS
====================================================================
for Run Cycle Beginning the June 2009

You are invited to apply for beam time on the neutron Protein Crystallography Station (PCS) at the Los Alamos Neutron Science Center. The deadline for submitting proposals is 6:00 p.m. (1800) Mountain Standard Time on Sunday, March 2, 2009. Any proposals submitted after the due date will not be reviewed by the Program Advisory Committees and must be resubmitted for the following run cycle. Rapid access proposals may be submitted at any time, but require compelling evidence of sufficient scientific urgency to justify special scheduling.

The PCS is a high performance neutron protein crystallography beam line funded by the Office of Biological and Environmental Research of the U.S. Department of Energy. Users of the PCS have access to free neutron beam-time, free perdeuration services and also support for data reduction and structure analysis.

For more technical information about the PCS and experimental requirements, contact Paul Langan (505) 665 8125, langan_paul@lanl.gov

Proposal Guidance and Submission
Proposals must be submitted using the process on the LANSCE website. Only proposals submitted in this manner will be accepted.
-To access the proposal submission site, go to the LANSCE home page, http://lansce.lanl.gov/ .
-From there, click on the Lujan tab then select “Submit a proposal for beam time”.
-Step-by-step instructions can be found on the Proposal Home web page.

Should you have any questions or require assistance, please contact the LANSCE User Office by e-mail at lansce_users@lanl.gov or by telephone at (505) 665-1010.

[Added 16 Feb 2009]


Beam time available @ the NIGMS beam line at the NSLS

http://protein.nsls.bnl.gov

The NIGMS beam line X6A at the National Synchrotron Light Source provides FAST access to beam time through out the year. To apply submit a short proposal to http://protein.nsls.bnl.gov at any time. Proposals are continuously reviewed and beam time can be scheduled within a week.

For comments or further questions please contact the scientific staff at:
x6ansls@bnl.gov
or call:
+1 (631) 344 8375

[Added 16 Feb 2009]


January 2009

BEAM TIME AVAILABLE FOR MACROMOLECULAR CRYSTALOGRAPHY

BEAM TIME AVAILABLE FOR MACROMOLECULAR CRYSTALLOGRAPHY AT THE TWO ID BEAMLINES OF NE-CAT AT APS.

Beamline 24ID-C: Variable energy between 6-18keV, ADSC Q315 Detector, MAD Capable.

Beamline 24ID-E: Equipped with MD2 microdiffractometer, delivering beam as
small as 5 microns. Single energy (12662eV), ADSC Q315 Detector.

Contact csalbego@anl.gov for further details.

See http://necat.chem.cornell.edu for information on our beamlines and a calendar of available days.
[Added 26 Jan 2009]


CALL for PROPOSAL on ESRF BIO-SAXS BEAMLINE ID14-3 User operation on the new Bio-SAXS beamline at ID14-3 at the ESRF
(http://www.esrf.fr/UsersAndScience/Experiments/MX/About_our_beamlines/copy_of_ID14-3) began in November 2008 with mounting of samples
currently performed manually. Robotic sample loading will be incorporated on the beam-line in the coming months using a device being constructed
in a collaboration between the EMBL (Grenoble and Hamburg outstations) and the ESRF. Automated data analysis will be also implemented following
the model of the SAXS facility at X-33, EMBL Hamburg.

Eventually the end-station will be fully automated (sample loading, data collection, processing and preliminary analysis) and will rapidly provide
users standard data concerning the size (radius of gyration, maximum dimension and volume) and molecular weight of samples and allow on-the
fly ab-initio shape reconstruction in order to provide feedback enabling the data collection strategies to be optimized. Future plans extend to
allowing remote access to the new Bio-SAXS facility, based on the system currently in use on the ESRF's MX end-stations.

Application for beam-time on the new facility will follow a rapid access model and can be made at ANY time. Those who which to apply
(including members of ESRF MX BAG Groups) should use the mechanism at:
http://www.esrf.fr/UsersAndScience/UserGuide/Applying/ProposalGuidelines/MXnon-BAGproposal

where it must be clearly indicated in the title of the proposal that the application is for Bio-SAXS beamtime on ID14-3.
[Added 26 Jan 2009]


CALL FOR PROPOSALS FOR ESRF BEAMTIME WITH ONLINE MICROSPEC

Proposal Deadline 31st January 2009

There will be beamtime available at the ESRF for MX data collection with
a setup that allows online monitoring of UV/VIS spectral changes of the
crystal during the X-ray diffraction experiment. Users who are
interested in using this beam time (including those who are members of
BAG Groups) should use the following mechanism:

http://www.esrf.fr/UsersAndScience/UserGuide/Applying/ProposalGuidelines/MXnon-BAGproposal

and it must be clearly indicated in the title of the proposal form that
the online monitoring of spectral changes is necessary for the project.

A brief description of the device is given below however users are
encouraged to consult the web pages for detailed information:

http://www.esrf.fr/UsersAndScience/Experiments/MX/How_to_use_our_beamlines/Run_Your_Experiment/Microspectrophotometer_User_Guide

As this is not a standard setup, it might take a significant amount of
time to train users, align the device, and analyse the data in order to
derive relevant data collection schemes. We will therefore schedule 24
hours for each project. The deadline for this specific application is
Saturday 31st January 2009

++++++++++++
*Dates of beam-time: 20th - 23rd February 2009
*Storage Ring: 7/8 +1 (200mA)
Beamline: ID14-2
Energy: 13.29 keV

Specifications:
UV/VIS-range: 250-800nm
ODmax: 2-2.5
min integration time: 50ms
Light source: OceanOptics DH2000, Halogen/D2-lamp
Monitoring Light size: 0.03 (min) - 0.15mm(max)
Sampling freq (to disk): 10Hz or lower

[Added 20 Jan 2009]


SLS PX Beamlines: Call for Proposals is Open

Call is open for proposals for the PX (Protein Crystallography) beamlines of the Swiss Light Source, SLS.

Deadline for proposal submission: Sunday, February 15, 2009.
Submission: All submissions will be handled by the SLS Digital Users Office (DUO) /contact: slsuo@psi.ch

Please consult the following website to obtain information about the status of the different beamlines and the procedure to set-up the proposal:
http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls/PX/index.html

In case of questions related to the experiments at the PX beamlines, please contact one of the beamline scientists: http://sls.web.psi.ch/view.php/beamlines/px/staff/index.html
[Added 19 Jan 2009]


December 2008

Applications for synchrotron beam time 2009 at EMBL Hamburg

Call for access to Synchrotron Beamline Facilities 2009

EMBL Hamburg, Germany

We announce a call for synchrotron beam time applications in biological
small-angle scattering (SAXS) and X-ray crystallography (PX). Up to 32
weeks of beam time will be available at the DORIS storage ring (DESY)
from March 2009 to February 2010.

EMBL Hamburg will operate the following beamlines:

Beamline New features Scientist responsible
X33 SAXS Automated and remote operation Dmitri Svergun
X11 PX MAR555 Flat Panel detector Paul Tucker
X12 PX MAD, S-SAD, fluorescence analysis Manfred Weiss
X13 PX Microspec, expert data collection Matthew Groves
BW7A* PX High flux, multilayer optics Andrea Schmidt
BW7B* PX Automated sample changer MARVIN Santosh Panjikar
*These beamlines are used as Petra-III test facilities and therefore will
be only temporarily available.

The deadline for submission of proposals is January 13, 2009.
An external Priorities Committee will assess the proposals.

Electronic beam proposal forms and a detailed description of the beamline
facilities are available at www.embl-hamburg.de and
www.embl-hamburg.de/facilities

Access to the EMBL Hamburg high-throughput crystallisation facility is
available via www.embl-hamburg.de/services/crystallisation

EMBL is constructing three new beamlines for applications in biological
X-ray crystallography (PX) and small-angle scattering (SAXS) at the Petra-III
synchrotron storage ring, which are scheduled to be available from 2010/11.
See www.embl-hamburg.de/services/petra for further information.

For further information
tel. +49-40-89902-110,
saxs@embl-hamburg.de (SAXS)
beam@embl-hamburg.de (PX).

Access to the EMBL Hamburg facilities will be supported by the European
Commission, Research Infrastructure Action under the FP7 "ELISA (European
Light Sources Activities)".


[Added 22 Dec 2008]


Deadline for beamtime proposals at BM14 -ESRF for 2009 -submit your proposals now!

Dear all, deadline for submission of proposals for beamtime at BM14 for beamtime at ESRF for the first run of 2009 is this Friday, the19th decemeber 2008 -get in your proposals now before the christmas break!. Beamline proposals can be submitted on-line from the BM14 webpages at
http://www.bm14.ac.uk

PLEASE remember this call is distinct from ESRF proposal call and allows you direct access to BM14 -special requests can be forwarded directly to me and we will do our best to accommodate you.
[Added 18 Dec 2008]


November 2008

Call for applications to the Membrane Protein Lab at Diamond

Applications are now invited for proposals to use the Membrane Protein Laboratory (MPL) at the Diamond Light Source Ltd.

Closing date for applications: 4th December, 2008.

MPL website: http://www.diamond.ac.uk/Science/MPL

The MPL is a user facility open to anyone who is studying membrane proteins.
If you are interested in learning more about crystallising and solving structures of membrane proteins or large complexes, please read on.

The MPL is located in the Diamond Synchrotron in Oxfordshire, England. It is a collaboration between Prof. So Iwata at Imperial College and
Dame Prof. Louise Johnson and Dr Gwyndaf Evans at Diamond. It is a fully equipped laboratory forexpression, purification and crystallisation
of membrane proteins. Applications can be made to the MPL for regular visits or for a period of up to 3 months to work within the MPL.
Applications are reviewed by our scientific advisory boardand visits can be arranged when applications have been accepted.

What does the MPL offer to users:

In addition to the MPL crystallisation facility we can also offer assistance with expression and purification of membrane proteins through collaboration with Dr David Drew,
who has developed many useful techniques for expression and purification of membrane proteins in E. coli and yeast systems (Drew et al., Protein Science, 14, 2011-2017,
2005; Drew et al.,Nature Methods, 3, 303-313, 2006; Newstead et al., PNAS, 104, 13936-13941,2007; Drew et al., Nature Protocols, 3, 784-798, 2008).

Membrane proteins can be difficult to solve due to the data being of low resolution and anisotropic. Dr Alex Cameron, who has experience in solving structures using such data,
eg the hydantoin transporter (Science, Vol. 322,pp. 709 – 71, 2008), can provide assistance and training to MPL users.

Time will be allocated from January onwards once the review process is completed.
[Added 18 Nov 2008]


User proposal submission for Collaborative Crystallography at BCSB

Dear Users,

Through the Collaborative Crystallography Pilot Program (CC) at the Advanced Light Source, scientists can send protein crystals to
Berkeley Center for Structural biology (BCSB) staff researchers for data collection and analysis. The CC Pilot Program can provide
a number of benefits to researchers:


Thumbnail Description:
======================
The Collaborative Crystallography program will be piloted on beamlines 5.0.1 and 5.0.2 for one year; if successful it will be implemented on a permanent basis.
CC proposals will go through the regular ALS General User proposal review process for beamtime allocation. Proposals will be reviewed and ranked by the Proposal
Study Panel, and beamtime will be allocated accordingly. BCSB staff will schedule the projects to fit into the available resources. Only non-proprietary projects will
be accepted. As a condition of participation, BCSB staff researchers who participate in data collection and/or analysis must be appropriately acknowledged - typically
being included as authors on publications and in PDB depositions. Please consult the website for additional information at:

http://bcsb.als.lbl.gov/wiki/index.php/Collaborative_Crystallography

=============
How To Apply:

To submit a proposal, go to:
http://www-als.lbl.gov/als/quickguide/independinvest.html

Click on "protein crystallography" to begin proposal. For question 3 select "Collaborative PX 501/502." For question 9, please describe a specific research project with
a clear end point. In order to request CC time for January/February 2009 allocation period, proposals must be submitted by November 15, 2008.

The deadline for CC proposals for the time period March/April 2009 will be January 15, 2009.

Regards,
Banumathi Sankaran
[Added 11 Nov 2008]


October 2008

Correlated optical spectroscopy and x-ray diffraction at beamline X26-C

Time is available for correlated optical spectroscopy and x-ray diffraction at beamline X26-C of the National Synchrotron Light Source at Brookhaven National Laboratory. This dedicated capability is available full time and can be accessed by on-site visits, or via our Mail-In program. We offer rapid and flexible beamtime scheduling through our web site:

http://www.px.nsls.bnl.gov/

The incident light is currently delivered from a Newport 75W Xe arc lamp (~350-850nm) through fiber optical cables and a microscope objective to probe a ~25 micron region of the cryo-cooled crystal. The optical spectra are typically collected before, during and after x-ray exposure, in less than one second with an Ocean Optics USB 4000 CCD-based spectrophotometer. The data can be collected and analyzed with the SpectraSuit software package in a LINUX environment.

You may also contact me directly for more information.


Allen M. Orville, Ph.D.
Biology Department
Brookhaven National Laboratory
Upton, NY 11973-5000

e-mail: amorv@bnl.gov
phone 631-344-4739
fax 631-344-2741
www.biology.bnl.gov/structure/orville.html
[Added 14 Oct 2008]


=================================================================
SYNCHROTRON BEAM TIME FOR MACROMOLECULAR CRYSTALLOGRAPHY
AT THE UNDULATOR BEAMLINE X06SA AT SLS FROM JANUARY TO APRIL 2008
=================================================================

PILATUS 6M pixel detector available for user operation at High Resolution Diffractometer. Continuous, fine phi-sliced data acquisition (12.5 frames per second) with 20 bit dynamic range,
see http://pilatus.web.psi.ch/ or www.dectris.com for further information

mar225 CCD installed at Micro-Diffractometer MD2. This MAD-compatible diffractometer allows for data collection with a focussed beam size of 25 x 5 micrometers, and down to 10 x 5 micrometer using an apertures.

SPINE compatible CATS sample changer installed at HRD-diffractometer.

ACTOR sample changer operational at the Micro-Diffractometer.

SLS is able to provide support for travel and accomodation for two users per trip: http://sls.web.psi.ch/view.php/users/experiments/eusupport/index.html

For recent highlights: http://sls.web.psi.ch/view.php/beamlines/px/research/index.html

PROPOSAL SUBMISSION DEADLINE: Wednesday, October 15th 2008.

For further information and / or proposal submission: http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls/PX/index.html
[Added 5 Oct 2008]


September 2008

Call for proposals: SLS PX beamlines

Call is open for proposals for the PX (Protein Crystallography) beamlines of the Swiss Light Source, SLS.
Deadline for porposal submission: Wednesday, October 15, 2008
Submission: All submissions will be handled by the SLS Digital Users Office (DUO) /contact: slsuo@psi.ch

Please consult the following website to obtain information about the status of the different beamlines and the procedure to set-up the proposal:
http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls/PX/index.html

In case of questions related to the experiments at the PX beamlines, please contact one of the beamline scientists:
http://sls.web.psi.ch/view.php/beamlines/px/staff/index.html
[Added 30 Sept 2008]


Deadline for applications for beamtime at BM14 -RUN oct-DEC 2008

The deadline for submission of proposals for beamtime at BM14 for beamtime at ESRF during Nov/Dec 2008 is next Friday 3rd october 2008 -get in your proposals now!. Beamline proposals can be submitted on-line from the BM14 webpages at http://www.bm14.ac.uk

PLEASE remember this call is distinct from ESRF proposal call and allows you direct access to BM14 -special requests can be forwarded directly to me and we will do our best to accommodate you.
[Added 28 Sept 2008]


Call for Proposals for Diamond

Call for proposals for the fifth allocation period AP5 (April 2009 – September 2009) is now open. This is for direct access mode only.

Direct access is aimed at providing access for beamtime in a 6 month period. This call is applicable to all operational beamlines I02, I03, I04, I06, I11, I15, B16, I16, I18, I19, I22, B23 & I24. Please note the 4 beamlines which came online in October 2008 (I11, I19, B23 & I24) will be operating with reduced beamtime. Please refer to the beamline web area for further information on the beamlines and we recommend that you discuss your experiment with the Principal Beamline Scientists before submitting your proposal. Applications should be made via the online proposal system which is available on the home page of the User Office on the external site.

Users should look at the guidelines and instructions in the Information tab before starting; they have been updated to give details on the alternative method of inputting sample data via an excel file (this is recommended for users with more than 3 samples) and the minor modification to the online software. Proposals which have previously been submitted will be available and can be used as a template for a new proposal simply by using the copy button.

Please note, if you are using an old proposal as a template for a new proposal then please go through all sections of the online system before you resubmit.

The deadline for this call is before midnight on Wednesday 1st October 2008.

The Diamond Peer Review Panel will assess proposals for this period on scientific merit and will advise Diamond Management accordingly. Users will be informed of the decision on proposals in January 2009.

If you have any problems with the software or have any other questions then please contact the User Office on useroffice@diamond.ac.uk or +44 (0) 1235 778571.

Web: www.diamond.ac.uk
[Added 16 Sept 2008]


BEAM TIME AVAILABLE FOR MACROMOLECULAR CRYSTALLOGRAPHY AT THE TWO ID BEAMLINES OF NE-CAT AT APS.

Beamline 24ID-C: Variable energy between 6-18keV, ADSC Q315 Detector, MAD Capable.

Beamline 24ID-E: Equipped with MD2 microdiffractometer, delivering beam as small as 5 microns. Single energy (12662eV), ADSC Q315 Detector.

Contact csalbego@anl.gov for further details.

See http://necat.chem.cornell.edu for information on our beamlines and a calendar of available days.
[Added 15 Sept 2008]


Version 1.21 of the Crystallography and NMR System (CNS)

==================================================================

Announcing version 1.21 (general release) of the software:

Crystallography & NMR System (CNS)
(copyright 1997-2008, Yale University)

==================================================================

Information about the software and instructions for downloading the most recent version are available at:
**************************************************
************ http://cns-online.org ********************
**************************************************

The software is available for download, free-of-charge, by all academic (non-profit) users.

------------------------------------------------------------------
Installation instructions and documentation can be found in:
$CNS_SOLVE/doc/html/cns_solve.html
once you have downloaded and installed the software.
------------------------------------------------------------------
[Added 1 Sept 2008]


June 2008

Call for proposals: Australian Synchrotron.

We are now accepting general user proposals for Run 3 2008 (September – December) for beamline 3-BM1

The deadline for submission of proposals is July 1st 2008

The details on how to submit are outlined below:

Information of submission of proposals
http://www.synchrotron.org.au/content.asp?Document_ID=5386

Online proposal system: http://prism.nbi.ansto.gov.au/as/proposal/index.jsp
[Added 19 June 2008]



=================================================================
SYNCHROTRON BEAM TIME FOR MACROMOLECULAR CRYSTALLOGRAPHY
AT THE UNDULATOR BEAMLINE X06SA AT SLS FROM SEPTEMBER- DEC 2008
=================================================================

- PILATUS 6M pixel detector available for user operation at High Resolution Diffractometer.
Continuous data acquisition (12.5 frames per second) with 20 bit dynamic range, see
http://pilatus.web.psi.ch/ or www.dectris.com as well as
http://www.nature.com/nature/journal/v452/n7185/full/nature06717.html
for further information

- CATS sample changer available at the High Resolution Diffractometer, cf.
http://www.irelec.fr/en/produit.asp?idproduit=38

- Detector upgrade to mar225 CCD on Micro-Diffractometer MD2. This MAD-compatible
diffractometer allows for data collection with a beam size of 15 x 5 micrometers. ACTOR
sample changer available at the MD2.

- SLS is able to provide support for travel and accomodation for two users per trip:
http://sls.web.psi.ch/view.php/users/experiments/eusupport/index.html

- For recent highlights: http://sls.web.psi.ch/view.php/beamlines/px/research/index.html

PROPOSAL SUBMISSION DEADLINE: Sunday, June 15th 2008.

For further information and / or proposal submission:
http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls/PX/index.html


Looking forward to seeing you at SLS,

Clemens Schulze-Briese

[Added 10 June 2008]


BEAM TIME AVAILABLE FOR MACROMOLECULAR CRYSTALLOGRAPHY AT THE TWO ID BEAMLINES OF NE-CAT AT APS.

Beamline 24ID-C: Variable energy between 6-18keV, ADSC Q315 Detector, MAD Capable.

Beamline 24ID-E: Equipped with MD2 microdiffractometer, delivering beam as small as 5 microns. Single energy (12662eV), ADSC Q315 Detector.

Contact csalbego@anl.gov for further details.

See http://necat.chem.cornell.edu for information on our beamlines and a calendar of available days.
[Added 4 June 2008]


May 2008

Call for proposals: SLS PX beamlines
====================================
Call is open for proposals for the following
crystallography beamlines of the Swiss Light
Source, SLS:

PXI (X06SA)
PXII (X10SA)
PXIII (X06DA)

Periods:
=======
September 1, 2008 - December 31, 2008 (normal, test)
September 1, 2008 - August 31, 2010 (long term)

Deadline:
========
for submission is Sunday, June 15, 2008.

Submission:
===========
All submissions will be handled by the SLS Digital Users
Office DUO (https://duo.psi.ch/).

oooooooooooooooooooooooooooooooooooooooooooooooooooooooooo
Notes (please read):
======
a) beamline PXII is reserved for MPG users. Other academic
users are therefore asked to submit proposals for PXI
or PXIII.

b) beamline PXIII is a beamline based on a superbending
magnet
(http://sls.web.psi.ch/view.php/beamlines/px3/index.html)
Proposers interested in technical details are asked to
contact the beamline manager (Meitian Wang,
meitian.wang@psi.ch).

b) For the proposal evaluation by the Proposal Review
Committee, DUO Experimental Reports on previous
experiments represent a very important input, and
a missing experimental report may seriously affect
the chances of acceptance. Proposers are asked to
supply a separate experimental report for each
experiment performed. Note that now also a co-proposer
can input an experimental report.

c) The SLS is part of the EU I3 initiative and we will
be able to provide travel and accommodation support.
Proposers interested in this support are asked to mark
the corresponding box in the proposal. For further
details please go to:
http://sls.web.psi.ch/view.php/users/experiments/eusupport


Info:
====
For further information about proposal and / or experimental
report submission please go to
http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls

For further information about the SLS beamlines please go to
report submission, please go to
http://sls.web.psi.ch/view.php/beamlines


Help:
====
In case of questions, please contact the Users' Office at

slsuo@psi.ch


For the SLS Team
Stefan Mueller and Heinz J. Weyer
[Added 12 May 2008]


Synchrotron beam time at EMBL Hamburg

This is a gentle reminder of our call for beam time applications at EMBL Hamburg that we circulated a few weeks ago. We kindly ask you to complete your beam time proposal by the deadline of ---> 16 May 2008 <----

If you have already taken action, please ignore this message.
[Added 1 May 2008]


April 2008

Aminoff Symposium, June 11-12 2008
The Royal Swedish Academy of Sciences has decided to award the Gregori Aminoff Prize for 2008 to Professor Hans Eklund, Swedish University of Agricultural Sciences, Biomedical Center, Uppsala "for his structural studies of ribonucleotide reductase".
The prize will be presented at the Academy on June 11, 2008.

A two-day symposium will be organized, June 11-12, in honour of the laureate.
The symposium will illuminate the latest developments and results in the field of structural biology.

For more information about the prize and registration to the symposium; visit www.kva.se.
Please register before 30 May 2008.
[Added 15 April 2008]


Announcing pdb-l FAQ and PDBWiki

We have created an unofficial FAQ page and Wiki for this list. In the FAQ we have summarized answers to some of the most frequently asked questions from the list archives.

The FAQ page is part of a website called PDBWiki. PDBWiki contains one wikipedia-style page per PDB entry where details about each structure can be discussed.

The site can serve as a bugtracker, discussion forum and community annotation system for PDB structures.

FAQ page: http://pdbwiki.org/index.php/PDB_FAQ

Wiki: http://pdbwiki.org

In order to avoid spam, you may have to solve a captcha before editing pages. Comments and suggestions are welcome.

Henning Stehr (Dipl. Ing.)
Bioinformatics/Structural Proteomics Group
Max-Planck-Institute for Molecular Genetics
Ihnestrasse 63-73
14195 Berlin, Germany

rapid access @ X6A, NSLS

Got crystals? would like to screen them.....

Beamtime available @ X6A for rapid access

http://protein.nsls.bnl.gov

The NIGMS beam line X6A at the National Synchrotron Light Source provides FAST access to beamtime throughout the year. The beam line is also equipped with an automated sample changer that allows to screen crystals rapidly and efficiently.

If you like to take advantage please contact the beam line staff at:
x6ansls@bnl.gov
or call:
+1 (631) 344 8375
[Added 10 April 2008]


Call for access to Synchrotron Beamline Facilities 2008

We announce a call for synchrotron beam time applications in biological X-ray crystallography (PX) and small-angle scattering (SAXS). Up to 12 weeks of beam time will be available at the DORIS storage ring (DESY) during the period September 2008 until December 2008. The EMBL Outstation will operate the following beamlines:


Beamline Type Wavelength Scientist responsible
X11 PX 0.8 Å Paul Tucker
X12 PX tuneable Manfred Weiss
X13 PX 0.8 Å Matthew Groves
X33 SAXS 1.5 Å Dmitri Svergun, Manfred Roessle

The deadline for submission of proposals is May 16th, 2008. An external Priorities Committee will assess the proposals.

Electronic beam proposal forms and detailed description of the beamline facilities are available via the web links http://www.embl-hamburg.de and http://www.embl-hamburg.de/services.

In parallel, EMBL-Hamburg is constructing three new beamlines for applications in biological X-ray crystallography (PX) and small-angle scattering (SAXS) at the Petra-III synchrotron storage ring, with an expected opening in 2010/11. Further information can be obtained under http://www.embl-hamburg.de/services/petra.

Two of the DORIS-III beamlines (BW7A, BW7B) will be used as test beamlines for future Petra-III applications. Depending on circumstances, they may become temporarily available to the external user community.

Applications to use the EMBL-Hamburg high-throughput crystallisation facility can be made at any time at http://www.embl-hamburg.de/services/crystallisation.

Further information can be obtained by tel. +49-40-89902-110, (fax +49-40-89902-149), Email beam@embl-hamburg.de (PX), svergun@embl-hamburg.de (SAXS).

Access to the EMBL Hamburg facilities is supported by the European Commission, Research Infrastructure Action under the FP6 'Structuring the European Research Area Specific Programme', Contract Number RII3-CT-2004-506008.
[Added 3 April 2008]


March 2008

X6A @ NSLS: Beam time available

The NIGMS beam line X6A at the National Synchrotron Light Source provides FAST access to beam time through out the year. To apply submit a short proposal to http://protein.nsls.bnl.gov at any time. Proposals are continuously reviewed and beam time can be scheduled within a week.

For comments or further questions please contact the scientific staff at: x6ansls@bnl.gov
[Added 25 March 2008]


Announcing the 12th Annual SBNet conference, June 13 - 16, 2008

Dear SBNetter!

We are pleased to announce the Twelfth Annual SBNet Conference to be held at åkerblads Hotel in beautiful Tälllberg.

Registration for the 12th Annual SBNet Conference will open at 13.00 pm on Monday March 31 2008.

The registration homepage will be available at http://www.strubio.org.umu.se/SBNet08/.

Registration will close at 10.00 am on April 11 2008 (or when the meeting is fully booked - whichever comes first). Invoices (on a group basis) will be sent out before the end of April. Invoices must be paid on time, otherwise the registration is forfeited. If the conference has not been fully booked it will be possible to register also after April 11, however at a "full coverage" fee.

Conference Fees:
Student special fee: 2 300 kr (poster required, double room)
Academic double room: 3 400 kr
Academic single room: 4 200 kr
Industry/other double room: 3 900 kr + VAT
Industry/other single room: 4 700 kr + VAT

After April 11:
Double room: 5200 kr + VAT
Single room: 5900 kr + VAT

The conference is limited to 180 participants. Up to 80 students or post-docs (only those who are employed by a Swedish academic institute; and only for those who received or will receive their PhD after January 1, 2002) who present a poster will be able to attend the meeting at reduced cost. Since these places will be allocated on a first come, first served basis, applicants are advised to prepare a poster abstract ****now** so that they can register immediately when the registration process begins!

The poster abstracts will be available on the internet from mid April.

Transportation (bus) will be available from Gothenburg and Stockholm/Uppsala, and travel grants will be awarded to academic participants from other Swedish Universities (e.g. Lund, Linköping and Umeå).

As last year, the main sessions will be held in the mornings and afternoons and the poster sessions on Saturday and Sunday.
For those of you who have attended any of the previous SBNet meetings, this format will be familiar. The traditional football match between the rivaling X-ray/EM and the NMR/Modeler teams will be held as usual on Saturday afternoon!

Preliminary scientific programme:

Saturday morning, 14/6:
Method development (and applications) in NMR, X-ray and EM
Chairs: Salam Al-Karadaghi and Göran Karlsson
Keynote speaker 1: Randy Read, Univ. of Cambridge (confirmed)
Keynote speaker 2: tba.

Saturday afternoon:
Protein folding, dynamics and predictions
Chair: Michael Akke
Keynote speaker: tba.

Sunday morning, 15/6:
Hot Picks
Chair: Maria Selmer
Keynote lecturer: Patrick Cramer, Ludwig-Maximilians-University München, (confirmed)

Sunday afternoon
Membrane proteins
Chair: Arjan Snijder
Keynote speaker: tba.

Sunday evening Session:
chair: Anders Liljas
Keynote speaker: Elena Conti, MPI of Biochemistry Martinsried (confirmed)

Monday moring, 16/6:
Protein Structure and Disease
Chair: Hasse Eklund
Keynote lecturer: David Eisenberg UCLA (confirmed)

We are looking forward to seeing you all in Tällberg !

Elisabeth Sauer-Eriksson, Uwe Sauer, Magnus Wolf-Watz, Jürgen Schleucher
[Added 19 March 2008]


Collaborative Crystallography

The Berkeley Center for Structural Biology (BCSB) is pleased to announce a new Collaborative Crystallography Pilot Program (CC) at the Advanced Light Source in Berkeley. Through this program, scientists are able to send protein crystals to BCSB staff researchers for data collection and analysis.

The CC Pilot Program provides a number of benefits to researchers:

CC proposals go through the regular ALS General User proposal review process. They are reviewed and ranked by the Proposal Study Panel, and beamtime is allocated accordingly. BCSB staff schedule the projects to fit into the available resources. Please note that only non-proprietary projects are currently being accepted. In keeping with similar programs the BCSB staff researchers who participate in data collection and/or analysis should be appropriately acknowledged as authors on publications and/or PDB depositions.

Please consult the website for additional information at:
http://bcsb.als.lbl.gov/wiki/index.php/Collaborative_Crystallography

How To Apply:

To submit a proposal, go to:
http://alsusweb.lbl.gov/4DCGI/WEB_GetForm/PXProposalEntry.shtml

For question 3 select "Collaborative PX 501/502." For question 9, please describe a specific research project with a clear end point. In order to request CC time for May/June, 2008, proposals must be submitted by March 15, 2007.

Questions:
For comments or questions, feel free to contact Banumathi Sankaran (BSankaran@lbl.gov) or Gari Kloss (MKloss@lbl.gov)
[Added 14 March 2008]


MacCHESS on F2 station available

We still have openings available for the MAD station F2 during the month of April.
There have been a number of recent improvements to F2, so if you haven't used the station in a while, you might want to check it out. Microbeam optics are available for this line on request. Interested users should contact Kathy Dedrick kd73@cornell.edu.
[Added 14 March 2008]


New service from IUCr Journals

You may be interested to hear of a new service we have just launched for IUCr Journals that allows authors to create enhanced interactive illustrations of structures to include in their articles. The first illustration prepared in this way appears in the article of Mueller-Dieckmann et al. [Acta Cryst. (2008), F64, 156-162] on the crystal structure of mouse ADP-ribosylhydrolase 3. The illustration is a view rendered within an interactive Jmol applet so readers may change the orientation and size of the view and, by right-clicking within the illustration, they have access to the full repertoire of menu options provided by Jmol. The toolkit used to create this illustration is now available and forms an integral part of the IUCr submission and review systems. It can be accessed from the Acta D or Acta F author services pages (http://journals.iucr.org/).

More details have been published in an editorial [Acta Cryst. (2008), F64, 154-155] and any comments or feedback on the service are very welcome.

Louise Jones
Technical Editor
Acta Crystallographica Sections D & F
IUCr
5 Abbey Square
Chester CH1 2HU
England
[Added 10 March 2008]


Beamtime Available for Macrocrystalography at the two ID beamlines of NE-CAT at APS

Beamline 24ID-C: Variable energy between 6-18keV, ADSC Q315 Detector, MAD Capable.

Beamline 24ID-E: Equipped with MD2 microdiffractometer, delivering beam as small as 5 microns. Single energy (12662eV), ADSC Q315 Detector.

Contact csalbego@anl.gov for further details.
See http://necat.chem.cornell.edu
[Added 10 March 2008]


2008 Rigaku Post-doc Summer Travel Bursary Awards

Rigaku Americas Corporation is pleased to announce the availability of five (5) awards of $500 each to post-doctoral research fellows to help with the costs of travel to upcoming summer meetings such as the ACA meeting in Knoxville, TN (May 31 - June 5), the IUCr meeting in Osaka (August 23-31) and/or another upcoming meeting.

One can apply for the award through a simple web form on the Rigaku web site: http://www.rigaku.com/protein/postdoc.html
[Added 7 March 2008]


CALL FOR PROPOSALS for beam time at MAX-lab, Lund, Sweden.

Researchers using synchrotron radiation are invited to submit proposals for beam time for experiments to be carried out during the time period July 2008 to June 2009.

The available facilities include beamlines for MX and SAXS, see below.

Information on how to prepare and submit proposals as well as descriptions of the other experimental facilities available at MAX-lab can be found at http://www.maxlab.lu.se

It is also possible to apply for Fast Access MX beam time at any time though it is recommended to submit normal proposals if possible.

*** The proposal deadline is March 14th, 2008 ***
_______________________________________________________________________
MACROMOLECULAR CRYSTALLOGRAPHY

Beam time for macromolecular crystallography is available at:

All beamlines are equipped with user-friendly data collection software.
For more information, see the beamline web site: http://www.maxlab.lu.se/beamlines/bli911


_______________________________________________________________________
SAXS

Beam time is also available at the SAXS station at beamline I711. This recently developed low background set-up offers the possibility to measure in a q range down to 0.007 Å-1 depending on the chosen sample to detector distance. The set-up is further described at: http://www.maxlab.lu.se/beamlines/bli711
_______________________________________________________________________
ACCESSIBILITY AND SUPPORT

MAX-lab is situated in Lund, 50 km or 30 minutes by car from Copenhagen airport (with less than 2 hour flights from e.g. London, Paris, Strasbourg, Munich, Budapest, Helsinki,...). Trains leave the airport every 20 to 40 minutes (44 minutes to Lund). Users from EU countries and associated states can apply for financial support through the project "Integrating Activity on Synchrotron and Free Electron Laser Science (IA-SFS)" within the Sixth Framework Programme (more information can be found in the beam time application instructions).
_______________________________________________________________________

[Added 7 March 2008]


February 2008

MAX I, II and II: Call for proposals

It is now time to submit proposals for projects to be carried out at MAX I, MAX II and MAX III during the time period July 2008 to June 2009.

The proposal deadline is March 14, 2008

Proposals must be submitted as electronic documents using our submission service on the web server. Information on how to prepare and submit proposals as well as descriptions of the experimental facilities at MAX I, MAX II and MAX III are available on our web-site http://www.maxlab.lu.se

NOTE: Those of you who received a two year block allocation for PX last year do not need to apply this year.
[Added 21 February 2008]


Call for Proposals for Beamtime with Online Microspec

Proposal Deadline *1st March 2008

*There will be beamtime available at the ESRF for MX data collection with a setup that allows online monitoring of UV/VIS spectral changes of the crystal during the X-ray diffraction experiment. Users who are interested in using this beam time (including those who are members of BAG Groups) should using the following mechanism:

http://www.esrf.fr/UsersAndScience/UserGuide/Applying/ProposalGuidelines/MXnon-BAGproposal

and it must be clearly indicated in the title of the proposal form that the online monitoring of spectral changes is necessary for the project.

A brief description of the device is given below however users are encouraged to consult the web pages for detailed information:

http://www.esrf.fr/UsersAndScience/Experiments/MX/How_to_use_our_beamlines/Run_Your_Experiment/Microspectrophotometer_User_Guide Application deadline: 20 March 2008
[Added 18 February 2008]


Call for beamtime proposals

Deadline for submission of proposals for beamtime at bm14 is set for next Wednesday (20th Feb 2008) Proposals arriving on this date will be considered for scheduling in the April/May 2008 synchrotron run at the ESRF. Beamline proposals can be submitted on-line from the BM14 webpages (Click on Apply for Beamtime from the MainMenu Frame on the homepages at http://www.bm14.ac.uk).

PLEASE remember this call is distinct from ESRF proposal call and allows you direct access to BM14 –special requests can be forwarded directly to me and we will do our “avis” to accommodate you.

Full details of the beamline characteristics, the user program and the procedure for the submission of electronic proposals can be found at the beamline homepage http://www.bm14.ac.uk or by following the links from http://ww.embl-grenoble.fr or http://www.esrf.eu

Application deadline: 20 March 2008
[Added 18 February 2008]


BEAMTIME AT SLS X06SA and X06DA

=================================================================
SYNCHROTRON BEAM TIME FOR MACROMOLECULAR CRYSTALLOGRAPHY
AT THE UNDULATOR BEAMLINE X06SA AND THE SUPERBENDING MAGNET BEAMLINE X06DA AT SLS FROM MAY - AUGUST 2008
=================================================================

- PILATUS 6M pixel detector available for user operation at High Resolution Diffractometer.
Continuous data acquisition (10 frames per second) with 20 bit dynamic range,
see http://pilatus.web.psi.ch/ or www.dectris.com for further information

- Detector upgrade to mar225 CCD on Micro-Diffractometer MD2. This MAD-compatible
diffractometer allows for data collection with a beam size of 5 micrometers.

- NEW : the superbend beamline X06DA. Mini-hutch design for efficient sample mounting.
CATS sample changer in preparation. For further information:
http://sls.web.psi.ch/view.php/beamlines/px3/index.html

- SLS is able to provide support for travel and accomodation for two users per trip:
http://sls.web.psi.ch/view.php/users/experiments/eusupport/index.html

- For recent highlights: http://sls.web.psi.ch/view.php/beamlines/px/research/index.html

PROPOSAL SUBMISSION DEADLINE: Friday, Feb 15th 2008 (midnight)

For further information and / or proposal submission:
http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls/PX/index.html
[Added 18 February 2008]


Practical Protein Crystallization Course
September 15-19, 2008
Uppsala University, Uppsala, Sweden

Website: http://xray.bmc.uu.se/~terese/course/course.htm

How to apply
Application is by e-mail only to terese.bergfors@icm.uu.se. Explain your connection to structural biology i.e., give your group affiliation, your PhD advisor's name, or your scientific project. Then state in maximum 200 words why you need a course in crystallization at this particular stage of your research career. Do not send attachments. Be sure to include your full address, telephone and fax numbers in the e-mail. If you have applied previously to this course and not gotten in, please mention this in your application. Preference will be given to people who are re-applying.

Application deadline: 20 March 2008
[Added 18 February 2008]


Two crystallographic wikis: call for your contribution
CCP4 user community wiki: http://strucbio.biologie.uni-konstanz.de/ccp4wiki/index.php/Main_Page

This wiki was planned by Tassos and me, and Artem and Clemens joined us lately. Unfortunately this has almost no contents so far, but we hope that people who post answers on the CCP4 mailing list will take the time and compose/edit the corresponding articles of the wiki. The intention is that the wiki will capture the breadth of topics on CCP4BB, which will make it a useful resource e.g. for "frequently asked questions", offloading some of the question/answer traffic on CCP4BB to a more permanent mode of storage.

XDSwiki: http://strucbio.biologie.uni-konstanz.de/xdswiki/index.php/XDS

for XDS users. This has quite a bit of information already. The purpose of this wiki is to provide an accurate resource for XDS users, and to provide explanations and hints for the successful use of XDS. It has Tips and Tricks for XDS usage, explanations of its output, and recommendations for the parameters in XDS.INP (if it appears useful to deviate from their defaults).
[Added 18 February 2008]


Call for proposals to visit the Membrane Protein Laboratory (MPL) at the Diamond Light Source, Oxfordshire.

The MPL is a facility for purification, crystallisation and structural studies of membrane proteins. It is located at the Diamond Light Source and is a collaborations with Imperial College London.
The Director is Prof. So Iwata. The MPL is funded by the Wellcome Trust.

This facility is open to applications from groups anywhere in the world.

If you are interested in working at the MPL, please follow this link to read more:
http://www.diamond.ac.uk/MPL/default.htm

If you would like to apply, please download the forms from this page and return them to Liz Carpenter by the 27th of February.
http://www.diamond.ac.uk/MPL/MPLUser.htm
[Added 18 February 2008]


The EMBO Young Investigator Programme has been identifying and supporting outstanding life scientists in Europe since 2000. The programme targets researchers who are within four years of having established their first independent laboratories in an EMBC member state. The aim of the programme is to give these promising young scientists an added advantage in the early years of their independent careers, drawing attention to the quality of their research and enhancing their standing in the scientific community. Website: http://www.embo.org/yip/
Deadline for application: 1 April, 2008
[Added 1 February 2008]


Neutron Protein Crystallography Call for Proposals
for Run Cycle Beginning the Week of June 5 2008

You are invited to apply for beam time on the neutron Protein Crystallography Station (PCS) at the Los Alamos Neutron Science Center. The deadline for submitting proposals is 6:00 p.m. (1800) Mountain Standard Time on Sunday, March 3rd, 2008. Successful proposals will be scheduled during the period June 5, 2008 through mid-December 2008. Please note that there will only be one proposal cycle in calendar year 2008. Because of the long duration of this run cycle, fast access proposals will be accepted throughout, but require compelling evidence of sufficient scientific urgency to justify scheduling.

The PCS is a high performance neutron protein crystallography beam line funded by the Office of Biological and Environmental Research of the U.S. Department of Energy. Users of the PCS have access to free neutron beam-time, free perdeuration services and also support for data reduction and structure analysis (http://mnc.lanl.gov).

For more technical information about the PCS and experimental requirements, contact Paul Langan (505) 665 8125, langan_paul@lanl.gov

PROPOSAL GUIDANCE AND SUBMISSION
Proposals must be submitted using the process on the LANSCE website; only proposals submitted in this manner will be accepted. To access the proposal submission sites, log onto the LANSCE home page (http://lansce.lanl.gov). On this page you will find the link "Submit a Proposal." Click on this link and submit your PCS proposal at the site for the Lujan Neutron Scattering Center.
Detailed instructions for preparing the proposals can be found on the proposal submission sites under "Step-by-Step Guide to Submitting an Online Proposal."
[Added 1 February 2008]


Call for MX-beamtime proposals for BESSY-Berlin

Period: July/2008 - June/2009
Next MX-proposal application deadline: February 15th 2008

See:
http://www.bessy.de/boat/www/

We kindly request MX-proposals for beamtime applications for the next beamtime period.

In order to apply for beamtime, please register at the BESSY on-line access tool "BOAT" (http://www.bessy.de/boat/www/) and submit a new beamtime application proposal. It is possible to propose a number of projects within the proposal lifetime of one year. BESSY provides beamtime at the MX-beamlines 14.1 and 14.2. The requested beamtime is granted based on the reviewed proposal and reports from previous research activities at BESSY.

New experimental setup:>br> We are offering the hard- and software environment for carrying out UVRIP experiments at BL14.1. For further information, please visit: http://www.psf.bessy.de/userguide/beamlines/bl1/uvrip.shtml

Starting from Summer 2008, the completely upgraded experimental station at BL14.1 will be available to the users.
Key features are:

  • Photonflux: 2xE11 Phot/sx100mAx0.05%BW at sample position (1-20 sec exposure time per frame)
  • Marmosaic 225mm X-ray detector (already available) , 700mm max. distance towards the sample, 30 deg max. 2Theta
  • Microdiffractometer (MD2) with Mini-kappa goniometer
  • Automatic sample changer (CATS), 90 sample storage capacity (SPINE-Pin & EMBL sample magazine compatibility)
  • 96-well crystallization plate scanning
  • New high performance data processing environment (already available)
  • Marmosaic 225mm X-ray detector at BL14.2 (May 2008)

    Please visit our web page (http://www.psf.bessy.de) to gain updated information about our experimental setup and other requirements.
    [Added 1 February 2008]


    January 2008

    Application of beam time at ESRF

    The ESRF is pleased to remind you about the procedure for applying for rolling access beamtime on its MX beamlines.
    The rolling access procedure is designed to improve access to ESRF MX beam-lines and encourage the use of ESRF facilities by smaller groups working in the MX field. This method of applying for beam-time can be used by scientists who are NOT included in a ESRF blocked group (BAG) and applications can be made at ANY time. Applications received under this new scheme will be reviewed electronically by the ESRF MX Beam Time Review Committee within 7-14 days of their reception at the ESRF and if beam-time is awarded this will be scheduled within 6-8 weeks after the time of application. The ESRF is currently accepting applications for rolling access beamtime required in January and February 2008.

    Further details of the scheme as well as details of application procedures are available at:
    http://www.esrf.fr/UsersAndScience/UserGuide/Applying/MXApplications/#standard

    Any questions regarding this new application mechanism should be initially directed to Debby Davison (deborah.davison@esrf.fr), or the the MX Beamline Operation Managers (Joanne McCarthy (mccarthy@esrf.fr) and Didier Nurizzo (nurizzo@esrf.fr).
    [Added 20 January 2008]


    nCNS - neutron diffraction patch for CNSsolve 1.1 has been released.

    Software *nCNS* version 1.0.0 has just been released. *nCNS* is a patch for CNSsolve V1.1 , combining for the first time, global X-ray crystallography, neutron crystallography and energy refinement with cross-validated maximum likelihood refinement. *nCNS* can therefore be used in an interoperable way for X-ray, neutron or joint X-ray/neutron analyses of biological macromolecules.

    Download from: http://mnc.lanl.gov/

    *nCNS* is produced by the "Computational Tools for Macromolecular Neutron Crystallography" (MNC) consortium between Los Alamos National Laboratory http://www.lanl.gov and Lawrence Berkeley National Laboratory http://www.lbl.gov. Neutron capabilities have also been added to PHENIX http://www.phenix-online.org.

    *nCNS* is distributed under the terms of the GNU General Public License as published by the Free Software Foundation ; either version 2 of the License, or (at your option) any later version. The development of neutron computational tools for *nCNS* and *phenix.refine* is funded by NIH-NIGMS grant (1R01GM071939).
    [Added 20 January 2008]


    Call for proposals: SLS PX beamlines

    Call is open for proposals for the following
    crystallography beamlines of the Swiss Light
    Source, SLS:

    PXI (X06SA)
    PXII (X10SA)
    PXIII (X06DA)

    Periods:
    May 1, 2008 - August 31, 2008 (normal, test)
    May 1, 2008 - April 30, 2010 (long term)

    Deadline for submission is Friday, February 15, 2008.

    All submissions will be handled by the SLS Digital Users
    Office DUO (https://duo.psi.ch/).


    Notes (please read):
    a) beamline PXII is reserved for MPG users. Other academic users are therefore asked to submit proposals for PXI or PXIII.

    b) beamline PXIII is a new beamline based on a superbending magnet (http://sls.web.psi.ch/view.php/beamlines/px3/index.html) Proposers interested in technical details are asked to contact the beamline manager (Meitian Wang, meitian.wang@psi.ch).

    c) For the proposal evaluation by the Proposal Review Committee, DUO Experimental Reports on previous experiments represent a very important input, and a missing experimental report may seriously affect the chances of acceptance. Proposers are asked to supply a separate experimental report for each experiment performed. Note that now also a co-proposer can input an experimental report.

    d) The SLS is part of the EU I3 initiative and we will be able to provide travel and accommodation support. Proposers interested in this support are asked to mark the corresponding box in the proposal. For further details please go to: http://sls.web.psi.ch/view.php/users/experiments/eusupport

    Info:
    For further information about proposal and / or experimental report submission please go to http://sls.web.psi.ch/view.php/users/experiments/proposals/opencalls
    For further information about the SLS beamlines please go to report submission, please go to http://sls.web.psi.ch/view.php/beamlines

    Help: in case of questions, please contact the Users' Office at slsuo@psi.ch
    [Added 15 January 2008]


    Call for targets: the CAPRI experiment:

    A Critical Assessment of PRedicted Interactions http://capri.ebi.ac.uk

    The community-wide CAPRI experiment is a blind test of the ability of protein docking algorithms to predict the mode of association of two proteins based on their three- dimensional structure. A CAPRI Round starts whenever an experimentalist offers an adequate target, and ends four to eight weeks later with the submission of predicted structures. A CAPRI target is a new, unpublished X-ray or NMR structure of a protein- protein complex, the components of which have a known 3D structure.

    CAPRI has been running for six years, during which 30 targets have been subjected to blind predictions. Special issues of Proteins dated July 1, 2003, Aug. 1, 2005 and Dec. 2007 describe the results. The experiment has greatly helped the 60-odd groups that participate in developing new methods and algorithms. Its continuation depends on experimentalist offering new targets.

    We call upon crystallographers who just completed, or hope to complete soon, the structure of a protein-protein complex, to make it available for prediction. If both components of the complex are already known, the predictors will be given the two PDB entry codes. If only one component structure is known, the other can be taken from the complex and communicated on a confidential basis. Four to eight weeks later, a complete set of coordinates should be forwarded to the CAPRI assessors. They will remain confidential until released by their authors.

    The CAPRI Management Group: Kim Henrick (EBI Hinxton, UK), Joël Janin (Orsay, France), Lynn Ten Eyck (San Diego, CA), Michael Sternberg (London, UK), Sandor Vajda (Boston, MA), Ilya Vakser (Lawrence, KA), Shoshana Wodak (assessor, Toronto, Canada) To submit a target to CAPRI, just contact Joël Janin at joel.janin@u-psud.fr
    [Added 10 January 2008]


    Old news ...


    SBNet Latest update at 5 March, 2010.