Research

The colours in the tables below indicate roughly the status of the projects, varying from red (meaning we spend a lot of time and effort on it), via orange (slightly less, but still high on the list), yellow and green to blue (dormant or largely finished). Future projects are shown on a white background.

RED
ORANGE
YELLOW
GREEN
BLUE
WHITE


Protein Crystallographic Projects

Structural studies of semicarbazide-sensitive amine oxidase (SSAO) (2001-present)
Structural studies of eukaryotic initiation factor 5A (eIF5A) (2000-present)
Structural studies of KRAB-motif-containing proteins (2000-present)
Structural studies of glutathione S-transferases (GSTs) (2000-present)
Structural studies of EgFABP1 and 2 (2000-present) [PDB: 1O8V]
Structural studies of Cel45A (1999-present)


Structural Bioinformatics Projects

Left-handed helices in protein structures (2002-present)
Structure and fold comparison methods
Indonesia: a modular Java workbench for structure-based sequence alignment and analysis
Structural motif recognition
Various aspects of (protein) structure analysis


Protein Crystallographic Methods Development Projects

Register errors in protein structures (2002-present)
Uppsala Electron-Density Server (EDS) [with Prof TA Jones (Uppsala)] [web-site]
Model quality and validation [review]
Tools for density interpretation [with Prof TA Jones (Uppsala)]
Jiffies [X-UTIL package]
Density averaging [RAVE package]
Non-crystallographic symmetry [LSQMAN program]
Refinement and rebuilding practice [(p)reprint]


Miscellaneous & Old Projects

Structural studies of rat mast-cell protease-2 (RMCP-2) (2000-2001)
Structural studies of Inhibitor of Apoptosis Proteins (IAPs) (1997-2001)
Structural studies of monoamine oxidase (MAO) (1997-2001)
Cel6A [PDB: 1CB2 1HGY]
ACBP [PDB: 1HB6 1HB8]
Homology modelling of expansin
Homology modelling of caspase-8 [with A Rufini (Roma)]
Endoglucanase I [PDB: 1EG1]
Lysozyme (X-ray methodology) [PDB: 2CDS]
Chloromuconate cycloisomerase (X-ray methodology) [PDB: 2CHR]
Complex between acetylcholinesterase and the snake venom toxin fasciculin II [PDB: 1FSS]
Complex between immunoglobulin Fc (Igg1) and the C2 fragment of protein G [PDB: 1FCC]
Alpha2u-globulin [PDB: 2A2U 2A2G]
Cellular retinoic-acid-binding proteins I and II [PDB: 1CBS 1CBQ 1CBR 2CBR 2CBS 3CBS]
Glutathione S-transferase (A1-1) [PDB: 1GUH]



Latest update at 28 February, 2003.