My interests

I write easy to use multiresolution modeling software which helps predict how large biological molecules form and move.  I and my collaborators have applied it to lots of problems, such as group I and group II intron structure, ribosome hybridization, and telomerase elongation.  I’m also working on antibody design and other viral applications.

Currently I’m extending my software, MMB, to handle huge complexes even more efficiently.  A new feature called “physics where you want it” will let you apply a physics-based force field to a restricted region of your complex, e.g. an active site or interface, while treating the rest with coarser forces and kinematics.  MMB will also start reading electron densities and other experimental data, expanding the types of constraints that can be used for modeling.  

Cell and Molecular Biology

Uppsala University