Bke2 Biochemistry Lectures

Lecture 20: Metabolism of amino acids
Reading material: Horton chapter 18

Abstract: Most bacteria and plants synthesise all of their amino acids. Mammals on the other hand can only synthesise about half of the twenty common amino acids. The rest of amino acids must be obtained via the diet. The catabolism of the amino acids includes removal of the ammonium group, usually by transamination with a-ketoglutarate. Ammonium is converted to urea in the urea cycle. The carbon chains in amino acids can be converted to several different intermediary metabolites used in catabolic and anabolic reactions.

Key concepts:
Tansamination
Urea cycle
Glutamate
a-ketoglutarate
Pyridoxyl phosphate
Glucogenic
Ketogenic

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