Bke2 Biochemistry Lectures

Lecture 15: Mechanisms of enzyme regulation
Reading material: Horton, Chapters 5.10, 10.12, 11, 14.3 & 14.7 (Stryer, Chapter 10, parts of 13, 19, 20, 23)

Abstract: Metabolic pathways are regulated in several ways. Some enzymes like pepsin and the pancreatic serine proteases which cleave proteins in the food are synthesized as inactive precursors which are activated by proteolysis. Many key enzymes in metabolism are allosterically regulated, often through feed-back inhibition. Phosphorylation of enzymes is a general way to regulate their activity.

Key concepts:
Branchpoint enzymes
Committed step
Feedback inhibition
Regulatory mechanisms:
Allostery, cooperativity
Activation/inhibition
Reversible covalent modification
Proteolytic activation
Cascades
Glycogen synthesis and breakdown
Phosphorylase
Control of glycolysis
Hexokinase
Phosphofructokinase
Pyruvate kinase
Induced fit

Lecture index

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