Molecular Biology
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Anton Zavialov's Home@Work PageMy research is primarily focused on understanding mechanisms of action of molecular chaperones, proteins that assist the non-covalent folding/unfolding and the assembly/disassembly of other macromolecular structures. The mechanisms are revealed by determining conformational and energetic changes both in chaperones and substrate proteins during the chaperone assisted folding and assembly. In addition, I perform more “traditional” structure-function studies of a family of surface organelles of Gram negative pathogens (e.g. Yersinia and Salmonella spp), which we call “polyadhesins assembled via the FGL chaperone-usher pathway”, a novel family of extracellular signaling proteins, the adenosine deaminase related growth factors (ADGF), and a family of cystein proteases, the metacaspases, which are involved in the programmed cell death in plants. Funding Our studies are supported by grants from the Swedish Research Council (Natural Science and Medicine) and the Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning (FORMAS). Group members Xiaodi Yu (Dee), PhD student Mubinur Rahman (Mubin), PhD student Saumendra Prasad Roy, Researcher Former group members Srisailam Marupakula , now at SLU, Uppsala, Sweden Ganesh Ram, now at GBB, Haren, The Netherlands Jinghui Luo, now at SU, Stockholm, Sweden Are you interested in doing a PhD, postdoc or undergraduate project / examensarbete with me? You are most welcome to contact me! Courses Methods in Protein ChemistryPublicationsNews:Our "Structural basis for the growth factor activity of human adenosine deaminase ADA2" is choosen as Paper of the Week! Our new huge review on fimbrial adhesins is published! The Nature paper is out!
Contact information Anton Zavialov Assoc. Professor (Docent) Department of Molecular Biology Swedish University of Agricultural Sciences Uppsala Biomedical Centre P.O. Box 590 S-751 24 Uppsala Sweden Email: Anton.Zavialov@molbio.slu.se |
 The Caf1M-Caf1 chaperone-subunit complex 
The Caf1M-Caf1-Caf1 chaperone-subunit-subunit complex
Free Caf1M chaperone forms tetramers
The plug domain of the Caf1A usher Human adenosine deaminase growth factor ADA2 |
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Molecular Biology Box 590, SE-751 24 Uppsala (visiting address: Husargatan 3, Biomedical Center entrance C11) • Updated Janiary 8, 2008. Anton Zavialov |
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